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    High bandwidth steering mirror
    2.
    发明授权
    High bandwidth steering mirror 失效
    高带宽导向镜

    公开(公告)号：US5110195A

    公开(公告)日：1992-05-05

    申请号：US670500

    申请日：1991-03-15

    申请人： Gregory C. Loney

    发明人： Gregory C. Loney

    IPC分类号： G02B7/182

    CPC分类号： G02B7/1827

    摘要： A steering mirror assembly operates in a stable manner with a high bandwidth, with one to two degree peak-to-peak angular stroke. The steering mirror assembly includes a mirror for directing signals to their destination by reflection. The steering mirror may be moved through any position in a cone of several degrees. Movement of the mirror is achieved by a number of actuators. The mirror is coupled to a flexure ring that locks out undesirable directions of motion. The mirror assembly also includes position sensor that indicate to the assembly where the mirror is currently positioned. Data from these sensors is used as feedback to appropriately adjust mirror position.

    摘要翻译： 转向镜组件以高带宽稳定的方式工作，具有一到二度的峰 - 峰角行程。 转向镜组件包括用于通过反射将信号引导到其目的地的反射镜。 转向镜可以移动通过几度锥形的任何位置。 反射镜的运动通过许多致动器实现。 镜子耦合到锁定不期望的运动方向的挠曲环。 反射镜组件还包括位置传感器，其向组件指示反射镜当前所在的位置。 来自这些传感器的数据用作反馈以适当地调整镜子位置。

    Method and device for slide caching
    3.
    发明授权
    Method and device for slide caching 有权
    幻灯片缓存的方法和设备

    公开(公告)号：US09036255B2

    公开(公告)日：2015-05-19

    申请号：US13444141

    申请日：2012-04-11

    申请人： Gregory C. Loney ,  Glenn Stark ,  Chris Todd ,  Bikash Sabata

    发明人： Gregory C. Loney ,  Glenn Stark ,  Chris Todd ,  Bikash Sabata

    IPC分类号： G02B21/26 ,  H04N7/18 ,  G02B21/24

    CPC分类号： G02B21/0036 ,  G01N1/312 ,  G01N35/0099 ,  G01N2035/00049 ,  G01N2035/00138 ,  G01N2035/0441 ,  G01N2035/0462 ,  G01N2035/0493 ,  G02B21/002 ,  G02B21/006 ,  G02B21/245 ,  G02B21/26 ,  G02B21/361

    摘要： Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.

    摘要翻译： 用于光学扫描显微镜和/或其他适当成像系统的系统和技术包括用于扫描和收集组织样品和/或设置在载片上的其它物体的聚焦图像的组件。 本文描述的聚焦系统提供了捕获快照时确定每个快照的最佳聚焦，其可以被称为“即时聚焦”。本文提供的装置和技术导致形成所需时间的显着减少 病理学幻灯片中的区域的数字图像，并且以高产量提供样品的高质量数字图像。

    FOCUS AND IMAGING SYSTEM AND TECHNIQUES USING ERROR SIGNAL
    4.
    发明申请
    FOCUS AND IMAGING SYSTEM AND TECHNIQUES USING ERROR SIGNAL 审中-公开
    使用错误信号的焦点和成像系统和技术

    公开(公告)号：US20140204196A1

    公开(公告)日：2014-07-24

    申请号：US14237050

    申请日：2012-08-21

    申请人： Gregory C. Loney ,  Glenn Stark

    发明人： Gregory C. Loney ,  Glenn Stark

    IPC分类号： A61B1/00

    CPC分类号： A61B1/00188 ,  G02B7/38 ,  G02B21/245

    摘要： Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” Best focus may be determined using an error function generated according to movement of a dither focusing lens. The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.

    摘要翻译： 用于光学扫描显微镜和/或其他适当成像系统的系统和技术包括用于扫描和收集组织样品和/或设置在载片上的其它物体的聚焦图像的组件。 本文描述的聚焦系统提供了确定拍摄快照时的每个快照的最佳聚焦，其可被称为“即时聚焦”。可以使用根据抖动的移动产生的误差函数来确定最佳焦点 聚焦镜头 这里提供的装置和技术导致形成病理载片中的区域的数字图像所需的时间的显着减少，并且以高产量提供样品的高质量数字图像的创建。

    IMAGING SYSTEMS, CASSETTES, AND METHODS OF USING THE SAME
    5.
    发明申请
    IMAGING SYSTEMS, CASSETTES, AND METHODS OF USING THE SAME 审中-公开
    成像系统，CASSETTES及其使用方法

