公开(公告)号：US09943597B2

公开(公告)日：2018-04-17

申请号：US13817414

申请日：2011-08-17

申请人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/395 ,  A61K39/40 ,  C07K16/12 ,  A61K39/00

CPC分类号： A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/12

摘要： Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.

公开(公告)号：US20130224216A1

公开(公告)日：2013-08-29

申请号：US13817414

申请日：2011-08-17

申请人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/40

CPC分类号： A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/12

摘要： Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.

摘要翻译： 用于治疗包括肝功能障碍的病症的方法和组合物，例如与脂肪肝相关; 葡萄糖不耐症; 和其他，通过施用包含抗LPS免疫球蛋白的初乳制剂的组合物。

公开(公告)号：US09387222B2

公开(公告)日：2016-07-12

申请号：US12744512

申请日：2008-11-27

申请人： Yaron Ilan ,  Gadi Lalazar ,  Eyal Shteyer ,  Ami Ben-Yaakov ,  Smadar Cohen ,  Tsiona Elkayam

发明人： Yaron Ilan ,  Gadi Lalazar ,  Eyal Shteyer ,  Ami Ben-Yaakov ,  Smadar Cohen ,  Tsiona Elkayam

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K38/02 ,  A61P1/16 ,  A61K31/734 ,  A61K31/738 ,  A61L27/20 ,  A61L31/04

CPC分类号： A61K31/738 ,  A61K31/734 ,  A61L27/20 ,  A61L31/042 ,  A61P1/16 ,  C08L5/04

摘要： The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.

摘要翻译： 本发明涉及在有需要的受试者中治疗肝脏疾病的方法。 更具体地，本发明的方法基于治疗有效量的至少一种生物相容性藻酸盐生物材料，其任何修饰以及它们的任何组合，优选全身施用。 本发明还提供了在患有肝脏障碍的受试者中维持血清白蛋白水平和/或降低血清AST和ALT的方法。 此外，本发明提供了使用本发明描述的藻酸盐生物材料减少患有肝脏疾病的受试者的损伤的肝组织中细胞凋亡和诱导细胞增殖的方法。

公开(公告)号：US20100247652A1

公开(公告)日：2010-09-30

申请号：US12744512

申请日：2008-11-27

申请人： Yaron Ilan ,  Gadi Lalazar ,  Eyal Shteyer ,  Ami Ben-Yaakov ,  Smadar Cohen ,  Tsiona Elkayam

发明人： Yaron Ilan ,  Gadi Lalazar ,  Eyal Shteyer ,  Ami Ben-Yaakov ,  Smadar Cohen ,  Tsiona Elkayam

IPC分类号： A61K31/734 ,  A61K9/10 ,  A61K9/00 ,  A61K38/02 ,  A61P1/16

CPC分类号： A61K31/738 ,  A61K31/734 ,  A61L27/20 ,  A61L31/042 ,  A61P1/16 ,  C08L5/04

摘要： The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.

摘要翻译： 本发明涉及在有需要的受试者中治疗肝脏疾病的方法。 更具体地，本发明的方法基于治疗有效量的至少一种生物相容性藻酸盐生物材料，其任何修饰以及它们的任何组合，优选全身施用。 本发明还提供了在患有肝脏障碍的受试者中维持血清白蛋白水平和/或降低血清AST和ALT的方法。 此外，本发明提供了使用本发明描述的藻酸盐生物材料减少患有肝脏疾病的受试者的损伤的肝组织中细胞凋亡和诱导细胞增殖的方法。

公开(公告)号：US20070184058A1

公开(公告)日：2007-08-09

申请号：US11591153

申请日：2006-11-01

申请人： Yaron Ilan ,  Gadi Lalazar

发明人： Yaron Ilan ,  Gadi Lalazar

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/38

CPC分类号： A61K31/7032 ,  A61K31/739 ,  A61K38/1709 ,  A61K2300/00

摘要： This invention relates to the use of naturally occurring mammalian intermediary metabolites, Tcell ligands or Tcell receptor ligands, preferably glycosylceramides, for the treatment or prevention of immune mediated or immune related diseases or disorders. Specifically, the present invention provides compositions and methods for the treatment or prevention of pulmonary, respiratory or airway diseases or disorders such as asthma.

