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公开(公告)号：US20170071919A1
公开(公告)日：2017-03-16
申请号：US15156528
申请日：2016-05-17
申请人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： A61K31/44 , C07D213/81 , C07D405/12 , A61K31/443 , A61K31/4545 , A61K31/5377 , C07D241/26 , A61K31/444 , A61K31/4439 , C07D413/04 , C07D413/12 , C07D403/12 , A61K31/497 , C07D401/04 , C07D405/04 , A61K45/06
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20150045364A1
公开(公告)日：2015-02-12
申请号：US14521843
申请日：2014-10-23
申请人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： C07D405/04 , A61K45/06 , C07D401/04 , A61K31/444 , A61K31/44 , C07D241/28 , A61K31/5377 , C07D403/12 , A61K31/497 , A61K31/4412 , C07D213/81 , A61K31/4439
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US20140135329A1
公开(公告)日：2014-05-15
申请号：US13923349
申请日：2013-06-20
申请人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
发明人： Urs BAETTIG , Kamlesh BALA , Emma BUDD , Lee EDWARDS , Catherine HOWSHAM , Glyn Alan HUGHES , Darren Mark LEGRAND , Katrin SPIEGEL
IPC分类号： C07D413/12 , C07D403/12 , A61K31/4965 , A61K31/4545 , A61K31/444 , A61K31/443 , A61K31/4439 , A61K31/44 , C07D241/28 , C07D401/12 , C07D401/04 , C07D413/04 , C07D405/12 , C07D213/81 , C07D213/38 , A61K31/497 , A61K31/5377
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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公开(公告)号：US08476269B2
公开(公告)日：2013-07-02
申请号：US13544182
申请日：2012-07-09
申请人： Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
发明人： Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
IPC分类号： A61K31/5355 , A61K31/497 , A61K31/4965 , A61K31/4453 , A61K31/454 , A61K31/443 , A61K31/444 , A61K31/445 , C07D213/22 , C07D213/26 , C07D211/06 , C07D413/12 , C07D213/61 , C07D213/04 , C07D241/16
CPC分类号： A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4965 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/38 , C07D213/81 , C07D241/26 , C07D241/28 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供吡啶和吡嗪衍生物，其恢复或增强突变和/或野生型CFTR的功能以治疗囊性纤维化，原发性纤毛运动障碍，慢性支气管炎，慢性阻塞性肺病，哮喘，呼吸道感染，肺癌，口腔干燥症和 角膜结膜炎或便秘（IBS，IBD，阿片样物质诱发）。 还包括包含这些衍生物的药物组合物。
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