公开(公告)号：US08722690B2

公开(公告)日：2014-05-13

申请号：US13386065

申请日：2010-08-03

Applicant: Wenming Zhang ,  Caleb William Holyoke, Jr. ,  Kenneth Andrew Hughes ,  George Philip Lahm ,  Thomas Francis Pahutski, Jr. ,  My-Hanh Thi Tong ,  Ming Xu

Inventor： Wenming Zhang ,  Caleb William Holyoke, Jr. ,  Kenneth Andrew Hughes ,  George Philip Lahm ,  Thomas Francis Pahutski, Jr. ,  My-Hanh Thi Tong ,  Ming Xu

IPC: A61K31/519 ,  C07D239/70

CPC classification number: A01N43/90 ,  A01N25/00 ,  A01N43/54 ,  A01N43/78 ,  A61K31/519 ,  C07D239/54 ,  C07D401/06 ,  C07D417/06 ,  C07D471/04 ,  C07D487/04 ,  C07D495/14 ,  C07D498/04 ,  C07D513/04

Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein X is O or S; Y is O or S; A is O, S, NR3e or C(R3c)═C(R3d); Z is a direct bond, O, S(O)n, NR6, C(R7)2O, OC(R7)2, C(═X1), C(═X1)E, EC(═X1), C(═NOR8) or C(═NN(R6)2); a is 1, 2 or 3; and R1, R2, R3a-R3e, R4, R5, R6, R7, R8, X1 and E are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，N-氧化物及其盐，其中X是O或S; Y为O或S; A是O，S，NR 3e或C（R 3c）= C（R 3d）; Z是直接键，O，S（O）n，NR6，C（R7）2O，OC（R7）2，C（= X1），C（= X1）E，EC（═X1），C NOR8）或C（= NN（R6）2）; a是1,2或3; 并且R1，R2，R3a-R3e，R4，R5，R6，R7，R8，X1和E如本公开所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US08623890B2

公开(公告)日：2014-01-07

申请号：US13264159

申请日：2010-05-04

Applicant: George Philip Lahm ,  Renee M. Lett ,  Brenton Todd Smith ,  Benjamin Kenneth Smith ,  C. Anne Daly

Inventor： George Philip Lahm ,  Renee M. Lett ,  Brenton Todd Smith ,  Benjamin Kenneth Smith ,  C. Anne Daly

IPC: A01N43/42 ,  A61K31/44 ,  C07D491/02 ,  C07D498/02

CPC classification number: A01N55/00 ,  A01N43/90

Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; and R1, R2, R3, Q and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.

公开(公告)号：US20110293533A1

公开(公告)日：2011-12-01

申请号：US13207669

申请日：2011-08-11

Applicant: Isaac Billy Annan ,  John Lindsey Flexner ,  Hector Eduardo Portillo ,  George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： Isaac Billy Annan ,  John Lindsey Flexner ,  Hector Eduardo Portillo ,  George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: A01N43/56 ,  A01N57/16 ,  A01N43/68 ,  A01N43/54 ,  A01M1/10 ,  A01N43/58 ,  A01N43/707 ,  A01N25/02 ,  A01P7/04 ,  A01M1/20 ,  A01N43/88 ,  A01N43/90

CPC classification number: A01N43/56 ,  A01N2300/00

Abstract: Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a) 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide, and its N-oxides, and suitable salts thereof and a component (b) wherein the component (b) is at least one compound or agent selected from neonicotinoids, cholinesterase inhibitors, sodium channel modulators, chitin synthesis inhibitors, ecdysone agonists, lipid biosynthesis inhibitors, macrocyclic lactones, GABA-regulated chloride channel blockers, juvenile hormone mimics, ryanodine receptor ligands, octopamine receptor ligands, mitochondrial electron transport inhibitors, nereistoxin analogs, pyridalyl, flonicamid, pymetrozine, dieldrin, metaflumizone, biological agents, and suitable salts of the foregoing. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a mixture or composition of the invention.

