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    ELECTROCHEMICAL 18F EXTRACTION, CONCENTRATION AND REFORMULATION METHOD FOR RAIOLABELING
    3.
    发明申请
    ELECTROCHEMICAL 18F EXTRACTION, CONCENTRATION AND REFORMULATION METHOD FOR RAIOLABELING 审中-公开
    电化学18F萃取，浓缩和改性方法

    公开(公告)号：US20100069600A1

    公开(公告)日：2010-03-18

    申请号：US12439943

    申请日：2007-09-05

    申请人： Jean-Luc Morelle ,  Samuel Voccia ,  Gauthier Philippart

    发明人： Jean-Luc Morelle ,  Samuel Voccia ,  Gauthier Philippart

    IPC分类号： C08G63/78 ,  B01D59/40 ,  G21G4/00

    CPC分类号： G21G4/08 ,  G21G2001/0015 ,  G21H5/02

    摘要： A method to extract out of water, concentrate and reformulate [18F] fluorides includes passing a dilute aqueous [18F] fluoride solution entering by an inlet (1) in a cavity (6) embodying an electrochemical cell with at least two electrodes (3, 4, 5), flowing in the cavity (6) and coming out of the cavity (6) by an outlet (2), an external voltage being applied to the electrodes. One electrode (4) is used as an extraction electrode, another one (3) is used for polarizing the solution, and configured so that at least the extraction electrode (4), either used as a cathode or as an anode, is in contact with and polarizes a large specific surface area conducting material (7), contained in the cavity (6). The extracted ions are released from the surface of the large specific surface area conducting material (7) by turning off the applied external voltage. During its passage in the cavity (6), the dilute aqueous [18F] fluoride solution entirely crosses and internally soaks the large specific surface area conducting material (7).

    摘要翻译： 提取出水，浓缩和重整[18 F]氟化物的方法包括使通过入口（1）进入的稀释的[18 F]氟化物水溶液在具有至少两个电极（3， 在腔（6）中流动并通过出口（2）从空腔（6）流出的外部电压施加到电极上。 使用一个电极（4）作为引出电极，另一个电极（3）用于使溶液极化，并且构造成使得至少用作阴极或阳极的引出电极（4）接触 使包含在空腔（6）中的大比表面积导电材料（7）极化。 通过关闭施加的外部电压，提取的离子从大比表面积导电材料（7）的表面释放。 在空腔（6）中通过期间，稀的氟化水溶液完全穿过并内部浸泡大比表面积导电材料（7）。

    Dispenser cartridge for radiopharmaceuticals
    5.
    发明授权
    Dispenser cartridge for radiopharmaceuticals 有权
    用于放射性药物的分配器盒

    公开(公告)号：US08348903B2

    公开(公告)日：2013-01-08

    申请号：US11545895

    申请日：2006-10-11

    申请人： Frédéric Baplue ,  Philippe Bekaert ,  Jean-Luc Morelle ,  Gauthier Philippart

    发明人： Frédéric Baplue ,  Philippe Bekaert ,  Jean-Luc Morelle ,  Gauthier Philippart

    IPC分类号： A61M5/32 ,  A61M5/00

    CPC分类号： A61N5/1007 ,  A61M5/1785 ,  A61M5/2466 ,  A61M5/31515 ,  A61M5/346 ,  G21F5/015 ,  G21Y2002/205 ,  G21Y2004/30

    摘要： A cartridge for radiopharmaceutical packaging includes a low UV-absorbing plastic barrel, closed at one end by a cap and at the other by a piston. A shoulder cooperates with the barrel in a double-level snap-on system with a cavity cooperating with an injection fitting sleeve to make a seal. At a first end the cap has a peel-off porous liner covering the cavity. Radial fins protrude inside the cavity, for screwing the injection fitting and second radial fins protrude outside of the cap to fix to a cartridge protection shield. A second end minimizes a shadow area of UV flash lamp sterilization and ensures clearance for inserting an injection spike. The second end has a reduced wall thickness pierced by the spike during set up for dispensing of the pharmaceutical. An external cylindrical zone at the second end ensures leak tightness between the cap and the barrel.

