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    IMPLANTABLE CARDIAC STIMULATION DEVICE, SYSTEM AND METHOD WHICH PROVIDES AN ELECTROGRAM SIGNAL FACILITATING MEASUREMENT OF SLOW-CHANGING ELECTROGRAM FEATURES
    1.
    发明申请
    IMPLANTABLE CARDIAC STIMULATION DEVICE, SYSTEM AND METHOD WHICH PROVIDES AN ELECTROGRAM SIGNAL FACILITATING MEASUREMENT OF SLOW-CHANGING ELECTROGRAM FEATURES 有权
    可植入心脏刺激装置，系统和方法提供电子信号促进慢变化电子特征的测量

    公开(公告)号：US20080033499A1

    公开(公告)日：2008-02-07

    申请号：US11871873

    申请日：2007-10-12

    申请人： Peter Boileau ,  Gene Bornzin ,  Jong Gill

    发明人： Peter Boileau ,  Gene Bornzin ,  Jong Gill

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3702 ,  A61B5/04018 ,  A61B5/042 ,  A61B5/0452 ,  A61N1/368

    摘要： An implantable cardiac system including an implantable cardiac stimulation device provides a heart activity signal of a heart facilitating measurement of slowly changing electrogram features. The system comprises at least one implantable electrode arrangement that senses cardiac electrical activity and provides an intracardiac electrogram signal, a first high pass filter that filters the electrogram and an equalizer that filters the filtered electrogram signal. The equalizer has a transfer function that is non-decreasing for frequencies up to a lower frequency breakpoint that is less than the upper frequency breakpoint, decreasing for frequencies between the lower frequency breakpoint and the upper frequency breakpoint, and generally flat for frequencies above the upper frequency breakpoint through a bandpass region of interest.

    摘要翻译： 包括可植入心脏刺激装置的可植入心脏系统提供心脏的心脏活动信号，便于测量缓慢变化的电描绘图特征。 该系统包括感测心脏电活动并提供心内电描记图信号的至少一个可植入电极装置，对电描记图进行滤波的第一高通滤波器和对经滤波的电描记图信号进行滤波的均衡器。 均衡器具有对于低于较高频率断点的频率的频率不降低的传递函数，对于较低频率断点和较高频率断点之间的频率而言降低，并且对于高于上限频率的频率，通常平坦 频率断点通过感兴趣的带通区域。

    Methods for ventricular pacing
    2.
    发明申请
    Methods for ventricular pacing 审中-公开
    心室起搏方法

    公开(公告)号：US20050125041A1

    公开(公告)日：2005-06-09

    申请号：US10703070

    申请日：2003-11-05

    申请人： Xiaoyi Min ,  Gene Bornzin

    发明人： Xiaoyi Min ,  Gene Bornzin

    IPC分类号： A61N1/362 ,  A61N1/368

    CPC分类号： A61N1/3627 ,  A61N1/368

    摘要： An exemplary method includes determining an atrial to ventricular activation time for a right ventricle; determining an atrial to ventricular activation time for a left ventricle; and determining a pacing sequence that paces the right ventricle prior to activation of the left ventricle if the time for the right ventricle exceeds the time for the left ventricle or that paces the left ventricle prior to activation of the right ventricle if the time for the left ventricle exceeds the time for the right ventricle, wherein, in the pacing sequence, pacing of the prior, paced ventricle occurs at a time based at least in part on a difference between the time for the right ventricle and the time for the left ventricle and an atrio-ventricular delay limit. Various other exemplary methods, devices and/or systems are also disclosed.

    摘要翻译： 示例性方法包括确定右心室的心室至心室激活时间; 确定左心室的心室至心室激活时间; 并且如果右心室的时间超过左心室的时间或在右心室的激活之前步行左心室，则确定在左心室激活之前步行右心室的起搏序列，如果左侧时间 心室超过右心室的时间，其中，在起搏序列中，先前起搏的心室的起搏至少部分地基于右心室的时间与左心室的时间之间的差异发生，以及 房室延迟限制。 还公开了各种其它示例性方法，装置和/或系统。

