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公开(公告)号：US4439359A
公开(公告)日：1984-03-27
申请号：US394750
申请日：1982-07-02
申请人： Frederick W. Holly, deceased , Marcia E. Christy , Kenneth L. Shepard , Robert G. Strachan , Sandor L. Varga , Daniel F. Veber
发明人： Frederick W. Holly, deceased , Marcia E. Christy , Kenneth L. Shepard , Robert G. Strachan , Sandor L. Varga , Daniel F. Veber
IPC分类号： C07K7/08 , C07C103/52
CPC分类号： C07K7/083 , Y10S930/27
摘要： There are disclosed cyclic octapeptide analogs of the tridecapeptide, neurotensin.
摘要翻译： 公开了十三肽，神经降压素的环状八肽类似物。
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公开(公告)号：US4161521A
公开(公告)日：1979-07-17
申请号：US695348
申请日：1976-06-14
申请人： Daniel F. Veber , Frederick W. Holly , Robert G. Strachan , William J. Paleveda , Ruth F. Nutt , Ralph F. Hirschmann
发明人： Daniel F. Veber , Frederick W. Holly , Robert G. Strachan , William J. Paleveda , Ruth F. Nutt , Ralph F. Hirschmann
IPC分类号： A61K38/00 , C07K5/103 , C07K14/655 , A61K37/00 , C07C103/52
CPC分类号： C07K14/6555 , C07K5/1013 , A61K38/00 , Y10S514/806 , Y10S930/16
摘要： Somatostatin analogs having the structural formula: ##STR1## are prepared by controlled stepwise procedures starting with individual amino acid components. These peptides have the property of lowering blood glucose, inhibiting gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
摘要翻译： 具有结构式：
+ tr 和 + tr 的生长抑素类似物通过从各个氨基酸组分开始的受控逐步程序制备。 这些肽具有降低血糖，抑制胃分泌，抑制生长激素释放和抑制人和动物中胰高血糖素释放的性质。 -
公开(公告)号：US3971736A
公开(公告)日：1976-07-27
申请号：US542884
申请日：1975-01-21
摘要： Hexa- and heptapeptides of formula W-[X-Pro-Phe-Phe-Y-Z].sub.n H prepared by standard synthetic peptide techniques are anti-inflammatory, anti-rheumatoid arthritic and anti-ulcer agents.
摘要翻译： 通过标准合成肽技术制备的式W- [X-Pro-Phe-Phe-Y-Z] nH的六肽和七肽是抗炎，抗类风湿关节炎和抗溃疡剂。
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公开(公告)号：US3959248A
公开(公告)日：1976-05-25
申请号：US543734
申请日：1975-01-27
IPC分类号： C07K5/08 , A61K38/04 , A61P5/12 , A61P25/26 , C07D233/32 , C07K1/113 , C07K5/097 , C07K14/575 , C07C103/52 , A61K37/00
CPC分类号： C07K5/0821 , C07D233/32
摘要： Novel tripeptides are disclosed. These tripeptides have anti-depressant activity and thyrotropin releasing hormone activity. Processes for preparing these tripeptides are also disclosed.
摘要翻译： 公开了新颖的三肽。 这些三肽具有抗抑郁活性和促甲状腺激素释放激素活性。 还公开了制备这些三肽的方法。
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公开(公告)号：US4162248A
公开(公告)日：1979-07-24
申请号：US894266
申请日：1978-04-07
IPC分类号： A61K38/00 , C07K14/655 , A61K37/02 , C07C103/52
CPC分类号： C07K14/6555 , A61K38/00 , Y10S514/806 , Y10S930/16
摘要： Somatostatin analogs having the structural formula:Cyclo[(X).sub.j -(A).sub.k -(B).sub.1 -Phe-Phe-(D- or L-)Trp-Lys-Thr-Phe-Thr-(C).sub.m ]WhereinX is ##STR1## and n=0 to 4; A is Lys, (.epsilon.-INOC) Lysine;B is Asn, Ala, .alpha.-aminobutyric acid;C is Ser, Gly;J, k, l and m are 0 to 1; with the proviso that j, k, l, and m are not all 1 and not all 0,Wherein the ring formed by the peptide backbone contains 24 to 33 atoms and the pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, decreasing gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
摘要翻译： 具有以下结构式的生长抑素类似物：
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公开(公告)号：US4130554A
公开(公告)日：1978-12-19
申请号：US566150
申请日：1975-04-08
IPC分类号： A61K38/00 , C07K14/655 , C07C103/52 , A61K37/00
CPC分类号： C07K14/655 , A61K38/00 , Y10S514/806 , Y10S930/16
摘要： Somatostatin analog, hereinafter designated des(Ala.sup.1 -Gly.sup.2)desaminocys.sup.3 -somatostatin, having the structure: ##STR1## is prepared by controlled stepwise procedures starting with individual amino acid components. This peptide has the property of lowering blood glucose, inhibiting gastric secretion and inhibiting growth hormone release in humans and animals.
摘要翻译： 具有以下结构的生长抑素类似物（以下称为des（Ala1-Gly2）desaminocys3-生长抑素）通过以个别氨基酸组分开始的受控逐步程序制备。 该肽具有降低血糖，抑制胃分泌和抑制人和动物中生长激素释放的性质。
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