公开(公告)号：US20070283746A1

公开(公告)日：2007-12-13

申请号：US10586114

申请日：2005-01-18

申请人： Geoff Gerhardt ,  James Jorgenson ,  Keith Fadgen

发明人： Geoff Gerhardt ,  James Jorgenson ,  Keith Fadgen

IPC分类号： G01N30/16 ,  G01N30/22

CPC分类号： G01N30/22 ,  G01N30/36 ,  G01N2030/385 ,  Y10T436/2575

摘要： An injection device (10) includes a carrier inlet (40), a sample inlet (46), waste outlet (44) and a chamber outlet (64) attached to separation column (66). Valves (52, 54, 56) are used to control flow such that sample flows into chamber (22) and is carried into the chamber outlet (42).

摘要翻译： 注射装置（10）包括载体入口（40），样品入口（46），废物出口（44）和连接到分离塔（66）的室出口（64）。 阀（52,54,56）用于控制流动，使得样品流入室（22）并被运送到室出口（42）中。

公开(公告)号：US20060113794A1

公开(公告)日：2006-06-01

申请号：US11072485

申请日：2005-03-04

申请人： Kenneth Plant ,  Sylvain Cormier ,  Geoff Gerhardt

发明人： Kenneth Plant ,  Sylvain Cormier ,  Geoff Gerhardt

IPC分类号： F16L19/06

CPC分类号： G01N30/6004 ,  G01N30/6034

摘要： The present invention is a capillary interconnection fitting and method of clamping a capillary in the fitting that separates a forward ferrule that holds the capillary from a secondary clamping device. The fitting comprises a sealing ferrule, a compression screw and a clamping device. The ferrule is fitted in a compression screw that mates to a fluidic component. The clamping device is decoupled from the ferrule and coupled to the compression screw.

摘要翻译： 本发明是一种毛细管互连配件和夹紧毛细管的方法，该毛细管将管状毛细管的前套管与二次夹紧装置分开。 配件包括密封套圈，压缩螺钉和夹紧装置。 套圈安装在与流体组件配合的压缩螺钉中。 夹紧装置与套圈脱钩并联接到压紧螺钉。

公开(公告)号：US20050109699A1

公开(公告)日：2005-05-26

申请号：US10723973

申请日：2003-11-26

申请人： Geoff Gerhardt ,  Keith Fadgen

发明人： Geoff Gerhardt ,  Keith Fadgen

IPC分类号： G01F1/36 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  B01D21/24 ,  B01D29/88

CPC分类号： G01F1/363 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/324 ,  G01N2030/326

摘要： A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pump and a flow-divider. A waste flow sensor is disposed in the waste flow path downstream of the splitter. The output signal of the waste flow sensor is subtracted from the output signal of the main flow sensor in a difference circuit. The difference signal is divided by the output signal from the main flow sensor in a divider circuit. The output of the divider circuit represents an empirical split ratio of the flow-divider and is independent of media composition.

摘要翻译： 一种用于在不依赖于操作流程中的纳米级传感器的情况下监视和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。 主流量传感器设置在泵和分流器之间的主流路中。 废液流量传感器设置在分流器下游的废流路中。 在差分电路中，从主流量传感器的输出信号中减去废液流量传感器的输出信号。 差分信号除以分流器电路中的主流量传感器的输出信号。 分压电路的输出表示分流器的经验分流比，并且与介质组成无关。

公开(公告)号：US20070068872A1

公开(公告)日：2007-03-29

申请号：US11533615

申请日：2006-09-20

申请人： Geoff Gerhardt ,  Christopher Benevides ,  Dennis DellaRovere

发明人： Geoff Gerhardt ,  Christopher Benevides ,  Dennis DellaRovere

IPC分类号： B01D15/08

CPC分类号： G01N30/88 ,  B01L3/502753 ,  B01L3/565 ,  B01L2400/0415 ,  B01L2400/0487 ,  B29C63/18 ,  B29C63/34 ,  B29L2023/00 ,  G01N30/32 ,  G01N30/6052 ,  G01N30/7233 ,  G01N2030/324

摘要： A chemical processing apparatus includes a separation column, a pump unit configured to support nano-flow processing, at least one fluid transport tube for transporting the fluid between the pump unit and the separation column, and a connector disposed adjacent to an inlet or outlet end of the at least one transport tube. The fluid transport tube and/or the separation column includes an outer tube of a metallic material, a fused-silica capillary disposed in the outer tube, and an intermediate tube including a polymeric material disposed between and bonded to both the outer tube and the capillary.

摘要翻译： 化学处理装置包括分离柱，构造成支撑纳米流程处理的泵单元，用于在泵单元和分离柱之间输送流体的至少一个流体输送管，以及邻近入口端或出口端设置的连接器 的至少一个输送管。 流体输送管和/或分离柱包括金属材料的外管，设置在外管中的熔融石英毛细管，以及包括设置在外管和毛细管之间并结合到外管和毛细管两端的聚合物材料的中间管 。

