公开(公告)号：US11951272B2

公开(公告)日：2024-04-09

申请号：US17443523

申请日：2021-07-27

Applicant: City University of Hong Kong

Inventor： Chenjie Xu ,  Hao Chang

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61M2202/03 ,  A61M2202/07 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2202/30 ,  A61M2210/0612

Abstract: A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.

公开(公告)号：US11696818B2

公开(公告)日：2023-07-11

申请号：US16461404

申请日：2017-11-16

Applicant: SyrinJector Ltd.

Inventor： Nahum Cohen

IPC: A61D1/02 ,  A61D7/00 ,  A61M5/145 ,  A61M5/158 ,  A61M5/168 ,  A61M5/172 ,  A61M5/42 ,  A61M5/44 ,  A61M5/46

CPC classification number: A61D1/025 ,  A61D7/00 ,  A61M5/14546 ,  A61M5/158 ,  A61M5/16886 ,  A61M5/172 ,  A61M5/425 ,  A61M5/44 ,  A61M5/46 ,  A61M2005/14506 ,  A61M2202/30 ,  A61M2205/13 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2205/6054 ,  A61M2205/8206 ,  A61M2209/06 ,  A61M2250/00

Abstract: A system for mass vaccination includes a plurality of portable electronic injectors, a mobile process manager and a database. Each portable electronic injector includes at least one needle to administer a measured amount of at least one vaccine to a body skin/tissue and an indicator system to provide an indication when either an injection error occurs or when a vaccination indication is required. The mobile process manager is in wireless communication with the plurality of injection devices and controls a mass vaccination. The process manager transmits task data to all injection devices in parallel via WI-FI, receives the vaccination indications from each injector in real time, also receives injection errors and vaccination process data, alerts a vaccination process overseer generally in real-time of the errors and transmits the injection data from each injector via cellular and/or internet transmission to the database.

公开(公告)号：US11642506B1

公开(公告)日：2023-05-09

申请号：US17572838

申请日：2022-01-11

Applicant: Win Coat Corporation

Inventor： Ta-Jo Liu ,  Wan-Hua Li ,  Han-Yin Cheng ,  Yi-Jyun Liao ,  Wen-Hsu Lien ,  Shin-Yi Yin ,  Ying-Hua Hsu ,  Hsiu-Feng Yeh

IPC: A61M37/00 ,  A61L31/04 ,  B29C41/00 ,  B29C41/22 ,  B29K105/00 ,  B29K29/00 ,  B29L31/00

CPC classification number: A61M37/0015 ,  A61L31/041 ,  B29C41/003 ,  B29C41/22 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2202/30 ,  B29K2029/04 ,  B29K2105/0035 ,  B29L2031/7544

Abstract: Provided is a microneedle patch comprising a substrate part and multiple needle parts protruding from the substrate part. The substrate part consists of a diffusion-proof layer and a base, and each needle part consists of a needle tip, a diffusion-proof layer and a base. The diffusion-proof layer of each needle part is formed between the needle tip and the base of the corresponding needle part. The diffusion-proof layer of the substrate part and the diffusion-proof layer of needle part are one-piece structures, and so are the base of the substrate part and the base of the needle part. The diffusion-proof layer of the microneedle patch can prevent the active ingredients from diffusing to the base, limit the active ingredients to the needle tip and control the carrying quantity thereof.

公开(公告)号：US10071199B2

公开(公告)日：2018-09-11

申请号：US14218409

申请日：2014-03-18

Applicant: InCube Labs, LLC

Inventor： Mir Imran

IPC: A61B17/20 ,  A61K9/00 ,  A61M5/158 ,  A61D1/02 ,  A61D7/00 ,  A61K39/00

CPC classification number: A61M5/158 ,  A61D1/025 ,  A61D7/00 ,  A61K9/0024 ,  A61K39/00 ,  A61M2202/064 ,  A61M2202/30 ,  Y02A50/403 ,  Y02A50/464 ,  Y02A50/48

