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    Protein hydrolysates and method of making
    1.
    发明授权
    Protein hydrolysates and method of making 有权
    蛋白质水解物及其制备方法

    公开(公告)号：US08101377B2

    公开(公告)日：2012-01-24

    申请号：US11619957

    申请日：2007-01-04

    申请人： Madison V. Blanton ,  Richard K. Merrill ,  Shannan E. Guck

    发明人： Madison V. Blanton ,  Richard K. Merrill ,  Shannan E. Guck

    IPC分类号： C12P21/06

    CPC分类号： C12P21/06 ,  A23G1/44 ,  A23G3/44 ,  A23G9/38 ,  A23J3/34 ,  A23L33/18 ,  Y10S530/832 ,  Y10S530/833

    摘要： Methods of making protein hydrolysates are described. The methods may include the steps of providing a solution comprising protein, and adjusting a pH of the solution to about 10.4 or more to form a basic protein solution. Additional steps may include adding a protease enzyme to the basic protein solution that converts at least a portion of the protein to protein hydrolysates. Protein hydrolysate compositions and water-soluble food additives are also described. The additives may include a mixture of protein hydrolysates formed by protein hydrolysis of a protein substrate. The protein hydrolysates may have an average molecular weight of about 2000 to about 10,000 Daltons.

    摘要翻译： 描述制备蛋白质水解产物的方法。 所述方法可以包括以下步骤：提供包含蛋白质的溶液，并将溶液的pH调节至约10.4或更大以形成碱性蛋白质溶液。 另外的步骤可以包括将蛋白酶添加到将至少一部分蛋白质转化为蛋白质水解产物的碱性蛋白质溶液中。 还描述了蛋白质水解物组合物和水溶性食品添加剂。 添加剂可以包括通过蛋白质底物的蛋白质水解形成的蛋白质水解产物的混合物。 蛋白质水解产物的平均分子量可以为约2000至约10,000道尔顿。

    Preparation of an aggregate whey protein product and its use
    2.
    发明授权
    Preparation of an aggregate whey protein product and its use 失效
    制备聚集乳清蛋白产品及其用途

    公开(公告)号：US06767575B1

    公开(公告)日：2004-07-27

    申请号：US09913548

    申请日：2001-10-01

    申请人： Manfred Huss ,  Thomas Spiegel

    发明人： Manfred Huss ,  Thomas Spiegel

    IPC分类号： A23J308

    CPC分类号： A23G9/40 ,  A23C19/082 ,  A23G9/52 ,  A23G2200/12 ,  A23J3/08 ,  A23P30/40 ,  A23V2002/00 ,  Y10S530/833 ,  A23V2300/08

    摘要： The invention relates to a method for preparing a concentrate of denatured whey protein aggregate preferably having a mean aggregate size (median) of between 1 and 4 &mgr;m. Said method consists of the following steps: a) an aqueous solution enriched to a maximum protein content of 4% by weight, containing whey protein and having a pH of between 5.0 and 7.0 is thermally denatured to [≦80%] ≦90%, in relation to the protein content, under substantially non-shear conditions at a temperature of between 75 and 150° C. and by means of a holding period; and b) the resulting product is concentrated, preferably to a denatured whey protein concentration of between 5 and 20%.

    摘要翻译： 本发明涉及一种制备变性乳清蛋白质聚集体浓缩物的方法，优选其平均骨料尺寸（中值）为1至4μm。 所述方法包括以下步骤：a）将含有4重量％的最大蛋白质含量的富含蛋白质含量的水溶液（含有乳清蛋白质，pH为5.0-7.0）热变性至[<= 80％] <= 90 在相对于蛋白质含量的情况下，在基本上非剪切条件下，在75至150℃的温度和通过保持期间之间; 和b）将所得产物浓缩，优选至5至20％的变性乳清蛋白浓度。

    Peptide mixture and products thereof
    3.
    发明授权
    Peptide mixture and products thereof 失效
    肽混合物及其产物

    公开(公告)号：US06395508B1

    公开(公告)日：2002-05-28

    申请号：US09316957

    申请日：1999-05-24

    申请人： Seiichi Shimamura ,  Yoshitaka Tamura ,  Hiroshi Miyakawa ,  Hitoshi Saito ,  Yasushi Kawaguchi ,  Naoko Isomura ,  Yoko Akazome ,  Hiroshi Ochi ,  Mihoko Kawamoto

