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    Novel polygalatenosides and use thereof as an antidepressant agent
    1.
    发明申请
    Novel polygalatenosides and use thereof as an antidepressant agent 有权
    新型多羟基腺苷类及其作为抗抑郁剂的用途

    公开(公告)号：US20080076724A1

    公开(公告)日：2008-03-27

    申请号：US11524470

    申请日：2006-09-21

    Applicant: Mo-Chi Cheng ,  Feng-Nien Ko ,  Tian-Shung Wu

    Inventor： Mo-Chi Cheng ,  Feng-Nien Ko ,  Tian-Shung Wu

    IPC: A61K31/7024 ,  C07H13/02

    CPC classification number: C07H13/02

    Abstract: A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R′ and R″ independently are H or R1, provided that R, R′ and R″ are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.

    Abstract translation: 公开了可用作具有下式的抗抑郁剂的聚天冬氨酸苷：其中R，R'和R“独立地为H或R 1，条件是R，R'和R”不全为H 其中R 1是其中R 2是氢，C 1 -C 6烷基，C 1 -C 6烷氧基或卤素; 或其药学上可接受的盐。 优选地，R 2是H.

    Methods and compositions for inhibiting tumor cell growth
    4.
    发明授权
    Methods and compositions for inhibiting tumor cell growth 失效
    抑制肿瘤细胞生长的方法和组合物

    公开(公告)号：US5340818A

    公开(公告)日：1994-08-23

    申请号：US16052

    申请日：1993-02-10

    Applicant: Ting-Chao Chou ,  Tian-Shung Wu

    Inventor： Ting-Chao Chou ,  Tian-Shung Wu

    IPC: A61K31/435 ,  A61K31/44

    CPC classification number: A61K31/435

    Abstract: The subject invention discloses methods of inhibiting growth of tumor cells which comprise contacting the cells with a growth inhibiting amount of a compound having one of following structures: ##STR1## wherein R.sup.1 is a hydroxyl or acetyl group; R.sup.2 is hydrogen, --CH.sub.2 --CH.dbd.C(CH.sub.3).sub.2 or a method group; R.sup.3 is a hydroxyl, methoxy or acetyl group; R.sup.4 is hydrogen, --CH.sub.2 --CH.dbd.C(CH.sub.3).sub.2 or a methoxy group; R.sup.5 is a hydroxyl, methoxy or acetyl group; is hydrogen or a hydroxyl, methoxy or acetyl group; and R.sup.10 is a methyl group, ##STR2## wherein R.sup.5 is hydrogen or --CH.sub.2 --CH.dbd.C(CH.sub.3).sub.2 ; R.sup.6 is a hydroxyl group; R.sup.10 is hydrogen or a hydroxyl group; R.sup.11 is a hydroxyl or methoxy group; and R.sup.12 is hydrogen or a methyl group. ##STR3##

    Abstract translation: 本发明公开了抑制肿瘤细胞生长的方法，其包括使细胞与生长抑制量的具有以下结构之一的化合物接触：其中R1是羟基或乙酰基; R2是氢，-CH2-CH = C（CH3）2或方法组; R3是羟基，甲氧基或乙酰基; R4是氢，-CH2-CH = C（CH3）2或甲氧基; R5是羟基，甲氧基或乙酰基; 是氢或羟基，甲氧基或乙酰基; 并且R 10是甲基，其中R 5是氢或-CH 2 -CH = C（CH 3）2; R6是羟基; R 10是氢或羟基; R11是羟基或甲氧基; R 12为氢或甲基。

    Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
    5.
    发明授权
    Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives 有权
    芳基和杂芳基 - 喹啉衍生物的合成和抗癌活性

    公开(公告)号：US08524740B2

    公开(公告)日：2013-09-03

    申请号：US13181978

    申请日：2011-07-13

    Applicant: Sheng-Chu Kuo ,  Kuo-Hsiung Lee ,  Li-Jiau Huang ,  Li-Chen Chou ,  Tian-Shung Wu ,  Tzong-Der Way ,  Jing-Gung Chung ,  Jai-Sing Yang ,  Chi-Hung Huang ,  Meng-Tung Tsai

