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![SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS](/abs-image/US/2014/03/13/US20140072529A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140072529A1
公开(公告)日：2014-03-13
申请号：US14009599
申请日：2012-03-29
IPC分类号： C07D487/04 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/5377 , A61K45/06 , C07D487/04
摘要： The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
摘要翻译： 本发明涉及2-氨基-N-〔7-甲氧基-8-（3-吗啉-4-基丙氧基）-2,3-二氢咪唑并〔1,2-c〕喹唑啉-5-基〕嘧啶 式（II）的5-甲酰胺二盐酸盐：或其互变异构体，溶剂化物或水合物; - 制备所述二盐酸盐的方法; - 用于治疗和/或预防疾病的所述二盐酸盐; - 使用 的所述二盐酸盐用于制备用于治疗和/或预防疾病，特别是高增殖和/或血管生成障碍的药物，更特别是用于治疗或预防癌症，特别是肺癌， 特定的非小细胞肺癌，结肠直肠癌，黑素瘤，胰腺癌，肝细胞癌，胰腺癌，肝细胞癌或乳腺癌; - 包含所述二盐酸盐的药物组合物; 以及包含所述二盐酸盐与一种或多种其它药剂组合的药物组合。
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公开(公告)号：US08813506B2
公开(公告)日：2014-08-26
申请号：US13701893
申请日：2012-03-07
CPC分类号： F01K3/24 , F01K13/006 , F01K13/02 , F01K23/10 , Y02E20/16
摘要： A method is provided for connecting at least one further steam generator to a first steam generator in a power plant. The power plant includes at least two steam generators and a steam turbine, in which a fluid used to drive the steam turbine is conveyed in a fluid circuit having a plurality of steam systems. The steam systems are assigned individual steam generators and are able to be separated from one another by shut-off valves. The fluid of at least the first steam generator is connected to the steam turbine. The method involves opening the shut-off valve of at least one first steam system of the at least one further steam generator before the steam of the at least one further steam generator has reached approximately the same steam parameters as the steam of the first steam generator, so that steam can flow into the further steam generator.
摘要翻译： 提供了一种用于将至少一个另外的蒸汽发生器连接到发电厂中的第一蒸汽发生器的方法。 发电厂包括至少两个蒸汽发生器和汽轮机，其中用于驱动蒸汽轮机的流体在具有多个蒸汽系统的流体回路中输送。 蒸汽系统分配有各自的蒸汽发生器，并且能够通过截止阀彼此分离。 至少第一蒸汽发生器的流体连接到蒸汽轮机。 该方法包括在至少一个另外的蒸汽发生器的蒸汽已经达到与第一蒸汽发生器的蒸汽大致相同的蒸汽参数之前打开至少一个另外的蒸汽发生器的至少一个第一蒸汽系统的截止阀 ，使得蒸汽可以流入另外的蒸汽发生器。
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公开(公告)号：US20140000259A1
公开(公告)日：2014-01-02
申请号：US13701893
申请日：2012-03-07
CPC分类号： F01K3/24 , F01K13/006 , F01K13/02 , F01K23/10 , Y02E20/16
摘要： A method is provided for connecting at least one further steam generator to a first steam generator in a power plant. The power plant includes at least two steam generators and a steam turbine, in which a fluid used to drive the steam turbine is conveyed in a fluid circuit having a plurality of steam systems. The steam systems are assigned individual steam generators and are able to be separated from one another by shut-off valves. The fluid of at least the first steam generator is connected to the steam turbine. The method involves opening the shut-off valve of at least one first steam system of the at least one further steam generator before the steam of the at least one further steam generator has reached approximately the same steam parameters as the steam of the first steam generator, so that steam can flow into the further steam generator.
摘要翻译： 提供了一种用于将至少一个另外的蒸汽发生器连接到发电厂中的第一蒸汽发生器的方法。 发电厂包括至少两个蒸汽发生器和汽轮机，其中用于驱动蒸汽轮机的流体在具有多个蒸汽系统的流体回路中输送。 蒸汽系统分配有各自的蒸汽发生器，并且能够通过截止阀彼此分离。 至少第一蒸汽发生器的流体连接到蒸汽轮机。 该方法包括在至少一个另外的蒸汽发生器的蒸汽已经达到与第一蒸汽发生器的蒸汽大致相同的蒸汽参数之前打开至少一个另外的蒸汽发生器的至少一个第一蒸汽系统的截止阀 ，使得蒸汽可以流入另外的蒸汽发生器。
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![Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts](/abs-image/US/2019/08/20/US10383876B2/abs.jpg.150x150.jpg)
公开(公告)号：US10383876B2
公开(公告)日：2019-08-20
申请号：US14009599
申请日：2012-03-29
IPC分类号： C07D487/04 , A61K31/5377 , A61K45/06
摘要： The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and—to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
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