    摘要翻译： 用于放射性药物包装的药筒包括低吸收UV的塑料桶，其一端由帽封闭，另一端由活塞封闭。 一个肩部与一个双层卡扣系统配合，其中一个空腔与一个注射套管配合以形成一个密封。 在第一端，盖具有覆盖空腔的剥离多孔衬里。 径向翼片突出在空腔内部，用于拧入注射配件，第二径向翅片突出到盖的外侧，以固定到药筒保护罩。 第二端可最大限度地减少UV闪光灯灭菌的阴影区域，并确保插入注射尖峰的间隙。 第二端在用于分配药物的设置期间具有由尖峰刺穿的壁厚减小。 在第二端的外部圆柱形区域确保了盖和桶之间的密封性。

    Dispenser cartridge for radiopharmaceuticals
    7.
    发明申请
    Dispenser cartridge for radiopharmaceuticals 有权
    用于放射性药物的分配器盒

    公开(公告)号：US20080171999A1

    公开(公告)日：2008-07-17

    申请号：US11545895

    申请日：2006-10-11

    申请人： Frederic Baplue ,  Philippe Bekaert ,  Jean-Luc Morelle ,  Gauthier Philippart

    发明人： Frederic Baplue ,  Philippe Bekaert ,  Jean-Luc Morelle ,  Gauthier Philippart

    IPC分类号： A61M5/32

    CPC分类号： A61N5/1007 ,  A61M5/1785 ,  A61M5/2466 ,  A61M5/31515 ,  A61M5/346 ,  G21F5/015 ,  G21Y2002/205 ,  G21Y2004/30

    摘要： An improved cartridge for the packaging of a pharmaceutical, and preferably a radiopharmaceutical, comprising a low UV-absorbing plastic barrel, closed at one end by a cap and at the other end by a piston. Said cap is provided at least partly with: a shoulder cooperating with the barrel in a double-level snap-on system; a cavity to cooperate with an elastomeric protection sleeve of an injection means fitting, to make a seal, said cap being terminated at a first end by a peel-off porous liner covering said cavity; a first plurality of radial fins protruding inside said cavity, for screwing the injection means fitting and with a second plurality of radial fins protruding on the outside of the cap to ensure fixation of the cap into a cartridge protection shield; a second end opposite to the first end, shaped so that to minimize a shadow area in the case of UV flash lamp sterilization and to ensure sufficient clearance for inserting a spike of the injection means, said second end having a reduced wall thickness for acting as a septum intended to be pierced by said spike at the time of setting up for dispensing the pharmaceutical to a patient; an external cylindrical zone at this second end to ensure leak tightness between the cap and the barrel.

    摘要翻译： 用于包装药物，优选放射性药物的改进的药筒，包括低吸收UV的塑料桶，其一端由帽封闭，另一端由活塞封闭。 所述盖至少部分地设置有：在双层卡扣系统中与所述筒配合的肩部; 与注射装置的弹性体保护套配合的空腔，以形成密封，所述盖在第一端处被覆盖所述空腔的剥离多孔衬里终止; 突出在所述空腔内的第一多个径向翅片，用于旋转注射装置配合件，以及突出在盖子的外侧上的第二多个径向翅片，以确保盖子固定到药筒保护罩中; 与第一端相对的第二端被成形为使得在UV闪光灯灭菌的情况下最小化阴影区域并且确保用于插入注射装置的尖峰的足够的间隙，所述第二端具有减小的壁厚，用作 在设置用于将药物分配给患者时，旨在被所述尖刺刺穿的隔膜; 在该第二端处的外部圆柱形区域以确保盖和桶之间的密封性。