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公开(公告)号：US08518999B2
公开(公告)日：2013-08-27
申请号：US11292325
申请日：2005-12-01
申请人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
发明人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
IPC分类号： A61K31/16 , A61K31/4174 , A61K31/436 , A61K31/395 , A61K45/06 , A61P37/06 , C07C233/00 , C07D233/54
CPC分类号： A61K31/53 , C07D233/64 , C07D401/14 , C07D403/14
摘要： The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
摘要翻译： 本发明提供了作为TNF-α信号调节剂的化合物及其用于治疗患有TNF-α介导病症的患者的方法。 该化合物可以由以下结构式表示：
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公开(公告)号：US20060173010A1
公开(公告)日：2006-08-03
申请号：US11292325
申请日：2005-12-01
申请人： Scott Sneddon , John Kane , Bradford Hirth , Fred Vinick , Shuang Qiao , Sharon Nahill , John Williams , Hans-Peter Biemann
发明人： Scott Sneddon , John Kane , Bradford Hirth , Fred Vinick , Shuang Qiao , Sharon Nahill , John Williams , Hans-Peter Biemann
IPC分类号： A61K31/498 , A61K31/497 , A61K31/4965 , A61K31/4439 , A61K31/4172 , C07D403/02
CPC分类号： A61K31/53 , C07D233/64 , C07D401/14 , C07D403/14
摘要： The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
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公开(公告)号：US07034031B2
公开(公告)日：2006-04-25
申请号：US10797244
申请日：2004-03-10
申请人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
发明人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P19/02 , A61P25/28
CPC分类号： A61K31/53 , C07D233/64 , C07D401/14 , C07D403/14
摘要： The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
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公开(公告)号：US06410533B1
公开(公告)日：2002-06-25
申请号：US09502101
申请日：2000-02-10
申请人： Bradford H. Hirth , Andrew Janjigian , Fred Vinick
发明人： Bradford H. Hirth , Andrew Janjigian , Fred Vinick
IPC分类号： A61K314439
CPC分类号： C07D401/04 , C07D231/22 , C07D231/40 , C07D277/48
摘要： The present invention provides compounds having useful antibacterial activity and pharmaceutical compositions comprising one or more of these compounds. The invention further relates to a method of treating a bacterial infection in a patient, comprising administering to the patient an effective mount of one or more of the antibacterial compounds of the invention.
摘要翻译： 本发明提供具有有用抗菌活性的化合物和包含一种或多种这些化合物的药物组合物。 本发明还涉及一种治疗患者细菌感染的方法，包括向患者施用本发明的一种或多种抗菌化合物的有效载体。
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公开(公告)号：US06969728B2
公开(公告)日：2005-11-29
申请号：US09852965
申请日：2001-05-10
申请人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
发明人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
IPC分类号： C07D295/14 , A61K31/277 , A61K31/405 , A61K31/417 , A61K31/4178 , A61K31/4439 , A61K31/444 , A61K31/498 , A61K31/506 , A61K31/53 , A61K31/5375 , A61K31/5377 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P9/10 , A61P9/14 , A61P19/02 , A61P21/04 , A61P25/14 , A61P25/28 , A61P25/32 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07C255/60 , C07D233/54 , C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07C233/00 , A61K38/05 , A61K38/06 , A61K38/07
CPC分类号： A61K31/53 , C07D233/64 , C07D401/14 , C07D403/14
摘要： The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
摘要翻译： 本发明提供了作为TNF-α信号调节剂的化合物及其用于治疗患有TNF-α介导病症的患者的方法。 该化合物可以由以下结构式表示：
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