    Lead body construction
    3.
    发明申请
    Lead body construction 审中-公开
    铅体结构

    公开(公告)号：US20050080471A1

    公开(公告)日：2005-04-14

    申请号：US10652996

    申请日：2003-08-28

    申请人： Yougandh Chitre ,  Gene Bornzin ,  Sheldon Williams

    发明人： Yougandh Chitre ,  Gene Bornzin ,  Sheldon Williams

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056

    摘要： An implantable cardiac stimulation lead system for use with a stimulation device includes a lead body preferably having an outer diameter of less than 4 French and formed of a biocompatible material having a Young's modulus of at least 20,000 pounds per square inch. In the lead body, an inner insulator is composed of a suitable polymer such as PTFE or ETFE with an outer peripheral surface formed with a helical groove containing a conductor extending between a proximal connector and a distal tip electrode, and an outer insulator composed of polyurethane or silicone rubber or a combination thereof is positioned around the inner insulator. The lead system may be formed with a lumen for receiving a guidewire longitudinally through the lead body. A pair of insulated conductors may be received in the helical groove, one extending to the distal tip electrode, the other extending to a ring electrode proximally spaced from the distal tip electrode.

    摘要翻译： 用于刺激装置的可植入心脏刺激引导系统包括优选具有小于4 French的外径的引线体，并且由具有至少20,000磅/平方英寸的杨氏模量的生物相容性材料形成。 在引线体中，内绝缘体由诸如PTFE或ETFE的合适的聚合物构成，外周表面形成有包含在近端连接器和远端末端电极之间延伸的导体的螺旋槽，以及由聚氨酯 或硅橡胶或其组合位于内绝缘体周围。 引导系统可以形成有用于纵向地通过引线主体接收导丝的内腔。 一对绝缘导体可以容纳在螺旋槽中，一个延伸到远端尖端电极，另一对延伸到与远侧末端电极间隔开的环状电极。

    Collecting and analyzing sensed information as a trend of heart failure progression or regression
    4.
    发明申请
    Collecting and analyzing sensed information as a trend of heart failure progression or regression 有权
    收集和分析感觉信息作为心力衰竭进展或回归的趋势

    公开(公告)号：US20050277992A1

    公开(公告)日：2005-12-15

    申请号：US10866422

    申请日：2004-06-10

    申请人： Steve Koh ,  Euljoon Park ,  Gene Bornzin

    发明人： Steve Koh ,  Euljoon Park ,  Gene Bornzin

    IPC分类号： A61N1/362 ,  A61B5/0402

    CPC分类号： A61N1/3627 ,  A61B5/0245 ,  A61B5/4035

    摘要： An exemplary method includes selecting a cross-correlation frequency having an associated cross-correlation period, detecting and binning a heart rate in a heart rate bin, detecting and binning an activity state in an activity state bin, repeating the detecting and binning a heart rate and the detecting and binning an activity state during a cross-correlation period, and summing the products a bin count of the heart rate bins and a bin count of the activity state bins to provide a cross-correlation index for the cross-correlation period. Other exemplary algorithms, methods, devices, systems, etc., are also disclosed.

    摘要翻译： 一种示例性方法包括选择具有相关联的相关周期的互相关频率，检测和归纳心率仓中的心率，检测和归纳活动状态仓中的活动状态，重复检测和归纳心率 以及在互相关时段期间检测和归纳活动状态，并且将乘积与心率仓的仓计数和活动状态仓的箱数相加，以提供互相关周期的互相关指数。 还公开了其它示例性算法，方法，设备，系统等。

    System and method for predicting a heart condition based on impedance values using an implantable medical device
    5.
    发明申请
    System and method for predicting a heart condition based on impedance values using an implantable medical device 有权
    基于使用可植入医疗装置的阻抗值来预测心脏病的系统和方法

    公开(公告)号：US20050216067A1

    公开(公告)日：2005-09-29

    申请号：US11014276

    申请日：2004-12-15

    申请人： Xiaoyi Min ,  Gene Bornzin ,  Euljoon Park

    发明人： Xiaoyi Min ,  Gene Bornzin ,  Euljoon Park

    IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/37

    CPC分类号： A61N1/36521 ,  A61B5/0538 ,  A61N1/3627 ,  A61N1/371

    摘要： Techniques are provided for predicting the onset of a heart condition within a patient based on impedance measurements. Briefly, overloads in fluid levels in the thorax and in ventricular myocardial mass within the patient are detected based on impedance signals sensed using implanted electrodes. The onset of certain heart conditions is then predicted based on the overloads. For example, pulmonary edema arising due to diastolic heart failure is predicted based on the detection of on-going overloads in both fluid levels and ventricular mass. Ventricular hypertrophy is detected based on an on-going ventricular mass overload without a sustained fluid overload. Various other heart conditions may also be predicted based on specific combinations of recent or on-going overloads. Evoked response is exploited to corroborate the predictions. Appropriate warning signals are generated and preemptive therapy is initiated.

