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    Percussion hammer bit retainer apparatus
    1.
    发明授权
    Percussion hammer bit retainer apparatus 有权
    打击乐锤钻头保持架

    公开(公告)号：US07117939B1

    公开(公告)日：2006-10-10

    申请号：US10718167

    申请日：2003-11-20

    Applicant: Gregory Dee Hawley ,  John Adam Meyers

    Inventor： Gregory Dee Hawley ,  John Adam Meyers

    IPC: E21B31/18

    CPC classification number: E21B10/36 ,  E21B17/076

    Abstract: A bit retention apparatus for the use of retrieving the hammer bit in cases of shankage. The apparatus incorporates a dual sleeve design that fits over the chuck and the extended head section of the hammer bit. The first, “inner” sleeve has two or more ring pieces that fit onto the chuck and have the retention ring fitted into the lower section of the sleeve. The second, “outer” sleeve fits onto the chuck over the inner sleeve to provide protect to the inner sleeve while pulling the shanked bit out of the well bore. Attachment to the bit is accomplished by collars, knobs, or threads on the interior of the sleeves that correspond with holding bands, retention rings, or threads on the bit and chuck.

    Abstract translation: 一种位置保持装置，用于在锤击的情况下检索锤头。 该装置包括一个双套筒设计，其配合在卡盘和锤头的扩展头部分之上。 第一个“内”套筒具有两个或更多个装在卡盘上的环件，并且保持环安装在套筒的下部。 第二个“外部”套管装配在内套筒上的卡盘上，以将柄部钻头从井筒中拉出来，以保护内套筒。 与钻头和卡盘上的保持带，固定环或螺纹相对应的套筒内部的套环，旋钮或螺纹可以实现钻头附件。

    Method and system for DNA sequence determination and mutation detection
    3.
    发明授权
    Method and system for DNA sequence determination and mutation detection 失效
    用于DNA序列测定和突变检测的方法和系统

    公开(公告)号：US06303303B1

    公开(公告)日：2001-10-16

    申请号：US09190756

    申请日：1998-11-12

    Applicant: Ronald J. Green ,  Vrijmoed Chi ,  Rodney D. Gilchrist ,  Gregory Dee ,  John K. Stevens

    Inventor： Ronald J. Green ,  Vrijmoed Chi ,  Rodney D. Gilchrist ,  Gregory Dee ,  John K. Stevens

    IPC: C12Q168

    CPC classification number: G01N27/44721 ,  G01N27/44717 ,  G06F19/18 ,  G06F19/22 ,  Y10T436/143333

    Abstract: Normalization of experimental fragment patterns for nucleic acid polymers having putatively known sequences starts with obtaining at least one raw fragment pattern for the experimental sample. The raw fragment pattern represents the positions of a selected nucleic acid base within the polymer as a function of migration time or distance. This raw fragment pattern is conditioned using conventional baseline correction and noise reduction technique to yield a clean fragment pattern. The clean fragment pattern is then evaluated to determine one or more “normalization coefficients.” These normalization coefficients reflect the displacement, stretching or shrinking, and rate of stretching or shrinking of the clean fragment, or segments thereof, which are necessary to obtain a suitably high degree of correlation between the clean fragment pattern and a standard fragment pattern which represents the positions of the selected nucleic acid base within a standard polymer actually having the known sequence as a function of migration time or distance. The normalization coefficients are then applied to the clean fragment pattern to produce a normalized fragment pattern which is used for base-calling in a conventional manner. This method may be implemented in an apparatus comprising a computer processor programmed to determine normalization coefficients for an experimental fragment pattern. This computer may be separate from the electrophoresis apparatus, or part of an integrated unit.

    Abstract translation: 具有推定已知序列的核酸聚合物的实验片段模式的归一化从获得实验样品的至少一个原始片段图案开始。 原始片段图案表示聚合物内所选择的核酸碱基作为迁移时间或距离的函数的位置。 使用常规的基线校正和降噪技术调节该原始片段模式以产生干净的片段模式。 然后评估干净的片段模式以确定一个或多个“归一化系数”。 这些归一化系数反映了清洁片段或其片段的位移，拉伸或缩小以及拉伸或收缩速率，这些片段或片段是清洁片段图案与标示片段图案之间适当高程度的相关性所必需的， 实际上具有已知序列的标准聚合物内所选核酸碱基的位置作为迁移时间或距离的函数。 然后将归一化系数应用于干净的片段模式以产生用于以常规方式的基本呼叫的归一化的片段模式。 该方法可以在包括被编程为确定实验片段模式的归一化系数的计算机处理器的装置中实现。 该计算机可以与电泳装置或集成单元的一部分分开。

    Method and system for DNA sequence determination and mutation detection with reference to a standard
    4.
    发明授权
    Method and system for DNA sequence determination and mutation detection with reference to a standard 失效
    参考标准的DNA序列测定和突变检测的方法和系统

