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    SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS
    1.
    发明申请
    SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS 审中-公开
    取代的2,3-二氢吲哚并[1,2-C]喹唑啉盐

    公开(公告)号：US20140072529A1

    公开(公告)日：2014-03-13

    申请号：US14009599

    申请日：2012-03-29

    Applicant: Jan-Georg Peters ,  Hans-Christian Militzer ,  Hartwig Müller

    Inventor： Jan-Georg Peters ,  Hans-Christian Militzer ,  Hartwig Müller

    IPC: C07D487/04 ,  A61K45/06 ,  A61K31/5377

    CPC classification number: A61K31/5377 ,  A61K45/06 ,  C07D487/04

    Abstract: The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.

    Abstract translation: 本发明涉及2-氨基-N-〔7-甲氧基-8-（3-吗啉-4-基丙氧基）-2,3-二氢咪唑并〔1,2-c〕喹唑啉-5-基〕嘧啶 式（II）的5-甲酰胺二盐酸盐：或其互变异构体，溶剂化物或水合物; - 制备所述二盐酸盐的方法; - 用于治疗和/或预防疾病的所述二盐酸盐; - 使用 的所述二盐酸盐用于制备用于治疗和/或预防疾病，特别是高增殖和/或血管生成障碍的药物，更特别是用于治疗或预防癌症，特别是肺癌， 特定的非小细胞肺癌，结肠直肠癌，黑素瘤，胰腺癌，肝细胞癌，胰腺癌，肝细胞癌或乳腺癌; - 包含所述二盐酸盐的药物组合物; 以及包含所述二盐酸盐与一种或多种其它药剂组合的药物组合。

    Vehicle rollover protection device
    2.
    发明授权
    Vehicle rollover protection device 失效

    公开(公告)号：US06988744B2

    公开(公告)日：2006-01-24

    申请号：US10371166

    申请日：2003-02-20

    Applicant: Hartwig Müller

    Inventor： Hartwig Müller

    IPC: B60R21/13

    CPC classification number: B60R21/13 ,  B60R2021/135

    Abstract: A rollover protection device for the passengers of a vehicle having a body and a lateral bulkhead includes a structural unit adapted to be mounted on one side of the vehicle body lateral bulkhead. The structural unit includes at least one extendible rollover bar, and a module beam being connectable in a force transmitting fashion with the lateral bulkhead and the vehicle body. The module beam extends crosswise to the longitudinal direction of the vehicle in an upper region of the lateral bulkhead, and at least one force transmission member contains the at least one rollover bar. The at least one force transmission member supports the module beam at the vehicle body bottom.

    Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
    3.
    发明授权
    Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts 有权

    公开(公告)号：US10383876B2

    公开(公告)日：2019-08-20

    申请号：US14009599

    申请日：2012-03-29

    Applicant: Jan-Georg Peters ,  Hans-Christian Militzer ,  Hartwig Müller

    Inventor： Jan-Georg Peters ,  Hans-Christian Militzer ,  Hartwig Müller

    IPC: C07D487/04 ,  A61K31/5377 ,  A61K45/06

    Abstract: The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and—to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.

    DEVICE FOR PLASMA TREATMENT OF WORKPIECES
    4.
    发明申请
    DEVICE FOR PLASMA TREATMENT OF WORKPIECES 审中-公开
    用于等离子体处理工作的装置

    公开(公告)号：US20130186336A1

    公开(公告)日：2013-07-25

    申请号：US13702662

    申请日：2011-06-03

    Applicant: Sönke Siebels ,  Hartwig Müller

    Inventor： Sönke Siebels ,  Hartwig Müller

    IPC: C23C16/458

    CPC classification number: C23C16/458 ,  B65D23/02 ,  C23C16/045 ,  C23C16/45561 ,  C23C16/511 ,  C23C16/54 ,  H01J37/3244 ,  H01J37/32733 ,  H01J37/32807 ,  H01J37/32899 ,  H01L21/68764 ,  H01L21/68771

    Abstract: A device for plasma treatment of workpieces. The workpiece is placed into a chamber of a processing station that can be at least partially evacuated. The plasma chamber is bounded by a chamber floor, a chamber cover, and a side chamber wall. The plasma chamber is coupled to a device for feeding and/or discharging process gases in a controlled manner. The plasma chamber is further disposed on a rotatable plasma wheel supported on a static base. At least one process gas channel is disposed in the region of the base, bounded at least in regions by a cover. The cover is implemented as part of the plasma wheel and includes at least one connection opening to the process gas channel. The connection opening can be coupled to an inner chamber by a connecting channel and at least one control valve.

