公开(公告)号：US4834974A

公开(公告)日：1989-05-30

申请号：US946435

申请日：1986-12-24

申请人： Gerald H. Stott ,  David O. Lucas

发明人： Gerald H. Stott ,  David O. Lucas

IPC分类号： A61K39/00 ,  A23C9/142 ,  A23J1/20 ,  A23K1/18 ,  A61K39/395 ,  A61P37/04 ,  C07K14/435 ,  C07K16/00 ,  C07K16/04

CPC分类号： A23C9/1425 ,  A23J1/205 ,  A23K50/60 ,  C07K16/04 ,  A23V2002/00 ,  Y10S530/833

摘要： A dry, immunologically active filtered product is produced through the controlled one or two stage ultrafiltration of liquid whey containing immunologically active immunoglobulin (Ig). When a predetermined quantity of the filtered product with an active Ig concentration of at least about seven percent of total solids is fed to newborn calves, the product functions as a substitute for natural colostrum, providing both temporary passive immunity as well as initiation of the active immune system of the animal. Disease resistance and growth rate in animals including humans is enhanced by oral administration of the filtered product. The immunological properties of the filtered product result from the presence of substantially enhanced concentrations of active Ig as well as other immunologically active whey components in comparison to the immunologically ineffective concentrations of these materials in the liquid whey ultrafiltration feedstock.

公开(公告)号：US4816252A

公开(公告)日：1989-03-28

申请号：US818610

申请日：1986-01-13

申请人： Gerald H. Stott ,  Dave Lucas

发明人： Gerald H. Stott ,  Dave Lucas

IPC分类号： A23C9/142 ,  A23J1/20 ,  A23K1/18 ,  C07K16/04 ,  A61K39/395 ,  A61K35/20

CPC分类号： A23C9/1425 ,  A23J1/205 ,  A23K50/60 ,  C07K16/04 ,  A23V2002/00 ,  Y10S530/833

摘要： The present invention relates to a product and process for assuring the transfer of adequate passive immunity to newborn domestic animals. Immunologically active immunoglobulins are extracted from the whey byproduct of dairy manufacturing by using ultrafiltration techniques to separate the large immuoglobulin molecules from the whey. The ultrafiltration retentate is dried to produce a filtered product having a high concentration of immunoglobulins. The dry filtered product is assayed to verify the immunological activity of the product and to measure the distribution and concentration of pathogen specific antibodies. The dry filtered product is stored. Subsequently, a dose of the product containing at least a minimum weight ratio of immunologically active Ig is fed to the newborn animal to transfer passive immunity. Ion exchange techniques can be combined with ultrafiltration techniques to significantly increase the Ig concentration in the ultimate product while simultanously reducing the net cost of producing the product. They whey-derived product may also be used on a continuous basis as a food supplement for an animal to enable the immunologically active immunoglobulin molecules in the product to attack pathogens present in the digestive system of the animal.

摘要翻译： 本发明涉及一种确保向新生儿家畜转移足够的被动免疫的产品和方法。 通过使用超滤技术从乳制品的乳清副产物中提取免疫活性的免疫球蛋白以从乳清中分离出大的免疫球蛋白分子。 将超滤保留物干燥以产生具有高浓度免疫球蛋白的过滤产物。 测定干燥过滤的产物以验证产物的免疫活性并测量病原体特异性抗体的分布和浓度。 储存干燥过滤的产品。 随后，将含有至少最小重量比的免疫活性Ig的产品的剂量喂给新生动物以转移被动免疫。 离子交换技术可以与超滤技术结合，以显着提高最终产品中的Ig浓度，同时降低生产产品的净成本。 它们的乳清衍生产品也可以连续使用作为动物的食物补充物，以使产品中免疫活性的免疫球蛋白分子能够攻击存在于动物消化系统中的病原体。

公开(公告)号：US5198213A

公开(公告)日：1993-03-30

申请号：US777194

申请日：1991-10-16

申请人： Gerald H. Stott ,  David O. Lucas

发明人： Gerald H. Stott ,  David O. Lucas

IPC分类号： A23C9/142 ,  A23J1/20 ,  A23K1/18 ,  C07K16/04

CPC分类号： A23C9/1425 ,  A23J1/205 ,  A23K50/60 ,  C07K16/04 ,  A23V2002/00 ,  Y10S530/833

摘要： Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.

摘要翻译： 来自普通乳的乳清包括包含乳糖和矿物质的底部馏分，包含较低分子量蛋白质的中间馏分和包含较高分子量蛋白质的顶部馏分。 顶部乳清组分包含可测量但低水平的免疫活性免疫球蛋白加其他病原体特异性抗体浓度。 通过一个或多个不同的方法步骤对乳清进行超滤，以产生具有至少约7％的总固体的免疫活性免疫球蛋白浓度的过滤产物。 定期测试过滤产品，以验证其对指定微生物的活性。 过滤产物以治疗有效剂量口服施用于动物以治疗疾病。

公开(公告)号：US5066491A

公开(公告)日：1991-11-19

申请号：US306817

申请日：1989-02-03

申请人： Gerald H. Stott ,  David O. Lucas

发明人： Gerald H. Stott ,  David O. Lucas

IPC分类号： A23C9/142 ,  A23J1/20 ,  A23K1/18 ,  C07K16/04 ,  A61K39/395

CPC分类号： C07K16/04 ,  A23C9/1425 ,  A23J1/205 ,  A23K50/60 ,  A23V2002/00 ,  Y10S530/833

摘要： Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.

摘要翻译： 来自普通乳的乳清包括包含乳糖和矿物质的底部馏分，包含较低分子量蛋白质的中间馏分和包含较高分子量蛋白质的顶部馏分。 顶部乳清组分包含可测量但低水平的免疫活性免疫球蛋白加其他病原体特异性抗体浓度。 通过一个或多个不同的方法步骤对乳清进行超滤，以产生具有至少约7％的总固体的免疫活性免疫球蛋白浓度的过滤产物。 定期测试过滤产品，以验证其对指定微生物的活性。 过滤产物以治疗有效剂量口服施用于动物以治疗疾病。