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公开(公告)号：US20110237547A1
公开(公告)日：2011-09-29
申请号：US13155048
申请日：2011-06-07
申请人： Friedrich Karl Mayer
发明人： Friedrich Karl Mayer
CPC分类号： A61K31/69 , A61K31/137 , A61K45/06 , A61K2300/00
摘要： Synergistic combinations of a squalene epoxidase inhibitor and a leucyl-tRNA synthetase inhibitor are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin or nail plays a role, such as atopic dermatitis, acne vulgaris, seborrhoeic dermatitis, rosacea or onychomycosis, and in situations of fungal resistance.
摘要翻译： 提供了角鲨烯环氧酶抑制剂和亮氨酰-tRNA合成酶抑制剂的协同组合，其特别可用于治疗涉及真菌或疑似真菌感染的疾病，用于在真菌或疑似真菌定植的病例中进行免疫调节或免疫抑制。 皮肤或指甲发挥作用，如特应性皮炎，寻常型痤疮，脂溢性皮炎，酒渣鼻或甲癣，以及真菌感染的情况。
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公开(公告)号：US20080286356A1
公开(公告)日：2008-11-20
申请号：US12218806
申请日：2008-07-18
申请人： Rainer Alles , Dieter Becker , Jean-Daniel Bonny , Stefan Hirsch , Oskar Kalb , Ernst Ulrich Kolle , Friedrich Karl Mayer , Anton Stutz , Anthony Williams
发明人： Rainer Alles , Dieter Becker , Jean-Daniel Bonny , Stefan Hirsch , Oskar Kalb , Ernst Ulrich Kolle , Friedrich Karl Mayer , Anton Stutz , Anthony Williams
IPC分类号： A61K9/48 , A61K31/135 , A61K9/28 , A61K9/14 , A61P31/10 , C07C211/30 , A61K9/32 , A61K9/36
CPC分类号： A61K9/2846 , A61K9/2054 , A61K9/4808 , A61K31/135
摘要： Pharmaceutical compositions for oral administration comprising terbinafine and a method for administering high dosages while minimizing effects associated with e.g. a high dosage load, e.g. coated tablets or multiparticulate formulations such as minitablets or pellets, e.g. in capsules.
摘要翻译： 用于口服给药的药物组合物，其包含特比萘芬，以及用于施用高剂量同时最小化与例如血浆相关的影响的方法。 高剂量负荷，例如 包衣片剂或多颗粒制剂，例如微型药丸或丸剂，例如。 胶囊。
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公开(公告)号：US20080132534A1
公开(公告)日：2008-06-05
申请号：US11973849
申请日：2007-10-10
IPC分类号： A61K31/4353 , A61K8/68 , A61P17/00
CPC分类号： A61K31/164 , A61K39/39 , A61K2300/00
摘要： Snyergistic combination of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a ceramide such as ceramide 3, LPC-9S or linoleic acid are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as atopic or contact dermatitis or dry skin, asteatotic eczema or xerosis.
摘要翻译： 提供大环内酯类T细胞免疫调节剂或免疫抑制剂如33-表氯-3-脱氧菌丝霉素和神经酰胺如神经酰胺3，LPC-9S或亚油酸的综合组合，其特别用于治疗皮肤病学或粘膜疾病 如特应性或接触性皮炎或干性皮肤，硬皮病湿疹或干性病。
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公开(公告)号：US10525003B2
公开(公告)日：2020-01-07
申请号：US11992823
申请日：2006-09-27
申请人： Friedrich Karl Mayer
发明人： Friedrich Karl Mayer
IPC分类号： A61K9/06 , A61K31/137 , A61K31/5375 , A61K47/32 , A61K47/38 , A61K9/00 , A61K9/70
摘要： The invention provides a topical liquid antifungal composition containing an antifungal agent, a film-forming agent and a solvent. The composition is applied on the infected skin area to form a film that delivers the active agent. The invention also provides a method for treating a fungal infection on the skin by applying the topical antifungal composition that forms a film on the skin.