    公开(公告)号：US5853979A

    公开(公告)日：1998-12-29

    申请号：US497202

    申请日：1995-06-30

    Applicant: Ronald J. Green ,  Vrijmoed Chi ,  Rodney D. Gilchrist ,  Gregory Dee ,  John K. Stevens

    Inventor： Ronald J. Green ,  Vrijmoed Chi ,  Rodney D. Gilchrist ,  Gregory Dee ,  John K. Stevens

    IPC: C12Q1/68 ,  G01N27/447 ,  C12Q1/70 ,  G01N33/48 ,  G06K9/00

    CPC classification number: G01N27/44721 ,  G01N27/44717 ,  G06F19/18 ,  G06F19/22 ,  Y10T436/143333

    Abstract: Normalization of experimental fragment patterns for nucleic acid polymers having putatively known sequences starts with obtaining at least one raw fragment pattern for the experimental sample. The raw fragment pattern represents the positions of a selected nucleic acid base within the polymer as a function of migration time or distance. This raw fragment pattern is conditioned using conventional baseline correction and noise reduction technique to yield a clean fragment pattern. The clean fragment pattern is then evaluated to determine one or more "normalization coefficients." These normalization coefficients reflect the displacement, stretching or shrinking, and rate of stretching or shrinking of the clean fragment, or segments thereof, which are necessary to obtain a suitably high degree of correlation between the clean fragment pattern and a standard fragment pattern which represents the positions of the selected nucleic acid base within a standard polymer actually having the known sequence as a function of migration time or distance. The normalization coefficients are then applied to the clean fragment pattern to produce a normalized fragment pattern which is used for base-calling in a conventional manner. This method may be implemented in an apparatus comprising a computer processor programmed to determine normalization coefficients for an experimental fragment pattern. This computer may be separate from the electrophoresis apparatus, or part of an integrated unit.

    Abstract translation: 具有推定已知序列的核酸聚合物的实验片段模式的归一化从获得实验样品的至少一个原始片段图案开始。 原始片段图案表示聚合物内所选择的核酸碱基作为迁移时间或距离的函数的位置。 使用常规的基线校正和降噪技术调节该原始片段模式以产生干净的片段模式。 然后评估干净的片段模式以确定一个或多个“归一化系数”。 这些归一化系数反映了清洁片段或其片段的位移，拉伸或缩小以及拉伸或收缩速率，这些片段或片段是清洁片段图案与标示片段图案之间适当高程度的相关性所必需的， 实际上具有已知序列的标准聚合物内所选核酸碱基的位置作为迁移时间或距离的函数。 然后将归一化系数应用于干净的片段模式以产生用于以常规方式的基本呼叫的归一化的片段模式。 该方法可以在包括被编程为确定实验片段模式的归一化系数的计算机处理器的装置中实现。 该计算机可以与电泳装置或集成单元的一部分分开。

    Virtual DNA sequencer
    5.
    发明授权
    Virtual DNA sequencer 失效
    虚拟DNA测序仪

    公开(公告)号：US5776767A

    公开(公告)日：1998-07-07

    申请号：US570994

    申请日：1995-12-12

    Applicant: John K. Stevens ,  James M. Dunn ,  Gregory Dee ,  James W. Cassidy

    Inventor： John K. Stevens ,  James M. Dunn ,  Gregory Dee ,  James W. Cassidy

    IPC: G01N27/447 ,  G06F19/00 ,  C12M3/00

    CPC classification number: G01N27/44782

    Abstract: A virtual DNA sequencer combines a plurality of individual DNA sequencers. Samples of DNA or other nucleic acid from subjects are prepared and allocated in real time to particular lanes or sets of lanes in electrophoresis plates of the individual sequencers, with records kept of the allocations. The data resulting from the electrophoresis runs is collected and collated according to the identities of the subjects. The individual sequencers are networked, and each individual sequencer is preferably equipped with a data buffer large enough to accommodate all or substantially all of a data run, thus protecting the virtual sequencer from loss of valuable data in the event that the network is disrupted for some portion of the time of the data run. In this way, a plurality of sequencers is virtually the same as a single sequencer with a very large number of tracks each of which can run for a much longer sequencing run than an individual sequencer.

    Abstract translation: 虚拟DNA测序仪组合了多个单独的DNA测序仪。 来自受试者的DNA或其他核酸的样品被制备并实时分配到各个定序器的电泳板中的特定泳道或泳道组，并保存有分配记录。 根据受试者的身份收集和整理电泳运行产生的数据。 各个顺控程序被联网，并且每个单独的定序器优选地配备有足够大的数据缓冲器，以容纳所有或基本上所有的数据运行，从而在网络被中断的情况下保护虚拟定序器免于丢失有价值的数据 部分时间的数据运行。 以这种方式，多个定序器与具有非常大数量的轨道的单个定序器几乎相同，每个轨道可以运行比单个定序器更长的排序运行。

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