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公开(公告)号:US09880322B2
公开(公告)日:2018-01-30
申请号:US13985058
申请日:2012-04-25
IPC分类号: G02B1/04 , C08F220/18 , C08J7/16 , C09D133/06
CPC分类号: G02B1/04 , C08F220/18 , C08J7/16 , C09D133/06
摘要: Presently described are optical films comprising a polymerized (e.g. microstructured) surface that comprises the reaction product of a polymerizable resin composition and polymerizable resin compositions that comprise nanoparticles; at least one first monomer comprising at least two (meth)acrylate groups; and at least one second (meth)acrylate monomer having following the structure (I); wherein at least one R1 comprises an aromatic substituent, t is an integer from 1 to 4, and R2 is hydrogen or methyl.
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公开(公告)号:US08846710B2
公开(公告)日:2014-09-30
申请号:US11884982
申请日:2006-02-22
申请人: Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
发明人: Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
IPC分类号: A61K31/4745 , C07D471/04 , C07D471/14
CPC分类号: A61K31/4745 , C07D471/04 , C07D471/14 , Y02A50/409 , Y02A50/411 , Y02A50/481
摘要: A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.
摘要翻译: 一种在动物中优先诱导IFN-α生物合成的方法,其包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物,中间体,制备方法和 公开了使用这些化合物的免疫调节剂用于治疗包括病毒和肿瘤疾病在内的疾病的方法,其包括在动物中优先诱导IFN-α生物合成。
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公开(公告)号:US20130038939A1
公开(公告)日:2013-02-14
申请号:US13639902
申请日:2011-05-03
申请人: Christopher B. Walker, JR. , Christopher P. Tebow , Tri D. Pham , Steven H. Kong , Joseph T. Aronson , Kyle J. Lindstrom , Michael K. Gerlach , Michelle L. Toy , Taun L. McKenzie , Anthony M. Renstrom , Robert A. Yapel , Mitchell A.F. Johnson
发明人: Christopher B. Walker, JR. , Christopher P. Tebow , Tri D. Pham , Steven H. Kong , Joseph T. Aronson , Kyle J. Lindstrom , Michael K. Gerlach , Michelle L. Toy , Taun L. McKenzie , Anthony M. Renstrom , Robert A. Yapel , Mitchell A.F. Johnson
IPC分类号: G02B1/11
CPC分类号: G02B1/118 , G02B5/0242
摘要: The present invention concerns antireflective films comprising a high refractive index layer (60) and low refractive index layer (80) disposed on the high refractive index layer. The antireflective films have a microstructured surface (70) that can be derived from a microreplicated tool.
摘要翻译: 本发明涉及包括设置在高折射率层上的高折射率层(60)和低折射率层(80)的抗反射膜。 抗反射膜具有可从微复制工具衍生的微结构化表面(70)。
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公开(公告)号:US08080608B2
公开(公告)日:2011-12-20
申请号:US12936552
申请日:2009-05-19
申请人: Bryan V. Hunt , Kyle J. Lindstrom , James P. DiZio
发明人: Bryan V. Hunt , Kyle J. Lindstrom , James P. DiZio
CPC分类号: C08F220/40 , B29K2033/12 , Y10S977/773
摘要: Presently described are (e.g. microstructured) optical films and polymerizable resin compositions comprising at least one (meth)acrylate monomer comprising an unsubstituted or substituted phenyl ethylene group referred to as phenyl ethylene (meth)acrylate monomers.
摘要翻译: 目前描述的是(例如微结构的)光学薄膜和包含至少一种(甲基)丙烯酸酯单体的可聚合树脂组合物,所述单体包含被称为苯乙烯(甲基)丙烯酸酯单体的未取代或取代的苯基亚乙基。
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公开(公告)号:US07897597B2
公开(公告)日:2011-03-01
申请号:US10595103
申请日:2004-08-27
申请人: Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Tushar A. Kshirsagar , Philip D. Heppner , Shri Niwas , George W. Griesgraber , Matthew R. Radmer
发明人: Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Tushar A. Kshirsagar , Philip D. Heppner , Shri Niwas , George W. Griesgraber , Matthew R. Radmer
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译: 在6,7,8或9位含有芳氧基或芳基亚烷基氧基或羟基取代基的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物,中间体和使用方法,用于调节动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。
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公开(公告)号:US07678918B2
公开(公告)日:2010-03-16
申请号:US11999602
申请日:2007-12-06
申请人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号: C07D411/02
CPC分类号: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
摘要翻译: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号:US20090023722A1
公开(公告)日:2009-01-22
申请号:US12165014
申请日:2008-06-30
申请人: Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人: Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号: A61K31/5377 , A61K31/437 , A61K31/496 , A61P35/00 , A61P31/12
CPC分类号: C07D471/04 , A61K31/4745
摘要: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译: 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成,并且可用于治疗各种病症,包括病毒性疾病和肿瘤性疾病。
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公开(公告)号:US07199131B2
公开(公告)日:2007-04-03
申请号:US11101369
申请日:2005-04-07
申请人: Kyle J. Lindstrom
发明人: Kyle J. Lindstrom
IPC分类号: A61K31/44
CPC分类号: A61K31/4745 , C07D471/04 , Y02A50/409
摘要: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译: 在1位含有磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫反应调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成,并且可用于治疗各种病症,包括病毒性疾病和肿瘤性疾病。
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公开(公告)号:US07125890B2
公开(公告)日:2006-10-24
申请号:US10916125
申请日:2004-08-11
申请人: Joseph F. Dellaria , Kyle J. Lindstrom , Luke T. Dressel , Daniel E. Duffy , Philip D. Heppner , John R. Jacobsen , Joan T. Moseman , William H. Moser , Matthew R. Radmer , Doris Stoermer , Bernhard M. Zimmermann
发明人: Joseph F. Dellaria , Kyle J. Lindstrom , Luke T. Dressel , Daniel E. Duffy , Philip D. Heppner , John R. Jacobsen , Joan T. Moseman , William H. Moser , Matthew R. Radmer , Doris Stoermer , Bernhard M. Zimmermann
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04
摘要: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译: 在1位含有醚或硫醚官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成,并且可用于治疗各种病症,包括病毒性疾病和肿瘤性疾病。 还公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号:US06969722B2
公开(公告)日:2005-11-29
申请号:US10772170
申请日:2004-02-04
IPC分类号: A61K31/4745 , C07D471/02 , C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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