    Inventor： Sheng-Chu Kuo ,  Kuo-Hsiung Lee ,  Li-Jiau Huang ,  Li-Chen Chou ,  Tian-Shung Wu ,  Tzong-Der Way ,  Jing-Gung Chung ,  Jai-Sing Yang ,  Chi-Hung Huang ,  Meng-Tung Tsai

    IPC: A61K31/04 ,  C07D215/04

    CPC classification number: C07D493/04 ,  C07D215/22 ,  C07D215/233 ,  C07D215/38 ,  C07D401/04 ,  C07F9/60 ,  C07F9/65583 ,  C07F9/6561

    Abstract: A compound of Formula I is disclosed as follows: or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R is hydrogen, P(═O)(OH)2, P(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, P(═O)(OH)(OM), P(═O)(OM)2, P═O(O2M), S(═O)(OH)2, S(═O)(O(C1-C18)alkylene(C6-C20)aryl)2, S(═O)(OH)(OM), S(═O)(OM)2; M is a monovalent or divalent metal ion, or alkylammonium ion; W is (C6-C20)aryl, (C6-C20)heteroaryl, (C1-C18)alkyl(C6-C20)aryl, (C1-C18)alkyl(C6-C20)heteroaryl, hydroxy(C6-C20)aryl, hydroxy(C6-C20)heteroaryl, (C1-C18)alkoxy(C6-C20)aryl, (C1-C18)alkoxy(C6-C20)heteroaryl, (C1-C18)alkylenedioxy(C6-C20)aryl, (C1-C18)alkylenedioxy(C6-C20)heteroaryl, halo(C6-C20)aryl, halo(C6-C20)heteroaryl, (C1-C18)alkylamino(C6-C20)aryl, (C1-C18)alkylamino(C6-C20)heteroaryl, (C1-C18)cycloalkylamino(C6-C20)aryl, or (C1-C18)cycloalkylamino(C6-C20)heteroaryl, and their OR8 substutes; R5 is (C1-C18alkoxy, hydrogen, hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, or R5 and R6 are (C1-C18)dioxy provided that R7 is hydrogen; R6 is hydroxyl, O—(C1-C18)alkyl(C6-C20)aryl, halo or OR8, (C1-C18)alkoxy, (C1-C18)alkylamino, or (C1-C18)cycloalkylamino, or R6 and R7 are (C1-C18)dioxy provided that R5 is hydrogen; R7 is hydrogen, halo or OR8, hydroxyl, or O—(C1-C18)alkyl(C6-C20)aryl; and R8 is P(═O)(OH)2, P(═O)(O(C1-C18)alkyl(C6-C20)aryl)2, P(═O)(OH)(OM), or P(═O)(OM)2, P═O(O2M).

