公开(公告)号：US20240279403A1

公开(公告)日：2024-08-22

申请号：US18565147

申请日：2023-04-28

申请人： The University of Tokyo ,  GELLYCLE CO., LTD.

发明人： Takamasa SAKAI ,  Mitsuru NAITO ,  Takuya KATASHIMA ,  Kosuke MASUI ,  Hiroyuki KAMATA

IPC分类号： C08G81/00 ,  C08G65/337

CPC分类号： C08G81/00 ,  C08G65/337

摘要： An object is to provide a novel artificial slime-like polymer material having stability against an external solvent without changing the chemical composition of a main chain skeleton, a solvent, and the like constituting the polymer material and without impairing the viscosity and elasticity of the slime-like material.
It has been found that by controlling the number of branches, terminal connectivity, and concentration of polymer units constituting the polymer material, it is possible to provide a slime-like polymer material that induces liquid-liquid phase separation and thereby control solubility in external solvents.

公开(公告)号：US20240294746A1

公开(公告)日：2024-09-05

申请号：US18565153

申请日：2023-04-28

申请人： The University of Tokyo ,  GELLYCLE CO., LTD.

发明人： Takamasa SAKAI ,  Mitsuru NAITO ,  Takuya KATASHIMA ,  Kosuke MASUI ,  Hiroyuki KAMATA

IPC分类号： C08L51/08 ,  C08F8/42 ,  C08F283/06

CPC分类号： C08L51/08 ,  C08F8/42 ,  C08F283/06 ,  C08L2201/54 ,  C08L2205/025 ,  C08L2205/04

摘要： [Object]
An object of the present invention is to provide a novel artificial slime-like polymer material capable of controlling flow characteristics without changing a chemical composition such as a main chain skeleton or a solvent constituting the polymer material.
[Solution]
It is found that a slime-like polymer material in which liquid-liquid phase separation is induced can be provided and fluidity of the polymer material can be controlled by adding a polymer that does not react with a polymer unit serving as a basic skeleton constituting the polymer material in addition to the polymer unit.

公开(公告)号：US20220331439A1

公开(公告)日：2022-10-20

申请号：US17628676

申请日：2020-07-27

申请人： The University of Tokyo

发明人： Kanjiro MIYATA ,  Beob Soo KIM ,  Shigehito OSAWA ,  Mitsuru NAITO ,  Hiroyuki CHAYA

IPC分类号： A61K47/61 ,  A61K9/107 ,  A61K47/54 ,  A61K47/55

摘要： A drug-polymer conjugate having thermoresponsiveness includes at least one drug conjugated to at least one end portion of at least one thermoresponsive polymer segment having a lower critical solution temperature. The drug-polymer conjugate is capable of forming a micellular aggregate in an aqueous medium at temperatures equal to or above the lower critical solution temperature. The drug-polymer conjugate or the micellular aggregate thereof may be administered to and absorbed in the lungs.

公开(公告)号：US20230414765A1

公开(公告)日：2023-12-28

申请号：US18463711

申请日：2023-09-08

申请人： AGC INC. ,  THE UNIVERSITY OF TOKYO ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

发明人： Mihoko HARA ,  Rintaro HARA ,  Kanjiro MIYATA ,  Mitsuru NAITO ,  Takanori YOKOTA

IPC分类号： A61K47/59 ,  C08G69/48 ,  A61K47/60

CPC分类号： A61K47/595 ,  C08G69/48 ,  A61K47/60

摘要： A polymer represented by the following formula (I):




wherein each symbol is as described in the specification, is useful as a drug carrier in effectively delivering a drug to a target site.

公开(公告)号：US20210346290A1

公开(公告)日：2021-11-11

申请号：US17251521

申请日：2019-06-13

申请人： KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION ,  THE UNIVERSITY OF TOKYO

发明人： Yasutaka ANRAKU ,  Kazunori KATAOKA ,  Shigeto FUKUSHIMA ,  Kanjiro MIYATA ,  Hyun Su MIN ,  Mitsuru NAITO

IPC分类号： A61K9/107 ,  A61K31/7088 ,  A61K47/34 ,  A61K9/00 ,  A61P3/08

摘要： The present invention provides a polyion complex micelle including an antisense oligonucleotide and a block copolymer of a cationic polymer and a PEG block having a number average molecular weight of 3 kDa to 10 kDa.