公开(公告)号：US20060275851A1

公开(公告)日：2006-12-07

申请号：US11189038

申请日：2005-07-26

申请人： Michael Emmert-Buck ,  Gallya Gannot

发明人： Michael Emmert-Buck ,  Gallya Gannot

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/54366 ,  G01N33/564

摘要： A method and composition for the identification of biomolecule in a sample are disclosed. The method comprises obtaining a coated capture membrane stack comprising a plurality of capture membranes with each capture membrane coated with a different peptide. The membrane stack is exposed to a sample, and, after a given amount of time for the sample to permeate the membrane stack, the membrane stack is removed from the sample carrier and the capture membrane to which the biomolecule adheres is identified.

公开(公告)号：US20120002199A1

公开(公告)日：2012-01-05

申请号：US13143335

申请日：2010-01-05

申请人： Moshe Ben-David ,  Tomer Eruv ,  Gallya Gannot

发明人： Moshe Ben-David ,  Tomer Eruv ,  Gallya Gannot

IPC分类号： G01J3/28 ,  G01N21/01

CPC分类号： G01N21/031 ,  G01N21/33 ,  G01N21/3581 ,  G01N21/359 ,  G01N2015/0088 ,  G01N2015/0693

摘要： The present invention provides an optical unit (320) adapted to accommodate a sample and to enable optical detection of infection within said sample; said optical unit comprising a body (100); said body is characterized by a distal end and a proximal end interconnected via a main longitudinal axis; said body (100) comprising at least one mirror (50) coupled to said distal end; wherein said mirror (50) having a proximal and distal surfaces; said proximal surface faces said mask; said proximal surface is adapted to accommodate said sample.

摘要翻译： 本发明提供了一种光学单元（320），其适于容纳样品并且能够光学检测所述样品内的感染; 所述光学单元包括主体（100）; 所述主体的特征在于远端和通过主纵向轴线相互连接的近端; 所述主体（100）包括联接到所述远端的至少一个反射镜（50） 其中所述反射镜（50）具有近端和远端表面; 所述近端表面面对所述掩模; 所述近端表面适于容纳所述样品。

公开(公告)号：US20090215073A1

公开(公告)日：2009-08-27

申请号：US12289736

申请日：2008-11-03

申请人： Michael Emmert-Buck ,  Gallya Gannot

发明人： Michael Emmert-Buck ,  Gallya Gannot

IPC分类号： G01N33/53

CPC分类号： G01N33/54366 ,  G01N33/564

摘要： A method and composition for the identification of biomolecule in a sample are disclosed. The method comprises obtaining a coated capture membrane stack comprising a plurality of capture membranes with each capture membrane coated with a different peptide. The membrane stack is exposed to a sample, and, after a given amount of time for the sample to permeate the membrane stack, the membrane stack is removed from the sample carrier and the capture membrane to which the biomolecule adheres is identified.

摘要翻译： 公开了用于鉴定样品中生物分子的方法和组合物。 该方法包括获得包含多个捕获膜的包被的捕获膜堆叠，每个捕获膜涂覆有不同的肽。 将膜堆叠暴露于样品，并且在给定时间用于样品渗透膜堆叠之后，将膜堆叠从样品载体上移除，并鉴定生物分子附着的捕获膜。

公开(公告)号：US09102975B2

公开(公告)日：2015-08-11

申请号：US12594780

申请日：2008-04-06

申请人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv

发明人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv

IPC分类号： G01N33/48 ,  G01N31/00 ,  G01N33/50 ,  C12Q1/04 ,  G06F19/26 ,  G06F19/12 ,  G06F19/24 ,  G01N21/31

CPC分类号： C12Q1/04 ,  G01N21/31 ,  G06F19/12 ,  G06F19/24 ,  G06F19/26

摘要： The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume.