    Abstract translation: 式I化合物公开如下：或其药学上可接受的盐，前药，溶剂合物或代谢物，其中R是氢，P（= O）（OH）2，P（= O）（O（C 1 -C 18） ）亚烷基（C 6 -C 20）芳基）2，P（= O）（OH）（OM），P（= O）（OM）2，P = O（O 2 M） S（= O）（O（C1-C18）亚烷基（C6-C20）芳基）2，S（= O）（OH）（OM），S（= O）（OM） M是一价或二价金属离子或烷基铵离子; W是（C 6 -C 20）芳基，（C 6 -C 20）杂芳基，（C 1 -C 18）烷基（C 6 -C 20）芳基，（C 1 -C 18）烷基（C 6 -C 20） 羟基（C 6 -C 20）杂芳基，（C 1 -C 18）烷氧基（C 6 -C 20）芳基，（C 1 -C 18）烷氧基（C 6 -C 20）杂芳基，（C 1 -C 18）亚烷基二氧基 C 1 -C 20烷基氨基（C 6 -C 20）芳基，（C 1 -C 20）芳基，（C 1 -C 20）芳基， 杂芳基，（C1-C18）环烷基氨基（C6-C20）芳基或（C1-C18）环烷基氨基（C6-C20）杂芳基及其OR8分子; R5是（C1-C18烷氧基，氢，羟基，O-（C1-C18）烷基（C6-C20）芳基，卤素或OR8或R5和R6是（C1-C18）二氧基，条件是R7是氢; R6是羟基 ，（C 1 -C 18）烷基（C 6 -C 20）芳基，卤素或OR 8，（C 1 -C 18）烷氧基，（C 1 -C 18）烷基氨基或（C 1 -C 18）环烷基氨基或R 6和R 7为 （C 1 -C 18）烷基（C 6 -C 20）芳基; R 8为P（= O）（OH）2，P（= O） = O）（O（C 1 -C 18）烷基（C 6 -C 20）芳基）2，P（= O）（OH）（OM）或P（= O）（OM）2，P = O（O 2 M）。

    ANALYSIS SYSTEM AND A METHOD FOR PULSE DIAGNOSIS IN CHINESE MEDICINE
    10.
    发明申请
    ANALYSIS SYSTEM AND A METHOD FOR PULSE DIAGNOSIS IN CHINESE MEDICINE 审中-公开
    分析系统和中国医学中脉搏诊断的方法

    公开(公告)号：US20090124914A1

    公开(公告)日：2009-05-14

    申请号：US11937376

    申请日：2007-11-08

    Applicant: Terry B. J. Kuo ,  Cheryl C. H. Yang ,  Hsin-Yo Chen ,  Tian-Shung Wu ,  Hsien-Chang Wu

    Inventor： Terry B. J. Kuo ,  Cheryl C. H. Yang ,  Hsin-Yo Chen ,  Tian-Shung Wu ,  Hsien-Chang Wu

    IPC: A61B5/021

    CPC classification number: A61B5/0402 ,  A61B5/02116 ,  A61B5/022 ,  A61B5/7253 ,  A61B5/7257

    Abstract: The present invention relates to an analysis system and method for pulse diagnosis in Chinese medicine, which analyzes quantitatively the variances of pulse condition, and in particular analyzes the “pulse POSITION”, “pulse PACE”, “pulse FORM” and “pulse DYNAMICS” elements in pulse condition with remarkable increase in the accuracy of pulse diagnosis. The analysis system for pulse diagnosis of the present invention comprises a pulse signal collecting device to collect and generate blood pressure and electrocardiogram signals; and a signal process unit to receive and analyze the blood pressure signal series and electrocardiogram signal series. The execution of the signal process unit includes: establishing the position parameters based on measurement of the blood pressure signals, the heart rate parameters based on calculation of the blood pressure or electrocardiogram signals, the wave form parameters based on analysis of the blood pressure signals, the spectrum analysis parameters based on heart rate variability (HRV) and arterial pressure variability (APV), and the quantitative indexes of the elements in pulse condition of Chinese medicine based on the parameters mentioned above.

    Abstract translation: 本发明涉及一种中医脉搏诊断分析系统及方法，定量分析了脉搏情况的差异，特别分析了“脉搏位置”，“脉冲PACE”，“脉冲形式”，“脉搏动态” 脉冲条件下的元件显着提高了脉搏诊断的准确性。 本发明的脉冲诊断用分析系统包括：收集并产生血压和心电图信号的脉冲信号采集装置; 以及用于接收和分析血压信号序列和心电图信号序列的信号处理单元。 信号处理单元的执行包括：基于血压信号的测量建立位置参数，基于血压或心电图信号的计算的心率参数，基于血压信号分析的波形参数， 基于心率变异性（HRV）和动脉压变异性（APV）的频谱分析参数，以及基于上述参数的中医脉搏状态元素的定量指标。

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