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公开(公告)号:US4806628A
公开(公告)日:1989-02-21
申请号:US840632
申请日:1986-03-17
IPC分类号: A61K38/00 , A61K51/10 , C07K16/28 , C07K16/30 , G01N33/569 , G01N33/574 , G01N33/577 , C07K15/00 , C12N5/00
CPC分类号: G01N33/574 , A61K51/1066 , C07K16/28 , C07K16/3053 , G01N33/56966 , G01N33/577 , A61K2123/00 , A61K38/00 , Y10S530/808 , Y10S530/809
摘要: Monoclonal antibodies were discovered which recognize differentiation antigens on melanocytes and melanoma cells at various stages of differentiation. A system of classification based on these antigens is proposed and their use in the diagnosis and treatment of melanoma is given.
摘要翻译: 发现单克隆抗体在不同的分化阶段识别黑素细胞和黑素瘤细胞上的分化抗原。 提出了基于这些抗原的分类系统,并给出了它们在黑色素瘤诊断和治疗中的应用。
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公开(公告)号:US4642291A
公开(公告)日:1987-02-10
申请号:US413861
申请日:1982-09-01
申请人: J. Gregory Cairncross , M. Jules Mattes , H. Richard Beresford , Anthony P. Albino , Alan N. Houghton , Kenneth O. Lloyd , Lloyd J. Old
发明人: J. Gregory Cairncross , M. Jules Mattes , H. Richard Beresford , Anthony P. Albino , Alan N. Houghton , Kenneth O. Lloyd , Lloyd J. Old
CPC分类号: C07K16/30 , Y10S435/948
摘要: Method of forming an antibody producing hybridoma cell line by fusing a myeloma cell line with splenocytes derived from BALB/c mice immunized with human astrocytoma tumor cells, the hybridoma cell line formed, and the monoclonal antibodies generated by said hybridoma cell line. A method of phenotyping astrocytoma tumor cells comprising determining the reaction of said cells to various monoclonal antibodies to astrocytoma tumor cells is also provided.
摘要翻译: 通过将骨髓瘤细胞系与源自用人星形细胞瘤肿瘤细胞免疫的BALB / c小鼠的脾细胞,形成的杂交瘤细胞系和由所述杂交瘤细胞系产生的单克隆抗体融合来形成产生抗体的杂交瘤细胞系的方法。 还提供了表型星形细胞瘤肿瘤细胞的方法,包括测定所述细胞与星形细胞瘤肿瘤细胞的各种单克隆抗体的反应。
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