摘要翻译： 本发明涉及天然存在的哺乳动物中间代谢物，T细胞配体或T细胞受体配体，优选糖基神经酰胺，用于治疗或预防免疫介导或免疫相关疾病或病症的用途。 具体地，本发明提供了用于治疗或预防肺，呼吸道或气道疾病或病症如哮喘的组合物和方法。

公开(公告)号：US10117930B2

公开(公告)日：2018-11-06

申请号：US13265252

申请日：2010-04-27

申请人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/40 ,  A61K39/395 ,  C07K16/04 ,  C07K16/12 ,  C07K16/26 ,  A61K39/00

摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.

公开(公告)号：US20110200610A1

公开(公告)日：2011-08-18

申请号：US12879129

申请日：2010-09-10

申请人： Yaron ILAN ,  Gadi LALAZAR ,  Ami Ben YA'ACOV ,  Tomer ADAR

发明人： Yaron ILAN ,  Gadi LALAZAR ,  Ami Ben YA'ACOV ,  Tomer ADAR

IPC分类号： A61K39/395 ,  A61P3/10 ,  A61P1/16 ,  C07K16/26

CPC分类号： C07K16/26 ,  A61K39/395 ,  A61K2039/55588 ,  A61K2039/57 ,  A61K2300/00

摘要： The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner.

摘要翻译： 本发明涉及免疫调节组合物，其包含哺乳动物初乳衍生的免疫球蛋白制备物和任选的另外的初乳，乳或乳制品成分和用于治疗免疫相关病症的任何佐剂。 更具体地，本发明提供了包含用于治疗代谢综合征的初乳衍生的抗胰岛素免疫球蛋白制剂的组合物。 本发明还提供免疫调节组合物在疾病 - 抗原特异性或非特异性方式中的主动或被动免疫的方法和用途。

公开(公告)号：US20100249048A1

公开(公告)日：2010-09-30

申请号：US12746430

申请日：2008-12-07

申请人： Yaron Ilan ,  Haim Lotan ,  Mony Shuvy ,  Gadi Lalazar

发明人： Yaron Ilan ,  Haim Lotan ,  Mony Shuvy ,  Gadi Lalazar

IPC分类号： A61K31/7028 ,  A61P13/12 ,  C12N5/02

CPC分类号： A61K31/7028 ,  A61K31/662 ,  A61K31/7032 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a composition comprising a combination of at least one natural or synthetic β-glycolipid, a mixture of at least two β-glycolipids, a substance which increases the intracellular, extracellular or serum level of a naturally occurring β-glycolipid, or any combination or mixture thereof and at least one phosphate inhibitor or any compound that alters the phosphate binding or transporting into or out of any cell or any membrane or any combination thereof. The combined composition of the invention may be particularly used for treating calcification related degenerative disorders, specifically, vascular and valvular disorders. The invention further provides kits methods and uses thereof for treatment of calcification related disorders.

摘要翻译： 本发明涉及一种组合物，其包含至少一种天然或合成的糖脂，至少两种和乙二醇的混合物，一种增加天然存在的蛋白质的细胞内，细胞外或血清水平的物质的组合。 - 糖脂或其任何组合或混合物，以及至少一种磷酸盐抑制剂或改变磷酸盐结合或运输到或流出任何细胞或任何膜的任何化合物或其任何组合。 本发明的组合组合物可特别用于治疗与钙化相关的退行性疾病，特别是血管和瓣膜疾病。 本发明还提供了用于治疗钙化相关疾病的试剂盒方法及其用途。