公开(公告)号：US09169934B2

公开(公告)日：2015-10-27

申请号：US14114330

申请日：2012-04-24

申请人： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

发明人： Bernard Bunner ,  Joseph Michienzi ,  Keith Fadgen

IPC分类号： F16K3/10 ,  F16K3/18 ,  F16K31/04 ,  G01N35/10 ,  G01N30/20

CPC分类号： F16K3/10 ,  F16K3/18 ,  F16K31/041 ,  G01N35/1097 ,  G01N2030/202 ,  Y10T137/0318

摘要： A method for switching a high pressure fluid includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.

摘要翻译： 用于切换高压流体的方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。 转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。 控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。 控制信号响应转子的旋转状态。 转子和定子的平面之间的总的力基本上等于固定力和可控力之和。 该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。

公开(公告)号：US20130071867A1

公开(公告)日：2013-03-21

申请号：US13384914

申请日：2010-07-16

申请人： Keith Fadgen

发明人： Keith Fadgen

IPC分类号： C12M1/00

CPC分类号： C12M45/09 ,  G01N30/06 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/067 ,  G01N2030/8831 ,  G01N2030/8881

摘要： The invention feature devices and methods for preserving and processing samples comprising a fluid having deuterated compounds. The device of the present invention comprises a housing defining a first chamber and a second chamber. The first chamber is heated to an elevated temperature and receives the sample and performs a digestion process on the sample at the elevated temperature. The second chamber is cooled to a low temperature and receives the deuterated digested sample from the first chamber and performs one or more separation steps to isolate an analyte. The device of further comprises conduit means for containing and moving the sample into the first chamber to form a digested sample. The conduit means moves the digested sample from the first chamber to the second chamber to separate the sample to form at least one analyte. The analyte is maintained at the low temperature to preserve its deuterated form.

摘要翻译： 本发明的特征在于用于保存和处理包含具有氘代化合物的流体的样品的装置和方法。 本发明的装置包括限定第一室和第二室的壳体。 将第一室加热到升高的温度并接收样品并在升高的温度下对样品进行消化处理。 将第二室冷却至低温，并从第一室接收氘代消化的样品，并执行一个或多个分离步骤以分离分析物。 该装置还包括用于容纳和移动样品到第一室中以形成消化的样品的导管装置。 导管装置将消化的样品从第一室移动到第二室以分离样品以形成至少一种分析物。 分析物保持在低温以保持其氘化形式。

公开(公告)号：US08173070B2

公开(公告)日：2012-05-08

申请号：US10586114

申请日：2005-01-18

申请人： Geoff C. Gerhardt ,  James W. Jorgenson ,  Keith Fadgen

发明人： Geoff C. Gerhardt ,  James W. Jorgenson ,  Keith Fadgen

IPC分类号： G01N30/16

CPC分类号： G01N30/22 ,  G01N30/36 ,  G01N2030/385 ,  Y10T436/2575

摘要： An injection device (10) includes a carrier inlet (40), a sample inlet (46), waste outlet (44) and a chamber outlet (64) attached to separation column (66). Valves (52, 54, 56) are used to control flow such that sample flows into chamber (22) and is carried into the chamber outlet (42).

摘要翻译： 注射装置（10）包括载体入口（40），样品入口（46），废物出口（44）和连接到分离塔（66）的室出口（64）。 阀（52,54,56）用于控制流动，使得样品流入室（22）并被运送到室出口（42）中。

公开(公告)号：US20110278214A1

公开(公告)日：2011-11-17

申请号：US12811158

申请日：2008-12-16

申请人： Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

发明人： Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

IPC分类号： B01D15/08 ,  B23P19/00

CPC分类号： B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

摘要： A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

摘要翻译： 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内部导管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。

公开(公告)号：US09115815B2

公开(公告)日：2015-08-25

申请号：US13808263

申请日：2011-08-26

申请人： Geoff C. Gerhardt ,  Keith Fadgen

发明人： Geoff C. Gerhardt ,  Keith Fadgen

IPC分类号： F16K11/074 ,  F16K11/00

CPC分类号： F16K11/00 ,  F16K11/0743 ,  Y10T137/0318 ,  Y10T137/86863

摘要： Variable-volume injection valves include a stator and a rotor. The stator has a first port, a second port, and a contact surface with a groove therein. The first port opens into the stator groove. The rotor has a contact surface with a groove therein. The contact surface of the rotor is urged against the contact surface of the stator such that the rotor groove opposes the stator groove with one end of the rotor groove overlapping the stator groove and the opposite end of the rotor groove overlapping the second port of the stator. The overlapping grooves of the rotor and stator provide a fluidic channel between the first and second ports of the stator. The rotor is movable with respect to the stator in order to vary a length of overlap between their overlapping grooves.

