公开(公告)号：US20070184071A1

公开(公告)日：2007-08-09

申请号：US11644095

申请日：2006-12-22

申请人： William Hausdorff ,  George Siber ,  Peter Paradiso ,  A. Prasad

发明人： William Hausdorff ,  George Siber ,  Peter Paradiso ,  A. Prasad

IPC分类号： A61K39/09 ,  C07K14/31

CPC分类号： A61K47/646 ,  A61K39/092 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.

摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。 还提供了制备包含肺炎链球菌血清型19A多糖的免疫原性缀合物的方法，其中血清型19A多糖与载体蛋白共冻干，并通过还原胺化机制在二甲基亚砜（DMSO）中进行偶联。

公开(公告)号：US07223411B1

公开(公告)日：2007-05-29

申请号：US08278601

申请日：1994-07-21

申请人： David Knipe ,  Robert Finberg ,  George Siber

发明人： David Knipe ,  Robert Finberg ,  George Siber

IPC分类号： A61K39/245

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16661

摘要： A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but incapable of completing a replicative cycle, and it is capable of eliciting a protective immune response in that mammal. The mutated herpesvirus is also capable of treating immunomodulatory or immunoregulatory diseases. The mutation occurs in at least one gene encoding a protein essential for replication of the virus, so that the mutation renders the virus replication defective.

摘要翻译： 一种疱疹病毒疫苗，其包含悬浮在药学上可接受的载体中的突变疱疹病毒。 突变的疱疹病毒能够感染待接种的哺乳动物的细胞，但不能完成复制循环，并且能够在该哺乳动物中引发保护性免疫应答。 突变的疱疹病毒也能够治疗免疫调节或免疫调节疾病。 该突变发生在编码病毒复制必需蛋白质的至少一个基因中，从而导致病毒复制有缺陷。

公开(公告)号：US20070231340A1

公开(公告)日：2007-10-04

申请号：US11644924

申请日：2006-12-22

申请人： William Hausdorff ,  George Siber ,  Peter Paradiso ,  A. Prasad

发明人： William Hausdorff ,  George Siber ,  Peter Paradiso ,  A. Prasad

IPC分类号： A61K38/00 ,  C07K14/00

CPC分类号： A61K39/092 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C07K14/3156

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.

摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。 还描述了一种用于制备包含与载体蛋白共价连接的肺炎链球菌血清型3多糖的免疫原性缀合物的方法，该方法包括在二价阳离子存在下对多糖进行高碘酸氧化。

公开(公告)号：US20060228380A1

公开(公告)日：2006-10-12

申请号：US11395593

申请日：2006-03-31

申请人： William Hausdorff ,  George Siber ,  Peter Paradiso

发明人： William Hausdorff ,  George Siber ,  Peter Paradiso

IPC分类号： A61K39/09

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.

摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。

公开(公告)号：US20070184072A1

公开(公告)日：2007-08-09

申请号：US11644207

申请日：2006-12-22

申请人： William Hausdorff ,  George Siber ,  Peter Paradiso ,  A. Prasad

发明人： William Hausdorff ,  George Siber ,  Peter Paradiso ,  A. Prasad

IPC分类号： A61K39/09 ,  C07K14/31

CPC分类号： A61K39/092 ,  A61K39/385 ,  A61K2039/6031 ,  A61K2039/6037

摘要： An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.

摘要翻译： 描述了具有13种不同的多糖 - 蛋白质缀合物和任选的基于铝的佐剂的免疫原性组合物。 每个缀合物含有由与载体蛋白缀合的不同血清型肺炎链球菌（1,3,4,5,6A，6B，7F，9V，14,18C，19A，19F和23F）制备的荚膜多糖。 配制成疫苗的免疫原性组合增加了全球婴儿和幼儿肺炎球菌病的覆盖率，并为不依赖于血清群交叉保护的限制的血清型6A和19A提供了覆盖。 还描述了一种用于制备包含与载体蛋白共价连接的肺炎链球菌血清型1多糖的免疫原性缀合物的方法，该方法包括在碱性pH缓冲液中通过轻度水解部分脱-O-乙酰化多糖。

公开(公告)号：US20060263847A1

公开(公告)日：2006-11-23

申请号：US10557479

申请日：2004-05-20

申请人： George Siber

发明人： George Siber

IPC分类号： C12Q1/68 ,  C12P21/06

CPC分类号： C07K16/241 ,  A61K31/454 ,  A61K38/1793 ,  A61K2039/505

摘要： Compositions and methods for treating Severe Acute Respiratory Syndrome (SARS) are disclosed herein. Inhibitors of SARS-associated inflammatory cytokines are provided herein for use in treating SARS, including SARS-associated coronavirus (SARS-CoV) infection. Inhibitors of TNF are disclosed herein, as is the use of said inhibitors for treating SARS, including SARS-CoV. Methods of identifying and screening for said inhibitors are also provided.

摘要翻译： 本文公开了治疗严重急性呼吸综合征（SARS）的组合物和方法。 本文提供了SARS相关炎症细胞因子的抑制剂，用于治疗SARS，包括SARS相关冠状病毒（SARS-CoV）感染。 本文公开了TNF的抑制剂，以及所述抑制剂用于治疗SARS（包括SARS-CoV）的用途。 还提供了鉴定和筛选所述抑制剂的方法。