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公开(公告)号：US20090088434A1
公开(公告)日：2009-04-02
申请号：US11992823
申请日：2006-09-27
申请人： Friedrich Karl Mayer
发明人： Friedrich Karl Mayer
IPC分类号： A61K31/135 , A61K31/5375
摘要： The invention provides a topical liquid antifungal composition containing an antifungal agent, a film-forming agent and a solvent. The composition is applied on the infected skin area to form a film that delivers the active agent. The invention also provides a method for treating a fungal infection on the skin by applying the topical antifungal composition that forms a film on the skin.
摘要翻译： 本发明提供含有抗真菌剂，成膜剂和溶剂的局部液体抗真菌组合物。 将组合物施用于受感染的皮肤区域以形成递送活性剂的膜。 本发明还提供了一种通过将在皮肤上形成膜的局部抗真菌组合物施用来治疗皮肤上的真菌感染的方法。
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6.发明授权Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator 失效包含角鲨烯环氧酶抑制剂和大环内酯类免疫调节剂的药物组合物公开(公告)号：US06919317B2
公开(公告)日：2005-07-19
申请号：US10204027
申请日：2001-02-16
IPC分类号： A61K45/06 , A61K31/137 , A61K31/35 , A61K31/4353 , A61P31/10 , A61P37/02 , A61P43/00 , A01N43/04 , A01N33/02 , A61K31/135 , A61K31/70
CPC分类号： A61K31/35 , A61K31/135 , A61K2300/00
摘要： Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin plays a role, such as atopic dermatitis and seborrhoeic dermatitis, and in situations of fungal resistance.
摘要翻译： 提供角鲨烯环氧酶抑制剂如特比萘芬和大环内酯类T细胞免疫调节剂或免疫抑制剂如33-表氯-3-脱氧霉菌素的协同组合，其特别用于治疗涉及真菌或疑似真菌感染的疾病，用于免疫调节 或在真菌或疑似真菌定殖的条件下的免疫抑制 皮肤发挥作用，如特应性皮炎和脂溢性皮炎，以及真菌感染的情况。
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公开(公告)号：US20090221625A1
公开(公告)日：2009-09-03
申请号：US11912372
申请日：2006-04-27
申请人： Stefan Hirsch , Katrin Kriwet , Dorothea Ledergerber , Friedrich Karl Mayer , Nabila Sekkat , Kurt Schmidt , Wanda Richard
发明人： Stefan Hirsch , Katrin Kriwet , Dorothea Ledergerber , Friedrich Karl Mayer , Nabila Sekkat , Kurt Schmidt , Wanda Richard
IPC分类号： A61K31/4745 , A61K31/08 , A61K31/20 , A61P17/00 , A61P17/16
摘要： Topical compositions comprising: —a physiologically acceptable alkanediol, ether diol or diether alcohol containing up to (8) carbon atoms; —water; and—optionally an unsaturated fatty alcohol; and optionally further conventional excipients, for use as a cosmeceutical, in particular for use in the repair or maintenance of skin barrier function. They are indicated for use in e.g. moisturizing skin, nail and mucosa and, when an optional pharmaceutically active agent is present, additionally in the treatment of various skin, nail and mucosal diseases. Also disclosed are compositions suitable for topical application to infants and babies for treating dry skin, and soothing skin irritated from diaper rash and scrapes.
摘要翻译： 包括： - 生理上可接受的链烷二醇，醚二醇或含有至多（8）个碳原子的二醚醇; -水; 和任选的不饱和脂肪醇; 和任选的其它常规赋形剂，用作药妆，特别是用于修复或维持皮肤屏障功能。 它们被指示用于例如 保湿皮肤，指甲和粘膜，并且当存在任选的药物活性剂时，另外用于治疗各种皮肤，指甲和粘膜疾病。 还公开了适用于局部应用于婴儿和婴儿以治疗干性皮肤的组合物，以及舒缓从尿布疹和刮擦刺激的皮肤的组合物。
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