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21 条记录 (耗时 0.036 秒)

    Oxime and Hydroxylamine Substituted Thiazolo [4,5-C] Ring Compounds and Methods
    4.
    发明申请
    Oxime and Hydroxylamine Substituted Thiazolo [4,5-C] Ring Compounds and Methods 失效
    肟和羟胺取代的噻唑并[4,5-C]环化合物和方法

    公开(公告)号：US20100240693A1

    公开(公告)日：2010-09-23

    申请号：US11884060

    申请日：2006-02-08

    申请人： Gregory D. Lundquist, JR. ,  Tushar M. Kshirsagar ,  Philip D. Heppner

    发明人： Gregory D. Lundquist, JR. ,  Tushar M. Kshirsagar ,  Philip D. Heppner

    IPC分类号： A61K31/437 ,  C07D513/04 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07D513/04

    摘要： Thiazolo[4,5-c]ring compounds, (e.g. thiazolopyridine, thiazoloquinoline, 6,7,8,9-tetrahydrothiazoloquinoline, thiazolonaphthyridine, and 6,7,8,9-tetrahydrothiazolonaphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 噻唑并[4,5-c]环化合物（例如噻唑并吡啶，噻唑并喹啉，6,7,8,9-四氢噻唑并喹啉，噻唑烷萘啶和6,7,8,9-四氢噻唑并萘啶化合物）在2位具有肟或羟胺取代基 公开了含有化合物的药物组合物，中间体和制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

    Pyrazolopyridine-1,4-Diamines and Analogs Thereof
    6.
    发明申请
    Pyrazolopyridine-1,4-Diamines and Analogs Thereof 有权
    吡唑并吡啶-1,4-二胺及其类似物

    公开(公告)号：US20090124611A1

    公开(公告)日：2009-05-14

    申请号：US11887524

    申请日：2006-03-31

    申请人： David S. Hays ,  Shri Niwas ,  Gregory D. Lundquist Jr.

    发明人： David S. Hays ,  Shri Niwas ,  Gregory D. Lundquist Jr.

    IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/5377 ,  A61P31/12 ,  A61P35/00

    CPC分类号： C07D471/04

    摘要： Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4-c]pyridine-1,4-diamines, pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, and pyrazolo[3,4-c]naphthyridine-1,4-di-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

    摘要翻译： 吡唑并吡喃-1,4-二胺及其类似物，例如吡唑并[3,4-c]吡啶-1,4-二胺，吡唑并[3,4-c]喹啉-1,4-二胺，6,7,8 ，9-四氢吡唑并[3,4-c]喹啉-1,4-二胺和吡唑并[3,4-c]二氮杂萘-1,4-二胺，含有这些化合物的药物组合物，中间体，制备方法 公开了这些化合物以及这些化合物作为免疫调节剂用于诱导动物中细胞因子生物合成和治疗包括病毒和肿瘤疾病的疾病的方法。