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公开(公告)号：US5059523A
公开(公告)日：1991-10-22
申请号：US189238
申请日：1988-05-02
申请人： Wolfgang J. Rettig , Pilar Garin-Chesa , H. Richard Beresford , Herbert F. Oettgen , Myron R. Melamed , Lloyd J. Old
发明人： Wolfgang J. Rettig , Pilar Garin-Chesa , H. Richard Beresford , Herbert F. Oettgen , Myron R. Melamed , Lloyd J. Old
CPC分类号： C07K16/28 , C07K16/30 , Y10S435/96 , Y10S436/813 , Y10S530/809
摘要： This invention provides a method of identifying mesenchymal tissues as normal, proliferatively active or malignant. This invention also provides a method of distinguishing subsets of sarcomas with distinctive antigenic phenotypes. This invention also provides a method of diagnosing mesenchymal tumors. Finally, this invention provides a monoclonal antibody designated G171 and the hybridoma cell line producing said monoclonal antibody (ATCC No. HB9254).
摘要翻译： 本发明提供了将间充质组织鉴定为正常，增殖活性或恶性的方法。 本发明还提供了区分具有特异性抗原表型的肉瘤子集的方法。 本发明还提供了诊断间充质肿瘤的方法。 最后，本发明提供了称为G171的单克隆抗体和产生所述单克隆抗体（ATCC No.HB9254）的杂交瘤细胞系。
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公开(公告)号：US4642291A
公开(公告)日：1987-02-10
申请号：US413861
申请日：1982-09-01
申请人： J. Gregory Cairncross , M. Jules Mattes , H. Richard Beresford , Anthony P. Albino , Alan N. Houghton , Kenneth O. Lloyd , Lloyd J. Old
发明人： J. Gregory Cairncross , M. Jules Mattes , H. Richard Beresford , Anthony P. Albino , Alan N. Houghton , Kenneth O. Lloyd , Lloyd J. Old
CPC分类号： C07K16/30 , Y10S435/948
摘要： Method of forming an antibody producing hybridoma cell line by fusing a myeloma cell line with splenocytes derived from BALB/c mice immunized with human astrocytoma tumor cells, the hybridoma cell line formed, and the monoclonal antibodies generated by said hybridoma cell line. A method of phenotyping astrocytoma tumor cells comprising determining the reaction of said cells to various monoclonal antibodies to astrocytoma tumor cells is also provided.
摘要翻译： 通过将骨髓瘤细胞系与源自用人星形细胞瘤肿瘤细胞免疫的BALB / c小鼠的脾细胞，形成的杂交瘤细胞系和由所述杂交瘤细胞系产生的单克隆抗体融合来形成产生抗体的杂交瘤细胞系的方法。 还提供了表型星形细胞瘤肿瘤细胞的方法，包括测定所述细胞与星形细胞瘤肿瘤细胞的各种单克隆抗体的反应。
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