摘要翻译： 可变容积喷射阀包括定子和转子。 定子具有第一端口，第二端口和与其中的凹槽的接触表面。 第一端口通向定子槽。 转子具有与其中的凹槽的接触表面。 转子的接触表面被推靠在定子的接触表面上，使得转子槽与定子槽相对，转子槽的一端与定子槽重叠，转子槽的相对端与定子的第二端重叠 。 转子和定子的重叠槽在定子的第一和第二端口之间提供流体通道。 转子相对于定子是可移动的，以便改变其重叠槽之间的重叠长度。

公开(公告)号：US09103814B2

公开(公告)日：2015-08-11

申请号：US12280585

申请日：2007-03-16

申请人： Steven J. Ciavarini ,  Stanley P. Pensak, Jr. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

发明人： Steven J. Ciavarini ,  Stanley P. Pensak, Jr. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

IPC分类号： G01N30/34

CPC分类号： G01N30/34 ,  G01N30/32 ,  G01N2030/326 ,  G05D11/132

摘要： A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

摘要翻译： 用于色谱装置的溶剂递送子系统执行溶剂的相对低压，高流动混合以形成梯度并随后将高梯度梯度递送到分离塔。 梯度的混合是独立的，并且不干扰梯度递送。 为了形成梯度，将水性泵和有机泵的输出混合以填充储存毛细管，同时从储存毛细管的下游点排放到大气中。 梯度形成后，关闭空气，溶剂输送系统升高至高压，只有水泵运行梯度输送。 为了保持流体流的完整性，溶剂输送系统使用前馈补偿并且控制选自管道装置中的压力和流量的至少一个参数以跟随逐渐斜坡。

公开(公告)号：US20080305555A1

公开(公告)日：2008-12-11

申请号：US12063093

申请日：2006-08-16

申请人： Edouard S. P. Bouvier ,  Dennis DellaRovere ,  Christopher C. Benevides ,  Keith Fadgen

发明人： Edouard S. P. Bouvier ,  Dennis DellaRovere ,  Christopher C. Benevides ,  Keith Fadgen

IPC分类号： G01N30/72 ,  H01B1/12 ,  H01L21/00

CPC分类号： H01J49/04 ,  B01L3/5085 ,  Y10T436/24

摘要： A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface.

摘要翻译： 用于呈现用于MALDI或DIOS离子源的样品的装置，包括具有至少一个第一表面和至少一个第二表面的半导体晶片体，所述第一表面经化学修饰以将所述水性样品排斥到所述第二表面。

公开(公告)号：US20080121576A1

公开(公告)日：2008-05-29

申请号：US11959602

申请日：2007-12-19

申请人： Geoff C. Gerhardt ,  Keith Fadgen

发明人： Geoff C. Gerhardt ,  Keith Fadgen

IPC分类号： B01D17/12 ,  B01D15/08

CPC分类号： G01F1/363 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/324 ,  G01N2030/326

摘要： A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pump and a flow-divider. A waste flow sensor is disposed in the waste flow path downstream of the splitter. The output signal of the waste flow sensor is subtracted from the output signal of the main flow sensor in a difference circuit. The difference signal is divided by the output signal from the main flow sensor in a divider circuit. The output of the divider circuit represents an empirical split ratio of the flow-divider and is independent of media composition.

摘要翻译： 一种用于在不依赖于操作流程中的纳米级传感器的情况下监视和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。 主流量传感器设置在泵和分流器之间的主流路中。 废液流量传感器设置在分流器下游的废流路中。 在差分电路中，从主流量传感器的输出信号中减去废液流量传感器的输出信号。 差分信号除以分流器电路中的主流量传感器的输出信号。 分压电路的输出表示分流器的经验分流比，并且与介质组成无关。

公开(公告)号：US20070283746A1

公开(公告)日：2007-12-13

申请号：US10586114

申请日：2005-01-18

申请人： Geoff Gerhardt ,  James Jorgenson ,  Keith Fadgen

发明人： Geoff Gerhardt ,  James Jorgenson ,  Keith Fadgen

IPC分类号： G01N30/16 ,  G01N30/22

CPC分类号： G01N30/22 ,  G01N30/36 ,  G01N2030/385 ,  Y10T436/2575

摘要： An injection device (10) includes a carrier inlet (40), a sample inlet (46), waste outlet (44) and a chamber outlet (64) attached to separation column (66). Valves (52, 54, 56) are used to control flow such that sample flows into chamber (22) and is carried into the chamber outlet (42).

摘要翻译： 注射装置（10）包括载体入口（40），样品入口（46），废物出口（44）和连接到分离塔（66）的室出口（64）。 阀（52,54,56）用于控制流动，使得样品流入室（22）并被运送到室出口（42）中。

公开(公告)号：US09983178B2

公开(公告)日：2018-05-29

申请号：US14238278

申请日：2012-08-23

申请人： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille, Sr. ,  Raymond P. Fisk ,  Frank John Marzalkowski, Jr.

发明人： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille, Sr. ,  Raymond P. Fisk ,  Frank John Marzalkowski, Jr.

IPC分类号： G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B05B5/16 ,  G01N30/72 ,  B01D15/18

CPC分类号： B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

摘要： Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.