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    Flow cells for high density array chips
    4.
    发明授权
    Flow cells for high density array chips 有权

    公开(公告)号：US09803239B2

    公开(公告)日：2017-10-31

    申请号：US13840482

    申请日：2013-03-15

    申请人： Complete Genomics, Inc.

    发明人： Bill J. Peck ,  Mark Fuller ,  Daniel West ,  Anthony Delacruz

    IPC分类号： B01L3/00 ,  C12Q1/68 ,  G01N21/05

    CPC分类号： C12Q1/6874 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/565 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0877 ,  G01N21/05

    摘要： Biochemical flow cells having sealed inlets and outlets are provided for performing high-volume assays on macromolecules. In one example embodiment, a flow cell with detachable inlet and outlet connectors comprises an inlet manifold, a coverslip, and a substrate disposed below the coverslip to form a reaction chamber, where the substrate is disposed to partially cover the inlet manifold such that a slit is formed along an entire edge of the substrate where fluids can flow from the inlet manifold through the slit, around substantially the entire edge of the substrate, and into the reaction chamber at equalized pressure and without bubbles. In another embodiment, a flow cell comprises an outlet manifold, two or more flow regions each connected to its own loading port via its own flow distribution funnel, each loading port connected to the outlet manifold, and plugs in a wall of the outlet manifold opposite each loading port, such that when a plug is absent from the wall of the outlet manifold, a loading tip may be inserted in its place, passing through the outlet manifold and connecting directly to a loading port.

    MEASURING ARRANGEMENT HAVING A SUPPORT ELEMENT AND A SENSOR
    8.
    发明申请
    MEASURING ARRANGEMENT HAVING A SUPPORT ELEMENT AND A SENSOR 审中-公开
    具有支持元件和传感器的测量装置

    公开(公告)号：US20160256867A1

    公开(公告)日：2016-09-08

    申请号：US15029154

    申请日：2014-09-10

    申请人： ENDRESS+HAUSER FLOWTEC AG

    发明人： Christof Huber ,  Hagen Feth ,  Frank Steinhoff ,  Holger Reinecke

    IPC分类号： B01L3/00 ,  G01D11/30 ,  B01L9/00

    CPC分类号： B01L3/502 ,  B01L3/502715 ,  B01L3/565 ,  B01L9/52 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0832 ,  B01L2300/0887 ,  B01L2300/12 ,  G01D11/30 ,  G01N2030/6013

    摘要： A measuring arrangement comprising: a support element having a longitudinal axis, wherein a sensor for ascertaining a process variable of a gaseous or liquid fluid is arranged on the support element; and the sensor, wherein the sensor has a fluid duct, which extends within the sensor. The support element has a fluid duct, and for mechanical connection of the fluid duct with the fluid duct of the sensor a bonding layer, which extends over a portion of a surface of the support element and over a portion of a surface of the sensor. The bonding layer comprises at least one fluorinated polymer. The support element has for connection of the fluid duct of the support element with the fluid duct of the sensor, in each case, at least one connection element, which protrude from the support element perpendicularly to the longitudinal axis and which protrude inwardly into the fluid duct of the sensor. The connection elements are secured at least to a the sensor by means of a bonding layer, and wherein the bonding layer comprises a fluorinated polymer.

    摘要翻译： 一种测量装置，包括：具有纵向轴线的支撑元件，其中用于确定气态或液体流体的过程变量的传感器布置在所述支撑元件上; 和传感器，其中传感器具有在传感器内延伸的流体管道。 支撑元件具有流体管道，并且用于将流体管道与传感器的流体管道机械连接，粘合层在支撑元件的表面的一部分上方延伸并超过传感器表面的一部分。 粘合层包含至少一种含氟聚合物。 支撑元件用于将支撑元件的流体管道与传感器的流体管道连接，在每种情况下，至少一个连接元件，其从支撑元件垂直于纵向轴线突出并且向内突出到流体中 传感器的导管。 连接元件通过粘合层至少固定在传感器上，并且其中粘合层包括含氟聚合物。