摘要翻译： 本发明提供了一种用于在未培养的样品中检测和/或鉴定特定细菌的方法。 该方法包括以下步骤：特别是（a）获得所述未培养样品的吸收光谱（AS）; （b）获取所述特定细菌的n维体积边界; （c）数据处理表示AS; 以及（d）如果所述m1统计相关和/或所述m个特征在所述n维体积内，则检测和/或识别所述特定细菌。

公开(公告)号：US20110184654A1

公开(公告)日：2011-07-28

申请号：US13062790

申请日：2009-09-16

申请人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv ,  Zvi Markowitz

发明人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv ,  Zvi Markowitz

IPC分类号： G06F19/00

CPC分类号： G06K9/00496

摘要： This disclosure provides a method for detecting and/or identifying uncultured bacteria. The sample is an aerosol sample selected from a group consisting of cough, sneeze, saliva, mucus, bile, urine, vaginal secretions, middle ear aspirate, pus, pleural effusions, synovial fluid, abscesses, cavity swabs, serum, blood and spinal fluid. The method comprises obtaining absorption spectra (AS) of the sample, extracting and processing the acquired data, thereby detecting and/or identifying the bacteria.

摘要翻译： 本公开提供了用于检测和/或识别未培养的细菌的方法。 样品是选自咳嗽，打喷嚏，唾液，粘液，胆汁，尿液，阴道分泌物，中耳抽吸物，脓液，胸腔积液，滑液，脓肿，腔拭子，血清，血液和脊髓液的气溶胶样品 。 该方法包括获得样品的吸收光谱（AS），提取和处理所获取的数据，从而检测和/或识别细菌。

公开(公告)号：US20110178721A1

公开(公告)日：2011-07-21

申请号：US13120343

申请日：2009-10-11

申请人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv ,  Zvi Markowitz

发明人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv ,  Zvi Markowitz

IPC分类号： G06F19/00

CPC分类号： G06K9/00496

摘要： The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample, comprising steps of: a. obtaining an absorption spectrum (AS) of said uncultured sample; b. acquiring the n dimensional volume boundaries for said specific bacteria; c. data processing said AS; i. noise reducing; ii. extracting m features from said entire AS; iii. dividing said AS into several segments according to said m features; iv. calculating m1 features of each of said segment; and, d. detecting and/or identifying said specific bacteria if said m1 features and/or said m features are within said n dimensional volume; wherein said bacteria is a antibiotics resistance bacteria.

摘要翻译： 本发明提供了用于检测和/或鉴定未培养样品中的特定细菌的方法，包括以下步骤：a。 获得所述未培养样品的吸收光谱（AS）; b。 获取所述特定细菌的n维体积边界; C。 数据处理表示AS; 一世。 降噪; ii。 从整个AS中提取m个特征; iii。 根据所述m个特征将所述AS划分成若干段; iv。 计算每个所述段的m1特征; 和，d。 如果所述m1特征和/或所述m个特征在所述n维体积内，则检测和/或识别所述特定细菌; 其中所述细菌是抗生素抗性细菌。

公开(公告)号：US20100099139A1

公开(公告)日：2010-04-22

申请号：US12594780

申请日：2008-04-06

申请人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv

发明人： Moshe Ben-David ,  Gallya Gannot ,  Tomer Eruv

IPC分类号： C12Q1/14 ,  C12Q1/04 ,  C12M1/34

CPC分类号： C12Q1/04 ,  G01N21/31 ,  G06F19/12 ,  G06F19/24 ,  G06F19/26

摘要： The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume.

摘要翻译： 本发明提供了一种用于在未培养的样品中检测和/或鉴定特定细菌的方法。 该方法包括以下步骤：特别是（a）获得所述未培养样品的吸收光谱（AS）; （b）获取所述特定细菌的n维体积边界; （c）数据处理表示AS; 以及（d）如果所述m1统计相关和/或所述m个特征在所述n维体积内，则检测和/或识别所述特定细菌。