利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.015 秒)

    Substituted naphthyridinone derivatives
    1.
    发明授权
    Substituted naphthyridinone derivatives 失效
    取代的萘啶酮衍生物

    公开(公告)号：US07728141B2

    公开(公告)日：2010-06-01

    申请号：US10576796

    申请日：2004-10-29

    申请人： John S. Debenham ,  George A. Doss ,  Christina B. Madsen-Duggan ,  Thomas F. Walsh

    发明人： John S. Debenham ,  George A. Doss ,  Christina B. Madsen-Duggan ,  Thomas F. Walsh

    IPC分类号： C07D471/04 ,  A61K31/4375

    CPC分类号： C07D471/04 ,  A61K31/4375 ,  C07D471/14

    摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

    摘要翻译： 结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。 本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管 事故和头部创伤，焦虑症，压力，癫痫，帕金森病，运动障碍和精神分裂症。 这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

    Inhibitors of HIV protease
    3.
    发明授权
    Inhibitors of HIV protease 失效
    HIV蛋白酶抑制剂

    公开(公告)号：US5250563A

    公开(公告)日：1993-10-05

    申请号：US951927

    申请日：1992-09-25

    申请人： Shieh-Shung T. Chen ,  George A. Doss ,  Russell B. Lingham

    发明人： Shieh-Shung T. Chen ,  George A. Doss ,  Russell B. Lingham

    IPC分类号： C07D209/54 ,  A61K31/40 ,  C07D209/56

    CPC分类号： C07D209/54

    摘要： Novel cytochalasins are the biotransformed products after incubation with a substrate in a culture of the microorganism Kibdelosporangium sp. (Merck Culture Collection MA 6559), ATCC No. 53771. The compounds of the present invention inhibit HIV protease and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines.

    摘要翻译： 新型细胞松弛素是在微生物克氏弧菌培养物中与底物孵育后的生物转化产物。 （Merck Culture Collection MA 6559），ATCC编号53771.本发明的化合物抑制HIV蛋白酶，可用于预防或治疗HIV的感染和治疗AIDS，作为化合物，药学上可接受的盐，药物 组合成分，无论作为前药还是作为其他抗病毒药，抗感染剂，免疫调节剂，抗生素或疫苗的组合。