Abstract: Embodiments of the invention provide multi-stage biodegradable drug delivery platforms and methods for the subcutaneous delivery of therapeutic agents (TA). Embodiments of the platform may be configured to subcutaneously deliver a first dose of a first TA which is absorbed into the body and/or blood stream (BBS) to produce a first therapeutic effect for a first selectable time period (STP), and subsequently after a second STP, deliver a second dose of a second TA which is absorbed into the BBS to produce a second therapeutic effect for a third STP. An embodiment of the platform may comprise a body having a tissue-penetrating end, a primary cavity having a first TA dose and a shell having a secondary cavity having a second TA dose. The first TA dose is released after the first STP and the second TA dose is released after the second STP by biodegradation of the shell.

公开(公告)号：US20180001038A1

公开(公告)日：2018-01-04

申请号：US15703100

申请日：2017-09-13

Applicant: Neogen Corporation

Inventor： James Curtis Biggs, III ,  Arthur Michael Benton, JR. ,  Paul C. Carney

IPC: A61M11/00 ,  B05B12/00 ,  A61M15/08 ,  B05B9/01 ,  B05B15/02 ,  B05B1/34 ,  B05B9/08

CPC classification number: A61M11/006 ,  A61M15/08 ,  A61M2202/30 ,  A61M2207/10 ,  A61M2250/00 ,  B05B1/34 ,  B05B1/3436 ,  B05B9/01 ,  B05B9/0894 ,  B05B12/002 ,  B05B15/50 ,  Y10T29/49433

Abstract: A method of assembling a nozzle assembly is disclosed. The method includes: providing a nozzle member having a central passage defined by at least an inner side surface and an inner distal surface; inserting a fluid atomizer into the central passage of the nozzle member; and, with a distal surface of the fluid atomizer arranged adjacent the inner distal surface of the nozzle member, flexing legs of the fluid atomizer in a radially-outward direction for engaging each leg of the legs with the inner side surface of the nozzle member. A fluid atomizer is also disclosed. A nozzle assembly is also disclosed. A method of utilizing a nozzle assembly is also disclosed.

公开(公告)号：US09687609B2

公开(公告)日：2017-06-27

申请号：US15214915

申请日：2016-07-20

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： Michael Harms

IPC: A61M5/31 ,  A61K38/22 ,  A61K38/26 ,  A61M5/315 ,  A61K9/00 ,  A61K38/28 ,  A61M5/24 ,  A61M39/26 ,  A61M39/22 ,  F16K3/24

CPC classification number: A61M5/31 ,  A61K9/0019 ,  A61K38/2278 ,  A61K38/26 ,  A61K38/28 ,  A61M5/24 ,  A61M5/31505 ,  A61M39/22 ,  A61M39/26 ,  A61M2005/3142 ,  A61M2039/266 ,  A61M2202/07 ,  A61M2202/30 ,  A61M2207/00 ,  F16K3/246 ,  Y10T403/7026

Abstract: A mounting arrangement for a drug-delivery device is proposed, the mounting arrangement comprising: a plug element with a longitudinal axis (L) and a housing part having a recess with a side wall which is adapted to receive the plug element. At least one of the plug element or the side wall of the recess are provided with a protrusion for fixing the plug element in a given position relative to the housing part by a force-fit engagement. Furthermore, a coupling assembly is proposed, the coupling assembly comprising the plug element and the housing part being mechanically coupled to each other.

公开(公告)号：US09687606B2

公开(公告)日：2017-06-27

申请号：US14679321

申请日：2015-04-06

Applicant: Sargon Lazarof

Inventor： Sargon Lazarof

IPC: A61M31/00 ,  A61M5/00 ,  A61M5/31 ,  A61C1/00 ,  A61C5/00 ,  A61M5/178 ,  A61M5/32 ,  A61M5/42 ,  A61N1/36 ,  A61N1/04

CPC classification number: A61M5/3286 ,  A61C5/40 ,  A61M5/178 ,  A61M5/3287 ,  A61M5/422 ,  A61M19/00 ,  A61M2005/3107 ,  A61M2005/3258 ,  A61M2005/3267 ,  A61M2202/048 ,  A61M2202/30 ,  A61M2205/195 ,  A61M2210/0631 ,  A61M2210/0637 ,  A61N1/0456 ,  A61N1/36021