Abstract translation: 公开了用于控制与（a）3-溴-N- [4-氯-2-甲基-6 - [（甲基氨基）羰基]苯基] -1-（3-氯-2 - 吡啶基）-1H-吡唑-5-甲酰胺及其N-氧化物及其合适的盐和组分（b），其中组分（b）是至少一种选自新烟碱类，胆碱酯酶抑制剂，钠通道的化合物或药剂 调节剂，壳多糖合成抑制剂，蜕皮激素激动剂，脂质生物合成抑制剂，大环内酯，GABA调节的氯化物通道阻断剂，幼年激素模拟物，兰诺定受体配体，章鱼胺受体配体，线粒体电子传递抑制剂，奈司毒素类似物，吡啶甲酰，氟虫胺，吡蚜酮，狄氏剂 ，间氟lum嗪，生物制剂和上述的合适的盐。 还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物有效量的本发明的混合物或组合物接触。

公开(公告)号：US07964204B2

公开(公告)日：2011-06-21

申请号：US12086935

申请日：2006-12-28

Applicant: George Philip Lahm ,  Wesley Lawrence Shoop ,  Ming Xu

Inventor： George Philip Lahm ,  Wesley Lawrence Shoop ,  Ming Xu

IPC: C07D261/04 ,  C07D251/72 ,  C07D253/08 ,  C07D239/26 ,  C07D239/74 ,  C07D237/26 ,  C07D235/04 ,  C07D217/04 ,  C07D213/46 ,  C07D221/04 ,  A61K31/422 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/47 ,  A61K31/496 ,  A61K31/53 ,  A01N25/02 ,  A01N25/08

CPC classification number: A01N43/42 ,  A01M1/10 ,  A01M1/2005 ,  A01N43/80 ,  A61K9/1075 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4725 ,  A61K45/06 ,  C07D215/12 ,  C07D261/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K2300/00

Abstract: Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof, Formula (1): wherein A1, A2, A3, A4, A5 and A6 are independently, selected from the group consisting of CR3 and N; provided that at most 3 of A1, A2, A3; A4, A5 and A6 is N; B1, B2 and B3 are independently selected from the group consisting of CR2. and N; each R3 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfo?yl, C1-C6 alkylamino, C2-G6 dialkylamino, —CN or —NO2; and R1, R2, R4, R5, W and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式（1）的化合物，其包括所有几何和立体异构体，N-氧化物及其盐，式（1）：其中A1，A2，A3，A4，A5和A6独立地选自CR3 和N; 只要A1，A2，A3中至多3个; A4，A5和A6为N; B1，B2和B3独立地选自CR2。 和N; 每个R 3独立地是H，卤素，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6环烷基，C 3 -C 6卤代环烷基，C 1 -C 6烷氧基，C 1 -C 6卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基， C6烷基亚磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基磺酰基，C1-C6卤代烷基亚磺酰基，C1-C6烷基氨基，C2-G6二烷基氨基，-CN或-NO2; 并且R1，R2，R4，R5，W和n如本公开所定义。 还公开了含有式（1）化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US20110124857A1

公开(公告)日：2011-05-26

申请号：US13017322

申请日：2011-01-31

Applicant: GEORGE PHILIP LAHM ,  THOMAS PAUL SELBY ,  THOMAS MARTIN STEVENSON

Inventor： GEORGE PHILIP LAHM ,  THOMAS PAUL SELBY ,  THOMAS MARTIN STEVENSON

IPC: C07D265/22

CPC classification number: A01N43/56 ,  A01N37/38 ,  A01N43/16 ,  A01N43/707 ,  C07C251/76 ,  C07D213/77 ,  C07D231/06 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure. Also disclosed are methods for controlling invertebrate pests comprising contacting the invertebrate pests or their environment with a biologically effective amount of a compound of Formula 1 or a composition comprising a compound of Formula 1.