    Abstract translation: 用于等离子体处理工件的装置。 将工件放置在可以至少部分抽真空的处理站的室中。 等离子体室由室底板，室盖和侧室壁限定。 等离子体室联接到用于以受控方式进料和/或排出处理气体的装置。 等离子体室进一步设置在支撑在静态基座上的可旋转等离子体轮上。 至少一个处理气体通道设置在基部的区域中，至少通过盖限定在区域中。 盖被实现为等离子体轮的一部分，并且包括至少一个连接到工艺气体通道的开口。 连接开口可以通过连接通道和至少一个控制阀联接到内室。

    Rollbar
    5.
    发明授权
    Rollbar 失效
    滚动条

    公开(公告)号：US06315326B1

    公开(公告)日：2001-11-13

    申请号：US09356442

    申请日：1999-07-19

    Applicant: Hartwig Müller ,  Robert Schweier

    Inventor： Hartwig Müller ,  Robert Schweier

    IPC: B60R2113

    CPC classification number: B60R21/13 ,  B60R2021/132 ,  B62D29/04

    Abstract: A rollbar for an open sports car which extends over the width of the vehicle, having a basic shell body which follows the rollbar shape and consists of molded two-dimensional material with longitudinal ribbings which are alternately raised toward the exterior and interior side of the rollbar. The rollbar shell is integrally formed from a pressed molding of fibrous composite plastic or metallic material and can include stiffening inserts which extend over at least part of the longitudinal extrusion of the shell. An anti-abrasion material can be integrally connected or embedded into the surface of the shell. The rollbar is light weight, optimally designed for individual types of loads and can be integrated into the car body in an esthetically appearing manner.

    Abstract translation: 一种用于开放式跑车的滚动条，其在车辆的宽度上延伸，具有跟随滚轮形状的基本壳体，并且包括具有纵向肋条的模制二维材料，所述纵向肋条朝着滚动条的外侧和内侧交替地升高 。 辊筒外壳由纤维复合塑料或金属材料的压制成型一体地形成，并且可以包括在外壳的纵向挤压的至少一部分上延伸的加强插入件。 防磨损材料可以一体地连接或嵌入到壳体的表面中。 滚动条重量轻，优化设计适用于各种类型的载荷，可以以美观的方式整合到车体内。

    Rollover protection device
    10.
    发明授权
    Rollover protection device 失效
    翻转保护装置

    公开(公告)号：US07438317B2

    公开(公告)日：2008-10-21

    申请号：US10548464

    申请日：2004-02-10

    Applicant: Stephan Röhner ,  Hartwig Müller

    Inventor： Stephan Röhner ,  Hartwig Müller

    IPC: B60R21/13

    CPC classification number: B60R21/13 ,  B60R2021/135

    Abstract: A rollover protection device includes a cassette housing which guides an extendable rollover bar. The cassette housing includes guidances for the rollover bar. The rollover bar is a single shell or multi-shell form part made of fibre reinforced plastic and has shell edge regions which at least partially extend parallel to the extension direction. The cassette housing is a hollow profile made from high strength material and is closed around the rollover bar and the guidance. The guidance is a plastic form part engaging at a shell edge region, is secured within the hollow profile and protrudes from the hollow profile at least downwards.

    Abstract translation: 翻转保护装置包括引导可伸缩翻转杆的盒壳体。 盒式外壳包括翻转杆的指导。 翻转杆是由纤维增强塑料制成的单壳或多壳形单元，并具有平行于延伸方向至少部分延伸的壳边缘区域。 盒式外壳是由高强度材料制成的中空型材，并围绕翻车杆和导向装置封闭。 引导件是接合在外壳边缘区域的塑料形式部件，固定在中空型材内并且至少向下从中空型材凸出。

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