Abstract: Disclosed are applicators and methods for injecting a liquid, such as anesthetic, into a patient with no or minimal pain. The applicator includes a coupling and a blade rotatably mounted on the coupling. The coupling is arranged to receive a cartridge in which a cannula is mounted such that the cannula extends through a proximal channel of the coupling and into a distal channel of the blade. The coupling is further arranged to secure the applicator to a source of liquid such that the liquid can be selectively introduced into and through the cannula into the tissue of the patient. The blade is thin enough for atraumatic insertion into a gingival sulcus of the patient.

公开(公告)号：US20170119872A1

公开(公告)日：2017-05-04

申请号：US15290349

申请日：2016-10-11

Applicant: Seqirus UK Limited

Inventor： Derek O'HAGAN ,  Manmohan SINGH ,  Sung-Yun KWON

IPC: A61K39/145 ,  A61M37/00 ,  A61B17/20 ,  G01N33/68

CPC classification number: A61K39/145 ,  A61B17/205 ,  A61B2017/00004 ,  A61K9/146 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/70 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2202/30 ,  C12N2760/16111 ,  C12N2760/16134 ,  C12N2760/16211 ,  C12N2760/16234 ,  G01N33/68 ,  G01N2333/11

Abstract: Influenza vaccines are administered using solid biodegradable microneedles. The microneedles are fabricated from the influenza vaccine in combination with solid excipient(s) and, after penetrating the skin, they dissolve in situ and release the vaccine to the immune system. The influenza vaccine is (i) a purified influenza virus surface antigen vaccine, rather than a live vaccine or a whole-virus or split inactivated vaccine (ii) an influenza vaccine prepared from viruses grown in cell culture, not eggs, (iii) a monovalent influenza vaccine e.g. for immunising against a pandemic strain, (iv) a bivalent vaccine, (v) a tetravalent or >4-valent vaccine, (vi) a mercury-free vaccine, or (vii) a gelatin-free vaccine.

公开(公告)号：US20170095546A1

公开(公告)日：2017-04-06

申请号：US15332375

申请日：2016-10-24

Applicant: MaxiVAX SA

Inventor： Nicolas Mach

IPC: A61K39/00 ,  A61K9/00 ,  C12P21/00 ,  A61K9/48

CPC classification number: A61K39/0011 ,  A61K9/0019 ,  A61K9/4891 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/515 ,  A61K2039/5152 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/6093 ,  A61M5/178 ,  A61M2202/30 ,  C12N5/0693 ,  C12P21/005 ,  Y02A50/412

Abstract: Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as GM-CSF (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic or preventative vaccination against tumors or infectious agents.

公开(公告)号：US20160325046A1

公开(公告)日：2016-11-10

申请号：US15214915

申请日：2016-07-20

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： Michael Harms

IPC: A61M5/315 ,  A61K9/00 ,  A61K38/22 ,  A61K38/28 ,  A61K38/26

CPC classification number: A61M5/31 ,  A61K9/0019 ,  A61K38/2278 ,  A61K38/26 ,  A61K38/28 ,  A61M5/24 ,  A61M5/31505 ,  A61M39/22 ,  A61M39/26 ,  A61M2005/3142 ,  A61M2039/266 ,  A61M2202/07 ,  A61M2202/30 ,  A61M2207/00 ,  F16K3/246 ,  Y10T403/7026

Abstract: A mounting arrangement for a drug-delivery device is proposed, the mounting arrangement comprising: a plug element with a longitudinal axis (L) and a housing part having a recess with a side wall which is adapted to receive the plug element. At least one of the plug element or the side wall of the recess are provided with a protrusion for fixing the plug element in a given position relative to the housing part by a force-fit engagement. Furthermore, a coupling assembly is proposed, the coupling assembly comprising the plug element and the housing part being mechanically coupled to each other.