    摘要翻译： 提供了基于阻抗测量来预测患者心脏病状发作的技术。 简单地说，基于使用植入电极感测到的阻抗信号来检测患者胸部液位水平和心室心肌质量的过载。 然后基于过载来预测某些心脏状况的发作。 例如，由于舒张性心力衰竭引起的肺水肿基于检测流体水平和心室质量中的持续过载而被预测。 基于正在进行的心室质量超载而无持续的流体超载检测出心室肥大。 还可以基于最近或正在进行的过载的特定组合来预测各种其他心脏状况。 被诱发的反应被利用来证实预测。 产生适当的警告信号并开始抢先治疗。

    Statistical analysis for implantable cardiac devices
    9.
    发明申请
    Statistical analysis for implantable cardiac devices 审中-公开
    可植入心脏装置的统计分析

    公开(公告)号：US20050059897A1

    公开(公告)日：2005-03-17

    申请号：US10665317

    申请日：2003-09-17

    申请人： Jeffery Snell ,  Gene Bornzin

    发明人： Jeffery Snell ,  Gene Bornzin

    IPC分类号： A61B5/04 ,  A61N1/37 ,  A61B5/0402

    CPC分类号： A61B5/04012 ,  A61N1/371

    摘要： Exemplary methods and devices for analyzing intracardiac electrocardiograms (IEGMs) using statistical analysis (e.g., histograms, etc.), ensemble averaging and/or an ensemble average. Various methods and/or devices are suitable for use with atrial and/or ventricular pacing therapies. Other methods, devices and/or systems are also disclosed.

    摘要翻译： 使用统计分析（例如，直方图等），整体平均和/或整体平均来分析心内心电图（IEGM）的示例性方法和装置。 各种方法和/或装置适用于心房和/或心室起搏疗法。 还公开了其它方法，装置和/或系统。

    SELF-ANCHORING CORONARY SINUS LEAD
    10.
    发明申请
    SELF-ANCHORING CORONARY SINUS LEAD 审中-公开
    自动锚固冠军

    公开(公告)号：US20080065186A1

    公开(公告)日：2008-03-13

    申请号：US11936719

    申请日：2007-11-07

    申请人： Anne Pianca ,  Kevin Morgan ,  Gene Bornzin ,  Joseph Florio ,  David Vachon

    发明人： Anne Pianca ,  Kevin Morgan ,  Gene Bornzin ,  Joseph Florio ,  David Vachon

    IPC分类号： A61N1/05

    CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N2001/0578 ,  A61N2001/0585

    摘要： An implantable cardiac lead system suitable for placement in the coronary sinus region of the heart. The lead system comprises a lead having two or more non-helical bends in its distal portion. The two or more non-helical bends cooperate to prevent the lead from dislodgment or displacement inside the coronary sinus. The lead system may further comprise a stylet suitable for steering the lead into at least one of the coronary sinus vein, great cardiac vein, left marginal vein, left posterior ventricular vein, and small cardiac vein. The stylet is tapered in its distal portion to provide enhanced maneuverability and steerability inside the coronary sinus region. The lead system may also comprise an introducer which aids in introducing the lead into the heart.

    摘要翻译： 适用于放置在心脏冠状静脉窦区域的可植入心脏引导系统。 引导系统包括在其远端部分中具有两个或多个非螺旋形弯曲部的引线。 两个或更多个非螺旋形弯曲合作以防止铅在冠状窦内发生移位或移位。 引导系统还可以包括适于将引线引导到冠状静脉窦静脉，大心静脉，左边缘静脉，左后脑室静脉和小心静脉中的至少一个的探针。 探针在其远端部分逐渐变细，以在冠状窦区域内提供增强的机动性和可操纵性。 引导系统还可以包括有助于将引入引入心脏的导引器。