    发明人： Seiichi Shimamura ,  Yoshitaka Tamura ,  Hiroshi Miyakawa ,  Hitoshi Saito ,  Yasushi Kawaguchi ,  Naoko Isomura ,  Yoko Akazome ,  Hiroshi Ochi ,  Mihoko Kawamoto

    IPC分类号： A23C2102

    CPC分类号： A61K38/018 ,  A23J3/08 ,  A23J3/343 ,  A23L33/18 ,  A61K38/01 ,  Y10S530/833

    摘要： A method for producing a peptide mixture from a starting protein by (1) adding at least one protease to an aqueous solution of at least one starting protein to hydrolyse the starting protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the starting protein, (3) calculating the amount of the free amino acid with respect to the total amount of amino acid contained in the starting protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the starting protein falls within a predetermined range. The inventive method provides a starting protein hydrolysate of uniform and consistent quality.

    摘要翻译： （1）在至少一种起始蛋白质的水溶液中加入至少一种蛋白酶以水解起始蛋白质的方法，从起始蛋白质制备肽混合物的方法，（2）测量游离氨基酸的量 在起始蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸组成的组，（3）计算游离氨基酸相对于起始蛋白质中所含氨基酸总量的量，以及（4）终止 当游离氨基酸的计算量相对于起始蛋白质中含有的氨基酸总量的计算量落在预定范围内时，水解。 本发明的方法提供均匀且一致质量的起始蛋白质水解产物。

    Biologically active whey protein concentrate
    6.
    发明授权
    Biologically active whey protein concentrate 失效
    生物活性乳清蛋白浓缩物

    公开(公告)号：US5290571A

    公开(公告)日：1994-03-01

    申请号：US417246

    申请日：1989-10-04

    申请人： Gustavo Bounous ,  Phil Gold ,  Patricia A. L. Kongshavn

    发明人： Gustavo Bounous ,  Phil Gold ,  Patricia A. L. Kongshavn

    IPC分类号： A23L1/305 ,  A61K35/20 ,  A61K38/17 ,  A61K39/395 ,  A61P31/04 ,  A61P37/00 ,  A61P43/00

    CPC分类号： A61K38/17 ,  A23L33/19 ,  A61K35/20 ,  A23V2002/00 ,  Y10S514/885 ,  Y10S530/833

    摘要： The present invention is concerned with a whey protein composition comprising a suitable concentration of whey protein concentrate wherein the whey protein concentrate contains proteins which are present in an essentially undenatured state and wherein the biological activity of the whey protein concentrate is dependent on the overall amino acid and small peptides pattern resulting from the contribution of all its protein components and a method of producing said whey protein composition. The invention also relates to several applications of said composition.

    摘要翻译： 本发明涉及包含适当浓度的乳清蛋白浓缩物的乳清蛋白组合物，其中乳清蛋白浓缩物含有基本上未变性状态的蛋白质，其中乳清蛋白浓缩物的生物学活性取决于总体氨基酸 以及由其所有蛋白质组分的贡献产生的小肽图案以及产生所述乳清蛋白组合物的方法。 本发明还涉及所述组合物的几种应用。

    Method of disease treatment utilizing an immunologically active whey fraction
    8.
    发明授权
    Method of disease treatment utilizing an immunologically active whey fraction 失效
    利用免疫活性乳清部分进行疾病治疗的方法

    公开(公告)号：US5066491A

    公开(公告)日：1991-11-19

    申请号：US306817

    申请日：1989-02-03

    申请人： Gerald H. Stott ,  David O. Lucas

    发明人： Gerald H. Stott ,  David O. Lucas

    IPC分类号： A23C9/142 ,  A23J1/20 ,  A23K1/18 ,  C07K16/04 ,  A61K39/395

    CPC分类号： C07K16/04 ,  A23C9/1425 ,  A23J1/205 ,  A23K50/60 ,  A23V2002/00 ,  Y10S530/833

    摘要： Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.

    摘要翻译： 来自普通乳的乳清包括包含乳糖和矿物质的底部馏分，包含较低分子量蛋白质的中间馏分和包含较高分子量蛋白质的顶部馏分。 顶部乳清组分包含可测量但低水平的免疫活性免疫球蛋白加其他病原体特异性抗体浓度。 通过一个或多个不同的方法步骤对乳清进行超滤，以产生具有至少约7％的总固体的免疫活性免疫球蛋白浓度的过滤产物。 定期测试过滤产品，以验证其对指定微生物的活性。 过滤产物以治疗有效剂量口服施用于动物以治疗疾病。