    Fluid sample holders with piston valve
    9.
    发明授权
    Fluid sample holders with piston valve 有权
    带活塞阀的流体样品架

    公开(公告)号：US09404901B2

    公开(公告)日：2016-08-02

    申请号：US14234719

    申请日：2012-07-25

    申请人： Mats Lundkvist

    发明人： Mats Lundkvist

    IPC分类号： G01N30/16 ,  B01L3/00 ,  B01L3/02 ,  G01N1/28 ,  G01N30/04 ,  G01N30/18 ,  G01N30/20

    CPC分类号： G01N30/16 ,  B01L3/0217 ,  B01L3/52 ,  B01L3/565 ,  B01L3/567 ,  B01L2300/123 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/065 ,  G01N1/28 ,  G01N30/04 ,  G01N30/18 ,  G01N2030/204

    摘要： Disclosed is a fluid sample holder 20 for delivering or receiving a fluid sample to or from fluid processing equipment such as a chromatography column 5 (FIG. 1). The sample holder 20 comprises a sliding seal 25 within a reservoir. The sliding seal 25 is displaceable within the reservoir 15 by means of a fluid pressure differential and includes a valve 260 operable when the sliding seal reaches or substantially reaches an end of its displacement, said valve including a stem 251 having a tapered portion 259 for cooperating with a tapering aperture 262 having a complementary taper, for substantially preventing fluid flow when so cooperating, said stem 251 being displaceable away from said aperture 262 and out of said cooperation at said end of its displacement, to open the valve 260.

    摘要翻译： 公开了一种流体样品保持器20，用于将流体样品递送或接收到流体处理设备，例如色谱柱5（图1）。 样品保持器20包括在贮存器内的滑动密封件25。 滑动密封件25可通过流体压力差在储存器15内移动，并且包括当滑动密封件达到或基本上到达其位移的端部时可操作的阀门260，所述阀门包括具有锥形部分259的杆251，用于配合 具有锥形孔262具有互补的锥形，用于当如此配合时基本上防止流体流动，所述杆251可在远离所述孔262的​​位置移动并在其移动端部脱离所述协作以打开阀260。

    Zero dead volume robust fluidic connection system
    10.
    发明授权
    Zero dead volume robust fluidic connection system 有权
    零死体积坚固的流体连接系统

    公开(公告)号：US09322811B2

    公开(公告)日：2016-04-26

    申请号：US13674330

    申请日：2012-11-12

    申请人： Michael John McAdams ,  Milton Liu ,  George N. Proper

    发明人： Michael John McAdams ,  Milton Liu ,  George N. Proper

    IPC分类号： G01N30/00 ,  F16L19/02 ,  B01L3/00 ,  F16L19/065 ,  G01N30/16 ,  G01N30/60

    CPC分类号： G01N30/00 ,  B01L3/563 ,  B01L3/565 ,  B01L2300/0838 ,  F16L19/02 ,  F16L19/065 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/6039

    摘要： A fluidic connection system may comprise a port which includes a capillary tube receptacle with an end seal face and a threaded wall. The fluidic connection system may also comprise a capillary tube that includes a front end face for sealingly abutting against the end seal face of the port. On the capillary tube, a flange may be affixed at a distance from the front end face of the capillary tube. The fluidic connection system may further comprise a fitting nut that includes an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to the threaded wall of the port. The fitting nut may be slidably coupled with the capillary tube behind the flange. The distance at which the flange is affixed may be predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.

    摘要翻译： 流体连接系统可以包括端口，该端口包括具有端部密封面和螺纹壁的毛细管插座。 流体连接系统还可以包括毛细管，毛细管包括用于密封地抵靠端口的端部密封面的前端面。 在毛细管上，法兰可以与毛细管的前端面一定距离地固定。 流体连接系统还可包括装配螺母，其包括允许毛细管通过的轴向孔以及与端口的螺纹壁对应的匹配的螺纹壁。 接头螺母可以与法兰后面的毛细管可滑动地连接。 法兰固定的距离可以是预定的，使得当法兰由配合螺母向前推动时，毛细管的前端面直接抵靠端口的端部密封面。