公开(公告)号：US5916901A

公开(公告)日：1999-06-29

申请号：US79935

申请日：1998-05-15

申请人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

发明人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

IPC分类号： C07D321/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4406 ,  A61K31/55 ,  A61P3/08 ,  A61P25/00 ,  A61P29/00 ,  C07D273/00 ,  C07D273/01 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  A61K31/47 ,  C07D215/04

CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US6017915A

公开(公告)日：2000-01-25

申请号：US79599

申请日：1998-05-15

申请人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

发明人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

IPC分类号： C07D321/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4406 ,  A61K31/55 ,  A61P3/08 ,  A61P25/00 ,  A61P29/00 ,  C07D273/00 ,  C07D273/01 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  A61K31/535 ,  C07D413/12

CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

摘要翻译： 本发明涉及新型N-取代氨基醇，氨基酸及其酸衍生物，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用途 用于临床治疗C型纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用的疼痛，痛觉过敏和/或炎性疾病。

公开(公告)号：US5912262A

公开(公告)日：1999-06-15

申请号：US957163

申请日：1997-10-24

申请人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

发明人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

IPC分类号： C07D321/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4406 ,  A61K31/55 ,  A61P3/08 ,  A61P25/00 ,  A61P29/00 ,  C07D273/00 ,  C07D273/01 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  A61K31/40

CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US5917047A

公开(公告)日：1999-06-29

申请号：US957172

申请日：1997-10-24

申请人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

发明人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

IPC分类号： C07D321/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4406 ,  A61K31/55 ,  A61P3/08 ,  A61P25/00 ,  A61P29/00 ,  C07D273/00 ,  C07D273/01 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  A61K31/44

CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US5753678A

公开(公告)日：1998-05-19

申请号：US715665

申请日：1996-09-18

申请人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

发明人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

IPC分类号： C07D321/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4406 ,  A61K31/55 ,  A61P3/08 ,  A61P25/00 ,  A61P29/00 ,  C07D273/00 ,  C07D273/01 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  A61K31/445 ,  C07D211/06

CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US6004983A

公开(公告)日：1999-12-21

申请号：US943501

申请日：1997-10-03

申请人： Henrik Sune Andersen ,  Tine Krogh J.o slashed.rgensen ,  Rolf Hohlweg ,  Knud Erik Andersen ,  Zdenek Polivka ,  Frantisek Miksik

发明人： Henrik Sune Andersen ,  Tine Krogh J.o slashed.rgensen ,  Rolf Hohlweg ,  Knud Erik Andersen ,  Zdenek Polivka ,  Frantisek Miksik

IPC分类号： A61K31/38 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/4535 ,  A61P3/08 ,  A61P17/04 ,  A61P25/06 ,  A61P29/00 ,  C07D207/08 ,  C07D211/60 ,  C07D211/62 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06 ,  C07D211/34

CPC分类号： C07D207/08 ,  C07D211/60 ,  C07D211/62 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxcylic acids of the general formula wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.

摘要翻译： 本发明涉及以下通式的新型N-取代的氮杂环状羧酸：其中X，Y，Z，R 1，R 2和r如说明书的详细部分所定义，或其盐，其制备方法， 含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由或由 胰岛素拮抗肽的分泌和循环。

公开(公告)号：US5972925A

公开(公告)日：1999-10-26

申请号：US922977

申请日：1997-09-04

申请人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

发明人： Rolf Hohlweg ,  Tine Krogh J.o slashed.rgensen ,  Knud Erik Andersen ,  Uffe Bang Olsen ,  Peter Madsen ,  Zdenek Polivka ,  Otylie Konigova ,  Frantisek Miksik ,  Martina Kovandova ,  Alexandra Silhankova ,  Karel Sindelar

IPC分类号： C07D321/12 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4406 ,  A61K31/55 ,  A61P3/08 ,  A61P25/00 ,  A61P29/00 ,  C07D273/00 ,  C07D273/01 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  A61K31/395

CPC分类号： C07D405/06 ,  C07D405/12 ,  C07D413/06

摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US4243805A

公开(公告)日：1981-01-06

申请号：US972323

申请日：1978-12-22

申请人： Miroslav Protiva ,  Miroslav Rajsner ,  Karel Sindelar ,  Jiri Jilek ,  Vaclav Bartl ,  Jirina Metysova ,  Antonin Dlabac ,  Leon Langsadl ,  Josef Pomykacek ,  Frantisek Miksik

发明人： Miroslav Protiva ,  Miroslav Rajsner ,  Karel Sindelar ,  Jiri Jilek ,  Vaclav Bartl ,  Jirina Metysova ,  Antonin Dlabac ,  Leon Langsadl ,  Josef Pomykacek ,  Frantisek Miksik

IPC分类号： A61K31/38 ,  A61K31/495 ,  A61K31/55 ,  A61P25/00 ,  A61P25/26 ,  A61P31/04 ,  C07C17/093 ,  C07C17/14 ,  C07C51/08 ,  C07D295/073 ,  C07D295/088 ,  C07D295/092 ,  C07D295/205 ,  C07D337/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14

CPC分类号： C07D295/073 ,  C07C17/093 ,  C07C17/14 ,  C07C323/00 ,  C07C51/08 ,  C07D295/088 ,  C07D295/205 ,  C07D337/14

摘要： Techniques for the preparation of 3-fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(b,f) thiepins and their addition salts with organic and inorganic acids are disclosed. The described compositions evidence psychotropic activity and low toxicity and are characterized as neuroliptics with a high degree of cataleptic, anti-apomorphine and central depressant action.

摘要翻译： 公开了制备3-氟-10-哌嗪基-8-取代的10,11-二氢二苯并 - （b，f）硫蛋白及其与有机和无机酸的加成盐的技术。 所描述的组合物表现出精神活性和低毒性，并且被表征为具有高程度的抗痴呆，抗阿扑吗啡和中枢抑制作用的神经元。