Abstract translation: 本发明提供式1化合物，其N-氧化物和农业上合适的盐，其中R1，R2，R3，R4a，R4b和R5如本公开所定义。 还公开了用于控制无脊椎动物害虫的方法，包括使无脊椎害虫或其环境与生物有效量的式1化合物或包含式1化合物的组合物接触。

公开(公告)号：US20100152194A1

公开(公告)日：2010-06-17

申请号：US12711285

申请日：2010-02-24

Applicant: Richard Alan Berger ,  Isaac Billy Annan ,  John Lindsey Flexner ,  George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： Richard Alan Berger ,  Isaac Billy Annan ,  John Lindsey Flexner ,  George Philip Lahm ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: A01N43/56 ,  A01N43/58 ,  A01N43/54 ,  A01P3/00 ,  A01P7/00

CPC classification number: A01N43/56 ,  A01N43/54 ,  A01N43/58 ,  A01N43/86 ,  A01N25/24 ,  A01N25/10 ,  A01N2300/00

Abstract: This invention pertains to methods for protecting a propagule or a plant grown therefrom from invertebrate pests comprising contacting the propagule or the locus of the propagule with a biologically effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention also relates to propagules treated with a compound of Formula I and compositions comprising a Formula I compound for coating propagules.

Abstract translation: 本发明涉及用于保护繁殖体或从无脊椎动物害虫生长的植物的方法，包括使生殖有效量的式I化合物，其N-氧化物或农业上合适的盐使繁殖体的繁殖体或基因座接触，其中 A和B以及R 1至R 8如本公开中所定义。 本发明还涉及用式I化合物处理的繁殖体和包含用于包被繁殖体的式I化合物的组合物。

公开(公告)号：US07666882B2

公开(公告)日：2010-02-23

申请号：US10529612

申请日：2003-11-12

Applicant: George Philip Lahm

Inventor： George Philip Lahm

IPC: A61K31/4439 ,  C07D401/04

CPC classification number: C07D401/04 ,  A01N43/56 ,  C07D231/14 ,  C07D401/14

Abstract: This invention provides compounds of Formula I, N-oxides and suitable salts thereof wherein Y and V are each independently N or CR4a; W is N, CH or CR6; and R1 through R6, and n are as defined in the disclosure. This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or an agronomic or nonagronomic suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent, and optionally further comprising an effective amount of at least one additional biologically active compound or agent. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, an N-oxide thereof or an agronomic or nonagronomic suitable salt of the compound or with the composition described herein.

Abstract translation: 本发明提供式I化合物，N-氧化物及其合适的盐，其中Y和V各自独立地为N或CR4a; W是N，CH或CR6; 并且R1至R6和n如本公开中所定义。 本发明还涉及用于控制无脊椎害虫的组合物，其包含生物学有效量的式I化合物，其N-氧化物或化合物的农艺或非农学合适的合适的盐和至少一种选自以下的另外的组分： 表面活性剂，固体稀释剂和液体稀释剂，并且任选地还包含有效量的至少一种另外的生物活性化合物或试剂。 还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物学有效量的式I化合物，其N-氧化物或化合物的农艺或非农学上合适的盐或与本文所述的组合物接触 。

公开(公告)号：US20090133318A1

公开(公告)日：2009-05-28

申请号：US11665442

申请日：2005-11-18

Applicant: George Philip Lahm

Inventor： George Philip Lahm

IPC: A01M1/20 ,  A01N25/06 ,  C07D401/02 ,  A01N43/40 ,  C07D231/12 ,  A01N43/56 ,  C07D239/02 ,  A01N43/54

CPC classification number: C07D231/16 ,  A01N43/56 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  A01N51/00 ,  A01N47/40 ,  A01N2300/00

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein J is a phenyl optionally substituted with one to four substituents independently selected from R5; or J is a heterocyclic ring selected from the group consisting of J-1 to J-8; R4 is C4-C12 alkylcycloalkyl, C5-C12 alkenylcycloalkyl, C5-C12 alkynylcycloalkyl, C4-C12 cycloalkylalkyl, C5-C12 cycloalkylalkenyl, C5-C12 cycloalkylalkynyl, C4-C12 cycloalkenylalkyl or C4-C12 alkylcycloalkenyl; each optionally substituted with one to six substituents selected from CH3 and halogen; and R1a, R1b, R2, R3 and R5 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract translation: 公开了式1的化合物，包括所有几何和立体异构体，N-氧化物及其盐，其中J是任选被一至四个独立地选自R 5的取代基取代的苯基; 或J为选自J-1至J-8的杂环; R4是C4-C12烷基环烷基，C5-C12烯基环烷基，C5-C12炔基环烷基，C4-C12环烷基烷基，C5-C12环烷基烯基，C5-C12环烷基炔基，C4-C12环烯基烷基或C4-C12烷基环烯基; 各自任选被一至六个选自CH 3和卤素的取代基取代; 并且R 1a，R 1b，R 2，R 3和R 5如本公开所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，包括使无脊椎害虫或其环境与生物有效量的本发明化合物或组合物接触。