公开(公告)号：US20060053807A1

公开(公告)日：2006-03-16

申请号：US11081321

申请日：2005-03-16

申请人： Geoff Gerhardt ,  Theodore Dourdeville

发明人： Geoff Gerhardt ,  Theodore Dourdeville

IPC分类号： F25D21/00

CPC分类号： F16K13/10 ,  F16K31/002 ,  Y10T137/0391 ,  Y10T137/2196 ,  Y10T137/4643 ,  Y10T137/6579

摘要： Methods and devices for the management of cryogenic agents within analytical systems using freeze thaw valving having an expansion chamber that limits the flow of the cryogenic agent. The expansion chamber is fitted with an expansion nozzle through which a cryogen flows and a porous frit that allows the cryogen to be exhausted. The porous frit initially allows a rapid flow of cryogen into the expansion chamber. This rapid flow lowers the temperature of the expansion chamber causing fluid contents within a freeze thaw segment to freeze. As the cryogen expands into the expansion chamber and turns into a solid, the porous frit is occluded causing the rapid flow to be restricted. The restriction of the cryogen flow by the occlusion of the porous frit allows the freeze thaw valve to use significantly less cryogen. Sublimation of the cryogen trapped within the porous frit provides sufficient cooling to maintain the valve in its closed position.

摘要翻译： 使用具有限制低温剂流动的膨胀室的冻融阀在分析系统内管理低温剂的方法和装置。 膨胀室配有膨胀喷嘴，冷却剂通过该喷嘴流动，允许冷冻剂排出的多孔玻璃料。 多孔玻璃料最初允许冷冻剂快速流入膨胀室。 这种快速流动降低了膨胀室的温度，导致冻融段内的流体含量冻结。 当冷冻剂膨胀到膨胀室中并变成固体时，多孔玻璃料被堵塞，导致快速流动受到限制。 通过堵塞多孔玻璃料限制冷冻剂流允许冷冻解冻阀使用显着更少的冷冻剂。 捕集在多孔玻璃料内的冷冻剂的升华提供足够的冷却以将阀保持在其关闭位置。

公开(公告)号：US20050236055A1

公开(公告)日：2005-10-27

申请号：US10941216

申请日：2004-09-15

申请人： Robert Crocker ,  Pamela Caton ,  Geoff Gerhardt

发明人： Robert Crocker ,  Pamela Caton ,  Geoff Gerhardt

IPC分类号： F15C1/04 ,  F15C5/00 ,  F16K99/00

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0003 ,  F16K99/0021 ,  F16K99/0044 ,  F16K2099/0074 ,  F16K2099/0084 ,  Y10T137/0402 ,  Y10T137/1812 ,  Y10T137/2196 ,  Y10T137/4643

摘要： A freeze-thaw valve and a method of micro-machining the freeze-thaw valve is provided and includes a valve housing, wherein the valve housing defines a housing cavity and includes a housing inlet, a housing vent, a capillary tubing inlet and a capillary tubing outlet. A valve body is provided, at least a portion of which is lithographically constructed, wherein the valve body includes a refrigerant inlet, a refrigerant outlet and an expansion chamber. The expansion chamber is disposed to communicate the refrigerant inlet with the refrigerant outlet and includes a restriction region having a flow restriction. Additionally, the valve body is disposed within the housing cavity to form an insulating channel between the valve housing and the valve body.

摘要翻译： 提供了一种冻融阀和一种微型加工冻融阀的方法，包括阀壳体，其中阀壳体限定了壳体腔，并且包括壳体入口，壳体通风口，毛细管入口和毛细管 管道出口。 提供了阀体，其至少一部分是光刻构造的，其中阀体包括制冷剂入口，制冷剂出口和膨胀室。 膨胀室设置成使制冷剂入口与制冷剂出口连通，并且包括具有流动限制的限制区域。 此外，阀体设置在壳体腔内，以在阀壳体和阀体之间形成绝缘通道。

公开(公告)号：US20050160833A1

公开(公告)日：2005-07-28

申请号：US11088120

申请日：2005-03-22

申请人： Geoff Gerhardt ,  Keith Fadgen

发明人： Geoff Gerhardt ,  Keith Fadgen

IPC分类号： G01F1/684 ,  G01N30/32 ,  G01N30/64 ,  G01F1/708

CPC分类号： G01F1/6847 ,  G01N30/64 ,  G01N2030/324

摘要： A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.

公开(公告)号：US20050109698A1

公开(公告)日：2005-05-26

申请号：US10851497

申请日：2004-05-21

申请人： Geoff Gerhardt ,  Joseph Luongo

发明人： Geoff Gerhardt ,  Joseph Luongo

IPC分类号： G01F1/36 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  B01D15/08

CPC分类号： G01F1/68 ,  G01F1/363 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/324 ,  G01N2030/326 ,  G05D11/132

摘要： A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system. A first flow sensor is disposed in a first flow path between a first flow-divider and a fluidic tee. A second flow sensor is disposed in a second flow path between a second flow-divider and the fluidic tee. A first recycle flow restrictor is disposed in the first recycle flow path in fluid communication with the first flow-divider. A second recycle flow restrictor is disposed in the second The permeability of each recycle flow restrictor can be selected to produce a desired flow rate with each respective flow path. The output signals of the first and second flow sensors to control output of a pump within each flow path.

摘要翻译： 一种用于监测和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。 第一流量传感器设置在第一分流器和流体三通之间的第一流动路径中。 第二流量传感器设置在第二分流器和流体三通之间的第二流动路径中。 第一再循环流量限制器设置在与第一分流器流体连通的第一再循环流动路径中。 第二再循环流量限制器设置在第二循环流量限制器中。可以选择每个循环流量限制器的渗透率，以产生每个相应流动路径的期望流量。 第一和第二流量传感器的输出信号以控制每个流动路径内的泵的输出。