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    Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
    1.
    发明授权
    Antidepressant piperidine derivatives of heterocycle-fused benzodioxans 失效
    杂环稠合苯并二恶烷的抗抑郁药哌啶衍生物

    公开(公告)号：US06939877B2

    公开(公告)日：2005-09-06

    申请号：US10659160

    申请日：2003-09-10

    申请人： Michael Bryon Webb ,  Gary Paul Stack ,  Magda Asselin ,  Deborah A. Evrard

    发明人： Michael Bryon Webb ,  Gary Paul Stack ,  Magda Asselin ,  Deborah A. Evrard

    IPC分类号： C07D491/04 ,  C07D498/04 ,  A61K31/4741 ,  C07D491/02

    CPC分类号： C07D491/04

    摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

    摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁障碍，儿童抑郁症和心境恶化），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为经前期综合征） 注意力缺陷障碍（伴有或不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。

    Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans
    2.
    发明申请
    Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans 审中-公开
    抗菌抑制剂哌啶衍生物的杂环稠合苯并二恶烷

    公开(公告)号：US20090042895A1

    公开(公告)日：2009-02-12

    申请号：US12254118

    申请日：2008-10-20

    申请人： Michael Byron Webb ,  Gary Paul Stack ,  Magda Asselin ,  Deborah A. Evrard

    发明人： Michael Byron Webb ,  Gary Paul Stack ,  Magda Asselin ,  Deborah A. Evrard

    IPC分类号： A61K31/4985 ,  C07D491/056 ,  A61K31/436 ,  C07D498/04 ,  A61K31/454 ,  A61P25/24

    CPC分类号： C07D491/04

    摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

    摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁症，儿童抑郁症和抑郁症），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为月经前综合征 ），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。

    Antidepressant piperidine derivatives of heterocyclefused benzodioxans
    7.
    发明授权
    Antidepressant piperidine derivatives of heterocyclefused benzodioxans 失效
    杂环烯基苯并二恶烷的抗抑郁药哌啶衍生物

    公开(公告)号：US07479500B2

    公开(公告)日：2009-01-20

    申请号：US11142787

    申请日：2005-06-01

    申请人： Michael Byron Webb ,  Gary Paul Stack ,  Magda Asselin ,  Deborah Ann Evrard

    发明人： Michael Byron Webb ,  Gary Paul Stack ,  Magda Asselin ,  Deborah Ann Evrard

    IPC分类号： A61K31/44 ,  C07D413/14

    CPC分类号： C07D491/04

    摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

    摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于严重抑郁症，儿童抑郁症和抑郁症），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为月经前综合征 ），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。

    Method of treating bone loss by stimulation of calcitonin
    9.
    发明授权
    Method of treating bone loss by stimulation of calcitonin 失效
    通过刺激降钙素治疗骨质流失的方法

    公开(公告)号：US06221874B1

    公开(公告)日：2001-04-24

    申请号：US09303972

    申请日：1999-05-03

    申请人： Adam Matthew Gilbert ,  Gerardo Francisco ,  Magda Asselin

    发明人： Adam Matthew Gilbert ,  Gerardo Francisco ,  Magda Asselin

    IPC分类号： C07D47306

    CPC分类号： C07D473/06 ,  A61K31/522

    摘要： Compounds of the formula R1 and R2 are independently alkyl of 1 to 6 carbon atoms, allyl, or substituted allyl of 3 to 6 carbon atoms; R3 is hydrogen, alkyl of 1 to 6 carbon atoms, or cycloalkyl of 3 to 10 carbon atoms; and R4 is phenyl or naphthyl substituted with alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms or NR5R6; substituted or unsubstituted phenylalkyl wherein the alkyl group contains 1 to 6 carbon atoms; substituted or unsubstituted 5 to 10 membered heteroaryl having 1 to 3 heteroatoms selected from N, S and O; substituted or unsubstituted cycloalkyl of 3 to 10 carbon atoms; or substituted or unsubstituted cycloalkylalkyl of 4 to 10 carbon atoms; provided that phenyl or naphthyl is substituted with NR5R6 when R1 and R2 is alkyl, are useful in the treatment of various disorders associated bone loss by increased transcription and elevation of plasma calcitonin levels. Such disorders include, but are not limited to: Paget's Disease, post menopausal osteoporosis, senile osteoporosis, and glucocorticoid-induced osteoporosis.

    摘要翻译： 式R1和R2的化合物独立地为1至6个碳原子的烷基，烯丙基或3至6个碳原子的取代的烯丙基; R3为氢，1〜6个碳原子的烷基或3〜10个碳原子的环烷基; R4为苯基或被1-6个碳原子的烷基取代的萘基，具有1-6个碳原子的烷氧基或NR5R6; 取代或未取代的苯基烷基，其中烷基含有1至6个碳原子; 取代或未取代的具有1至3个选自N，S和O的杂原子的5至10元杂芳基; 3至10个碳原子的取代或未取代的环烷基; 或取代或未取代的4-10个碳原子的环烷基烷基; 条件是当R 1和R 2为烷基时苯基或萘基被NR 5 R 6取代，可用于通过增加转录和升高血浆降钙素水平来治疗与骨丢失相关的各种疾病。 这种病症包括但不限于：佩吉特氏病，绝经后骨质疏松症，老年性骨质疏松症和糖皮质激素诱导的骨质疏松症。