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公开(公告)号：US5783403A
公开(公告)日：1998-07-21
申请号：US195487
申请日：1994-02-14
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , C12P21/08
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
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2.发明授权Binding proteins to malignant cell type markers of the interior nuclear matrix 失效将蛋白结合到内部核基质的恶性细胞型标记物中
公开(公告)号：US5780596A
公开(公告)日：1998-07-14
申请号：US467781
申请日：1995-06-06
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , A61K39/395
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US5686562A
公开(公告)日：1997-11-11
申请号：US466390
申请日：1995-06-06
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , A61K38/16 , C07K5/00 , C07K7/00
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US5882876A
公开(公告)日：1999-03-16
申请号：US483924
申请日：1995-06-07
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/48 , G01N33/53
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US5698439A
公开(公告)日：1997-12-16
申请号：US470950
申请日：1995-06-06
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , C12N1/20
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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