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公开(公告)号：US20080261935A1
公开(公告)日：2008-10-23
申请号：US11956244
申请日：2007-12-13
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , A61P35/00
CPC分类号： C07J21/00
摘要： Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
摘要翻译： 公开了包含2'-氧代 - 罗瑞沙林和衍生物的化合物和药物组合物。 化合物和药物组合物可用于治疗癌症，特别是胰腺癌的方法。
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公开(公告)号：US07981875B2
公开(公告)日：2011-07-19
申请号：US11956244
申请日：2007-12-13
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , C07J71/00
CPC分类号： C07J21/00
摘要： Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
摘要翻译： 公开了包括2“氧代 - 罗香兰和衍生物的化合物和药物组合物。 化合物和药物组合物可用于治疗癌症，特别是胰腺癌的方法。
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公开(公告)号：US07320971B2
公开(公告)日：2008-01-22
申请号：US10530904
申请日：2003-10-09
申请人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Van Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Germaine Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
IPC分类号： A61K31/585 , C07J71/00
CPC分类号： C07D513/20 , C07F7/1804 , C07J21/00
摘要： 2″ oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″ oxo-voruscharin compound or derivatives thereof. The disclosed 2″ oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
摘要翻译： 公开了2'-氧代 - 罗红沙星化合物及其衍生物，以及包含2'-氧代 - 罗喋呤化合物或其衍生物的药物组合物。 所公开的2'' - 氧化 - 罗瑞沙林化合物及其衍生物可用于癌症治疗。 还公开了使用所公开的化合物治疗癌症的方法。
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公开(公告)号：US20060057237A1
公开(公告)日：2006-03-16
申请号：US10530905
申请日：2003-10-09
申请人： Francis Darro , Jean-Claude Braekman , Pierre Guissou , Odile Nacoulma , Mohamed El Yazidi , Janique Dewelle , Rob Van Ginkel , Marc Van Damme , Robert Kiss
发明人： Francis Darro , Jean-Claude Braekman , Pierre Guissou , Odile Nacoulma , Mohamed El Yazidi , Janique Dewelle , Rob Van Ginkel , Marc Van Damme , Robert Kiss
IPC分类号： A61K36/185
CPC分类号： A61K36/27
摘要： Extracts of the plant Calotropis procera, having a pharmacological activity, in particular an anti-poisonous activity, and active compounds isolated thereof are described. Furthermore, methods for the extraction of the extracts are disclosed. Also, a pharmaceutical composition or product for the treatment of cancer which includes an effective amount of the described extracts or an active compound thereof, a therapeutic compound and optionally a pharmaceutical acceptable carrier are described.
摘要翻译： 描述了具有药理学活性，特别是抗毒活性的植物提取物及其分离的活性化合物。 此外，公开了提取提取物的方法。 此外，还描述了包含有效量的所述提取物或其活性化合物，治疗化合物和任选的药学上可接受的载体的用于治疗癌症的药物组合物或产品。
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公开(公告)号：US20060166952A1
公开(公告)日：2006-07-27
申请号：US10530904
申请日：2003-10-09
申请人： Eric Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
发明人： Eric Quaquebeke , Jean-Claude Braekman , Gentiane Simon , Pierre Guissou , Odile Nacoulma , Janique Dewelle , Francis Darro , Robert Kiss
CPC分类号： C07D513/20 , C07F7/1804 , C07J21/00
摘要： 2″oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″oxo-voruscharin compound or derivatives thereof. The disclosed 2″oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.
摘要翻译： 公开了2''oxo-voruscharin化合物及其衍生物以及包含2''oxo-voruscharin化合物或其衍生物的药物组合物。 所公开的2''oxo-voruscharin化合物及其衍生物可用于癌症治疗。 还公开了使用所公开的化合物治疗癌症的方法。
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公开(公告)号：US20060149045A1
公开(公告)日：2006-07-06
申请号：US10538993
申请日：2003-12-18
申请人： Jean-Claude Braekman , Eric Quaquebeke , Laurent Ingrassia , Janique Dewelle , Robert Kiss , Francis Darro
发明人： Jean-Claude Braekman , Eric Quaquebeke , Laurent Ingrassia , Janique Dewelle , Robert Kiss , Francis Darro
摘要： The present invention relates to novel steroid compounds of Formula (IB) having anti-tumor activity. The present invention also relates to a method for the preparation of said steroid compounds. The invention further relates to a pharmaceutical composition comprising an effective amount of said steroid compounds. Furthermore, the present invention concerns the use of said steroid compounds as a medicament and in the preparation of a medicament for the treatment of cancer. The present invention also relates to the use of a steroid compound or a pharmaceutical composition comprising said steroid compound according to the invention in the treatment of cancer.