    公开(公告)号：US20140178169A1

    公开(公告)日：2014-06-26

    申请号：US14236667

    申请日：2012-08-21

    申请人： Raphael Hebert ,  Gregory C. Loney ,  Keith Moravick ,  David Moriconi ,  Christopher Eugene Todd

    发明人： Raphael Hebert ,  Gregory C. Loney ,  Keith Moravick ,  David Moriconi ,  Christopher Eugene Todd

    IPC分类号： G01N35/02 ,  G02B21/34

    CPC分类号： G01N35/025 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/143 ,  B01L2200/18 ,  B01L2300/021 ,  B01L2300/0822 ,  B01L2300/0841 ,  G02B21/24 ,  G02B21/34

    摘要： A microscope slide holding cassette includes a main body for surrounding and protecting microscopes, and shelves capable of holding the microscope slides. The shelves have support members that extend outwardly in order to support label ends of slides. Catches carried at the end of the support members are capable of limiting movement of the slides during transport of the cassette. To transport slides to different workstations, a pickup device can use a vacuum to pick up a slide without contacting areas of the slide that may have glue. The pickup device can load and unload the cassette. The pickup device can have a low-profile configuration in order to access relatively small spaces for processing flexibility.

    摘要翻译： 显微镜载片盒包括用于包围和保护显微镜的主体，以及能够保持显微镜幻灯片的搁板。 搁架具有向外延伸的支撑构件，以支撑滑块的标签端。 在支撑构件的端部承载的抓持器能够限制在盒的传送期间滑块的移动。 为了将幻灯片运送到不同的工作站，拾取装置可以使用真空来拾取滑动件而不接触可能具有胶水的滑块的区域。 拾取装置可以装载和卸载盒式磁带。 拾取装置可以具有薄型结构，以便访问相对较小的空间以便处理灵​​活性。

    Method of Detection of Fluorescence-Labeled Probes Attached to Diseased Solid Tissue
    7.
    发明申请
    Method of Detection of Fluorescence-Labeled Probes Attached to Diseased Solid Tissue 审中-公开
    荧光标记探针附着在病态固体组织上的检测方法

    公开(公告)号：US20100226926A1

    公开(公告)日：2010-09-09

    申请号：US12720582

    申请日：2010-03-09

    申请人： Gregory C. Loney ,  Vikram Mohan ,  Rob Monroe ,  Bikash Sabata ,  Glenn Stark

    发明人： Gregory C. Loney ,  Vikram Mohan ,  Rob Monroe ,  Bikash Sabata ,  Glenn Stark

    IPC分类号： A61K39/395 ,  C12Q1/68

    CPC分类号： C12Q1/6813

    摘要： Disclosed herein, in certain embodiments, is a method of treating breast cancer characterized by the amplification of HER2 genes in a subject in need thereof, comprising: (a) isolating a tissue sample comprised of a plurality of breast tumor cells; (b) isolating a first section from said tissue sample; (c) isolating a second section from an adjacent portion of said tissue sample; (d) contacting the first section with a first stain; (e) contacting the second section with a probe; (f) imaging the first section following contact with the stain to produce a first image; (g) analyzing the first image for abnormal microscopic features; (h) identifying areas of interest in the first image that display abnormal microscopic features; (i) electronically annotating the first image to identify the areas of interest; (j) imaging the second section following contact with the probe; (k) aligning the first image and the second image; and (l) analyzing areas of interest in the second image that correspond to an area of interest identified in the first image; wherein the subject is administered an anti-HER2 antibody if HER2 is amplified or providing an alternative treatment if HER2 is not amplified.

    摘要翻译： 在某些实施方案中，本文公开了一种治疗乳腺癌的方法，其特征在于在有需要的受试者中扩增HER2基因，其包括：（a）分离由多个乳腺肿瘤细胞组成的组织样品; （b）从所述组织样品中分离第一部分; （c）从所述组织样本的相邻部分分离第二部分; （d）使第一部分与第一染料接触; （e）使第二部分与探针接触; （f）在与染色剂接触之后成像第一部分以产生第一图像; （g）分析第一图像的异常显微特征; （h）识别显示异常微观特征的第一图像中的感兴趣区域; （i）以电子方式注释第一张图片以确定感兴趣的区域; （j）在与探针接触之后成像第二部分; （k）对准所述第一图像和所述第二图像; 和（l）分析对应于在第一图像中标识的兴趣区域的第二图像中的感兴趣区域; 其中如果HER2被扩增，则所述受试者被施用抗HER2抗体，或者如果HER2不被扩增则提供替代治疗。