公开(公告)号：US20080275061A1

公开(公告)日：2008-11-06

申请号：US12141170

申请日：2008-06-18

Applicant: George Philip Lahm ,  Stephen Frederick McCann ,  Kanu Maganbhai Patel ,  Thomas Paul Selby ,  Thomas Martin Stevenson

Inventor： George Philip Lahm ,  Stephen Frederick McCann ,  Kanu Maganbhai Patel ,  Thomas Paul Selby ,  Thomas Martin Stevenson

IPC: A01N43/56 ,  C07D231/14 ,  C07D401/02 ,  C07D403/02 ,  A01N43/90 ,  A01P7/04 ,  A01N43/60

CPC classification number: A01N43/56 ,  A01N43/54 ,  A01N43/58 ,  A01N43/86 ,  C07C251/76 ,  C07D213/77 ,  C07D231/06 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14

Abstract: This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure.This invention further relates to a bezoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.

Abstract translation: 本发明涉及一种控制鳞翅目，同翅目，半翅目，鳞翅目和鞘翅目昆虫害虫的方法，包括使昆虫或其环境与节肢动物学有效量的式I化合物，其N-氧化物或农业上合适的盐接触，其中A 并且B和R 1至R 8如本公开中所定义。 本发明进一步涉及式10的唑嗪酮化合物，其中R 4至R 8如本文所定义，可用于制备式I化合物。

公开(公告)号：US09073910B2

公开(公告)日：2015-07-07

申请号：US13037257

申请日：2011-02-28

Applicant: George Philip Lahm ,  Kanu Maganbhai Patel ,  Thomas Francis Pahutski, Jr. ,  Benjamin Kenneth Smith ,  Jeffrey Keith Long

Inventor： George Philip Lahm ,  Kanu Maganbhai Patel ,  Thomas Francis Pahutski, Jr. ,  Benjamin Kenneth Smith ,  Jeffrey Keith Long

IPC: C07D413/14 ,  A01N43/80 ,  C07D261/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/14

CPC classification number: C07D413/14 ,  A01N43/80 ,  C07D261/04 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/14

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2 and A3 are independently selected from the group consisting of CR3 and N; B1 B2 and B3 are independently selected from the group consisting of CR2 and N; Q is a phenyl ring or a 5- or 6-membered saturated or unsaturated heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, —CN, —NO2, —N(R4)R5, —C(W)N(R4)R5, —C(O)OR5 and R8; or —S(O)2N(R21)R22, —S(O)pR25 or —S(O)(═NR28)R29; and R1, R2, R3, R4, R5, R8, R21, R22, R25, R28, R29; p and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition' of the invention.

Abstract translation: 公开了式1的化合物，包括所有几何和立体异构体，N-氧化物及其盐，其中A1，A2和A3独立地选自CR3和N; B1 B2和B3独立地选自CR2和N; Q是苯环或5或6元饱和或不饱和杂环，每个环任选被一个或多个独立地选自卤素，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6环烷基，C 3 -C 6环烷基， C 1 -C 6卤代烷基，C 1 -C 6烷氧基，C 1 -C 6卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基，C 1 -C 6烷基亚磺酰基，C 1 -C 6卤代烷基亚磺酰基，C 1 -C 6烷基磺酰基， N（R4）R5，-C（W）N（R4）R5，-C（O）OR5和R8; 或-S（O）2 N（R 21）R 22，-S（O）p R 25或-S（O）（= NR 28）R 29; 和R 1，R 2，R 3，R 4，R 5，R 8，R 21，R 22，R 25，R 28，R 29; p和n如本公开中所定义。 还公开了含有式1化合物和控制无脊椎动物害虫的方法的组合物，其包括使无脊椎害虫或其环境与生物有效量的本发明的化合物或组合物接触。