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公开(公告)号：US07320971B2
公开(公告)日：2008-01-22
申请号：US10530904
申请日：2003-10-09
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , C07J71/00
CPC分类号： C07D513/20 , C07F7/1804 , C07J21/00
摘要： 2″ oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″ oxo-voruscharin compound or derivatives thereof. The disclosed 2″ oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
摘要翻译： 公开了2'-氧代 - 罗红沙星化合物及其衍生物，以及包含2'-氧代 - 罗喋呤化合物或其衍生物的药物组合物。 所公开的2'' - 氧化 - 罗瑞沙林化合物及其衍生物可用于癌症治疗。 还公开了使用所公开的化合物治疗癌症的方法。
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公开(公告)号：US20080261935A1
公开(公告)日：2008-10-23
申请号：US11956244
申请日：2007-12-13
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , A61P35/00
CPC分类号： C07J21/00
摘要： Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
摘要翻译： 公开了包含2'-氧代 - 罗瑞沙林和衍生物的化合物和药物组合物。 化合物和药物组合物可用于治疗癌症，特别是胰腺癌的方法。
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公开(公告)号：US07981875B2
公开(公告)日：2011-07-19
申请号：US11956244
申请日：2007-12-13
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , C07J71/00
CPC分类号： C07J21/00
摘要： Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
摘要翻译： 公开了包括2“氧代 - 罗香兰和衍生物的化合物和药物组合物。 化合物和药物组合物可用于治疗癌症，特别是胰腺癌的方法。
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4.发明申请NAPTHALIMIDE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREFROM 审中-公开NAPTHALIMIDE衍生物，其生产方法及其药物组合物公开(公告)号：US20070117836A1
公开(公告)日：2007-05-24
申请号：US11556571
申请日：2006-11-03
IPC分类号： A61K31/473 , C07D221/04
CPC分类号： C07D221/14 , C07D405/12
摘要： Novel substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods for making such derivatives.
摘要翻译： 新型取代萘酰亚胺衍生物，其药学上可接受的盐和溶剂合物可用于制备用于治疗细胞增殖性疾病如癌症的药物组合物。 本发明还提供了制备这种衍生物的方法。
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5.发明申请公开(公告)号：US20090221628A1
公开(公告)日：2009-09-03
申请号：US12313186
申请日：2008-11-17
申请人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van Den Hove , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van Den Hove , Francis Darro , Robert Kiss
IPC分类号： A61K31/435 , A61P35/00
CPC分类号： A61K31/435 , A61K45/06 , A61K2300/00
摘要： Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods of treating specific types of cancer such as prostate, esophageal, glioblastoma, gliosarcoma, NSCLC, head and neck, and breast with the compounds described herein alone and in combination with antineoplastic agents.
摘要翻译： 新的脲基取代的萘二甲酰亚胺衍生物，其药学上可接受的盐和溶剂合物可用于制备用于治疗细胞增殖性疾病如癌症的药物组合物。 本发明还提供了单独使用本文所述的化合物和抗肿瘤剂组合治疗特定类型的癌症例如前列腺，食管，胶质母细胞瘤，胶质瘤，NSCLC，头颈部和乳腺的方法。
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6.发明申请5-Urea Substituted Naphthalimide Derivatives, Methods of Production and Pharmaceutical Compositions for Treating Cancer 审中-公开5-尿素取代萘酰亚胺衍生物，生产方法和药物组合物治疗癌症公开(公告)号：US20090118321A1
公开(公告)日：2009-05-07
申请号：US12227090
申请日：2007-05-07
申请人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van den Hove , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van den Hove , Francis Darro , Robert Kiss
IPC分类号： A61K31/473 , C07D221/06 , A61P35/00
CPC分类号： C07D221/14
摘要： Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods for making such derivatives through hydrolysis of known compounds.
摘要翻译： 新的脲基取代的萘二甲酰亚胺衍生物，其药学上可接受的盐和溶剂合物可用于制备用于治疗细胞增殖性疾病如癌症的药物组合物。 本发明还提供了通过已知化合物的水解制备此类衍生物的方法。
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公开(公告)号：US20090232907A1
公开(公告)日：2009-09-17
申请号：US12313179
申请日：2008-11-17
申请人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van Den Hove , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van Den Hove , Francis Darro , Robert Kiss
IPC分类号： A61K33/24 , A61K31/4188 , A61K31/4166 , A61K31/473
CPC分类号： A61K31/4166 , A61K31/4188 , A61K31/473 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods of treating specific types of cancer such as prostate, esophageal, glioblastoma, gliosarcoma, NSCLC, head and neck, and breast with the compounds described herein alone and in combination with antineoplastic agents.
摘要翻译： 新的脲基取代的萘二甲酰亚胺衍生物，其药学上可接受的盐和溶剂合物可用于制备用于治疗细胞增殖性疾病如癌症的药物组合物。 本发明还提供了单独使用本文所述的化合物和抗肿瘤剂组合治疗特定类型的癌症例如前列腺，食管，胶质母细胞瘤，胶质瘤，NSCLC，头颈部和乳腺的方法。
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8.发明申请Compositions and methods for treatment of glioblastoma, gliosarcoma, NSCLC, and head and neck cancer 审中-公开用于治疗胶质母细胞瘤，神经胶质瘤，NSCLC和头颈部癌症的组合物和方法公开(公告)号：US20090186915A1
公开(公告)日：2009-07-23
申请号：US12313187
申请日：2008-11-17
申请人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van Den Hove , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Gentiane Simon , Mohamed El Yazidi , Jerome Tuti , Laurent Van Den Hove , Francis Darro , Robert Kiss
IPC分类号： A61K31/473 , A61P35/00
CPC分类号： A61K31/473 , A61K31/47 , A61K31/53 , A61K2300/00
摘要： Novel ureyl-substituted naphthalimide derivatives, pharmaceutically acceptable salts thereof and solvates thereof, are useful for making pharmaceutical compositions for the treatment of cell proliferative diseases such as cancer. The invention also provides methods of treating specific types of cancer such as prostate, esophageal, glioblastoma, gliosarcoma, NSCLC, head and neck, and breast with the compounds described herein alone and in combination with antineoplastic agents.
摘要翻译： 新的脲基取代的萘二甲酰亚胺衍生物，其药学上可接受的盐和溶剂合物可用于制备用于治疗细胞增殖性疾病如癌症的药物组合物。 本发明还提供了单独使用本文所述的化合物和抗肿瘤剂组合治疗特定类型的癌症例如前列腺，食管，胶质母细胞瘤，胶质瘤，NSCLC，头颈部和乳腺的方法。
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公开(公告)号：US20060166952A1
公开(公告)日：2006-07-27
申请号：US10530904
申请日：2003-10-09
申请人： Eric Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
CPC分类号： C07D513/20 , C07F7/1804 , C07J21/00
摘要： 2″oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″oxo-voruscharin compound or derivatives thereof. The disclosed 2″oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
摘要翻译： 公开了2''oxo-voruscharin化合物及其衍生物以及包含2''oxo-voruscharin化合物或其衍生物的药物组合物。 所公开的2''oxo-voruscharin化合物及其衍生物可用于癌症治疗。 还公开了使用所公开的化合物治疗癌症的方法。
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