公开(公告)号：US09616139B2

公开(公告)日：2017-04-11

申请号：US14128958

申请日：2012-07-11

申请人： Edward T. Ryan ,  Pavol Kovac ,  Firdausi Qadri ,  Peng Xu ,  Stephen B. Calderwood ,  Willie Frank Vann ,  Dwight Christopher Peterson

发明人： Edward T. Ryan ,  Pavol Kovac ,  Firdausi Qadri ,  Peng Xu ,  Stephen B. Calderwood ,  Willie Frank Vann ,  Dwight Christopher Peterson

IPC分类号： A61K38/02 ,  A61K47/48 ,  A61K39/02 ,  C08B37/00 ,  C08H1/00 ,  C08L89/00 ,  A61K9/00 ,  A61K39/08 ,  A61K39/00

CPC分类号： A61K47/4833 ,  A61K9/0019 ,  A61K39/08 ,  A61K39/107 ,  A61K47/646 ,  A61K2039/55544 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C08B37/00 ,  C08H1/00 ,  C08L89/00 ,  Y02A50/472 ,  Y02A50/478 ,  Y02A50/484

摘要： The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.

公开(公告)号：US20170160275A1

公开(公告)日：2017-06-08

申请号：US15368545

申请日：2016-12-02

申请人： FIRDAUSI QADRI ,  JAKIA AMIN

发明人： FIRDAUSI QADRI ,  JAKIA AMIN

IPC分类号： G01N33/558 ,  G01N33/553 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/558 ,  G01N33/56916 ,  G01N2469/20 ,  Y02A50/59

摘要： The blood-based lateral-flow dipstick assay for detection of enteric fever is an immunochromatographic dipstick assay based on detection of Salmonella enterica serovar Typhi (S. Typhi) LPS-specific IgG in lymphocyte culture secretion. The dipstick has a test line of an S. Typhi strain antigen extending across a chromatographic stationary phase disposed on a backing, A conjugate pad of glass fibers is attached to the backing so that it overlaps the stationary phase. The conjugate pad is soaked in a first mammal's anti-human antibody (e.g., goat anti-human IgG) conjugated with a color indicator (e.g., colloidal gold nanoparticles exhibiting a wine red color). When dipped in a lymphocyte culture of a human enteric fever victim, the test line turns to the color of the color indicator. A control line of anti-first mammal antibody across the stationary phase changes to the color of the indicator so long as the conjugated anti-human antibody remains viable.

公开(公告)号：US20150031863A1

公开(公告)日：2015-01-29

申请号：US14128958

申请日：2012-07-11

申请人： Edward T. Ryan ,  Pavol Kovac ,  Firdausi Qadri ,  Peng Xu ,  Stephen B. Calderwood ,  Willie Frank Vann ,  Dwight Christopher Peterson

发明人： Edward T. Ryan ,  Pavol Kovac ,  Firdausi Qadri ,  Peng Xu ,  Stephen B. Calderwood ,  Willie Frank Vann ,  Dwight Christopher Peterson

IPC分类号： A61K47/48 ,  A61K39/02 ,  A61K39/08

CPC分类号： A61K47/4833 ,  A61K9/0019 ,  A61K39/08 ,  A61K39/107 ,  A61K47/646 ,  A61K2039/55544 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C08B37/00 ,  C08H1/00 ,  C08L89/00 ,  Y02A50/472 ,  Y02A50/478 ,  Y02A50/484

摘要： The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.

摘要翻译： 本公开内容提供直接缀合的多糖疫苗分子及其相关方法。