摘要翻译： 本发明涉及具有抗肿瘤活性的式（IB）的新型类固醇化合物。 本发明还涉及一种制备所述类固醇化合物的方法。 本发明还涉及包含有效量的所述类固醇化合物的药物组合物。 此外，本发明涉及所述类固醇化合物作为药物和制备用于治疗癌症的药物的用途。 本发明还涉及包含根据本发明的所述类固醇化合物的类固醇化合物或药物组合物在治疗癌症中的用途。
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公开(公告)号：US20070123473A1
公开(公告)日：2007-05-31
申请号：US10582121
申请日：2004-12-17
申请人： Jean-Claude Braekman , Laurent Ingrassia , Prosper Nshimyumukiza , Eric Van Quaquebeke , Janique Dewelle , Laurent Van Den Hove , Robert Kiss , Francis Darro
发明人： Jean-Claude Braekman , Laurent Ingrassia , Prosper Nshimyumukiza , Eric Van Quaquebeke , Janique Dewelle , Laurent Van Den Hove , Robert Kiss , Francis Darro
IPC分类号： A61K31/704 , A61K31/58 , C07J43/00
CPC分类号： C07J43/00
摘要： Glycosylated steroid compounds having anti-migratory activity and methods for their preparation are disclosed. Pharmaceutical compositions having an effective amount of the glycosylated steroid compounds are also disclosed. The glycosylated steroid compounds may be used as a medicament. Preparation of medicaments containing the glycosylated steroid compounds for treatment of diseases associated with cell migration, in particular, cancer, are disclosed. The glycosylated steroid compounds or pharmaceutical compositions containing the glycosylated steroid compounds may be used in the treatment of diseases associated with cell migration, in particular for the treatment of cancer.
摘要翻译： 公开了具有抗迁移活性的糖基化类固醇化合物及其制备方法。 还公开了具有有效量的糖基化类固醇化合物的药物组合物。 糖基化类固醇化合物可以用作药物。 公开了含有用于治疗与细胞迁移相关的疾病，特别是癌症的糖基化类固醇化合物的药物的制备。 含有糖基化类固醇化合物的糖基化类固醇化合物或药物组合物可用于治疗与细胞迁移有关的疾病，特别是用于治疗癌症。
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公开(公告)号：US06972111B1
公开(公告)日：2005-12-06
申请号：US09936124
申请日：2000-03-10
申请人： Franz Kunisch , Martin Kugler , Jean-Claude Braekman , Mark Plehiers , Gabriele Ferrari , Marcel Vos
发明人： Franz Kunisch , Martin Kugler , Jean-Claude Braekman , Mark Plehiers , Gabriele Ferrari , Marcel Vos
IPC分类号： C07C291/10 , A01N37/18 , A01N37/34 , A01N47/40 , A01N47/44 , A01N47/46 , A01N47/48 , C07C233/02 , C07C265/08 , C07C331/20 , C07C331/22 , C07C331/24 , C09D5/16 , B08B17/00
CPC分类号： A01N37/34 , A01N37/18 , A01N47/40 , A01N47/44 , A01N47/46 , C07C233/02 , C07C265/08 , C07C331/24 , C07C2603/26 , C09D5/1625
摘要： The invention relates to new and known compounds as well as methods for preventing the attachment of aquatic organisms to surfaces which are submerged for extensive periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with new isonitrile, formamide, isocyanate and isothiocyanate anti-fouling agents.
摘要翻译： 本发明涉及新的和已知的化合物以及用于防止水生生物附着到在水中浸没大量时间的表面的方法。 更具体地说，本发明涉及用新的异腈，甲酰胺，异氰酸酯和异硫氰酸酯防污剂保护浸没表面。
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公开(公告)号：US06929685B2
公开(公告)日：2005-08-16
申请号：US10473172
申请日：2002-03-27
申请人： Daniel Bernard , Jean-Claude Braekman , Gabriele Ferrari , Martin Kugler , Franz Kunisch , Mark Plehiers , Marcel Vos
发明人： Daniel Bernard , Jean-Claude Braekman , Gabriele Ferrari , Martin Kugler , Franz Kunisch , Mark Plehiers , Marcel Vos
IPC分类号： A01N37/18 , A01N25/04 , A01N35/10 , A01N37/26 , A01N37/30 , A01N37/44 , A01N37/46 , A01N41/06 , A01N47/12 , A01N47/28 , A01N47/40 , A01N47/46 , C07C211/27 , C07C229/12 , C07C229/24 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/47 , C07C265/04 , C07C271/14 , C07C271/16 , C07C291/10 , C07C311/03 , C07C311/16 , C07C331/20 , C09D5/16 , C09D7/80 , C09D201/00 , A01N33/02
CPC分类号： C07C311/03 , A01N35/10 , A01N37/30 , A01N37/44 , A01N47/12 , A01N47/28 , C07C211/27 , C07C229/12 , C07C229/24 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/47 , C07C265/04 , C07C271/14 , C07C271/16 , C07C291/10 , C07C311/16 , C07C331/20 , C09D5/1625
摘要： The invention relates to methods for preventing the attachment of aquatic organisms to surfaces that are submerged for extension periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with alkylamine derivatives as antifouling agents. The invention is beneficiary for the environment in that it will permit the use of copper- and tin-free paints.
摘要翻译： 本发明涉及防止水生生物附着在水中延伸一段时间的表面的方法。 更具体地说，本发明涉及用作为防污剂的烷基胺衍生物的浸没表面的保护。 本发明是环境的受益者，因为它将允许使用无铜和无锡涂料。
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