公开(公告)号：US20130150523A1

公开(公告)日：2013-06-13

申请号：US13703668

申请日：2012-09-07

申请人： Ang Xiao ,  Haibo Zhu ,  Sunghun Song ,  Wei Li ,  Zhiyong Liu

发明人： Ang Xiao ,  Haibo Zhu ,  Sunghun Song ,  Wei Li ,  Zhiyong Liu

IPC分类号： C09D179/08

CPC分类号： C09D179/08 ,  G02F1/133723 ,  G02F1/133784 ,  Y10T428/10 ,  Y10T428/1005 ,  Y10T428/1023

摘要： The invention provides a liquid crystal alignment film, a method for preparing the same and a liquid crystal display device comprising the same. The alignment film comprises polyimide obtained by reacting the compound as shown in Formula 2 or Formula 3 with the aromatic diamine as shown in Formula 1, wherein the R1, R2, R3, R4, R5, R6, R7, R1′, R2′, R3′, R4′, R5′, R6′, R7′, or R8′ substituent is H, alkyl, aralkyl or haloalkyl, and the Ar is aryl. The liquid crystal alignment film has a tactic spatial configuration, decreases the π-π attractive interaction between the polyimide backbones, allows the directional and homogenous alignment of the liquid crystal molecules on the surface of the polyimide, and thereby increases the contrast of the liquid crystal display.

摘要翻译： 本发明提供一种液晶取向膜，其制备方法和包含该液晶取向膜的液晶显示装置。 取向膜包括通过如式2或式3所示的化合物与式1所示的芳族二胺反应得到的聚酰亚胺，其中R1，R2，R3，R4，R5，R6，R7，R1'，R2'， R 3'，R 4'，R 5'，R 6'，R 7'或R 8'取代基是H，烷基，芳烷基或卤代烷基，Ar是芳基。 液晶取向膜具有策略空间结构，降低了聚酰亚胺主链之间的吸引力相互作用，允许液晶分子在聚酰亚胺表面上的定向和均匀取向，从而增加液晶的对比度 显示。

公开(公告)号：US08435962B2

公开(公告)日：2013-05-07

申请号：US13255153

申请日：2009-03-10

申请人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

发明人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/20

CPC分类号： A61K31/7076 ,  C07H19/167

摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

摘要翻译： 本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。 特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。 使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。 本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。 所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。 用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。

公开(公告)号：US09023440B2

公开(公告)日：2015-05-05

申请号：US13703668

申请日：2012-09-07

申请人： Ang Xiao ,  Haibo Zhu ,  Sunghun Song ,  Wei Li ,  Zhiyong Liu

发明人： Ang Xiao ,  Haibo Zhu ,  Sunghun Song ,  Wei Li ,  Zhiyong Liu

IPC分类号： C09K19/00 ,  C09D179/08 ,  G02F1/1337

CPC分类号： C09D179/08 ,  G02F1/133723 ,  G02F1/133784 ,  Y10T428/10 ,  Y10T428/1005 ,  Y10T428/1023

摘要： The invention provides a liquid crystal alignment film, a method for preparing the same and a liquid crystal display device comprising the same. The alignment film comprises a polyimide obtained by reacting a compound as shown in Formula 2 or Formula 3 with an aromatic diamine as shown in Formula 1, wherein the R1, R2, R3, R4, R5, R6, R7, R1′, R2′, R3′, R4′, R5′, R6′, R7′, or R8′ is H, an alkyl, an aralkyl or a haloalkyl, and the Ar is an aryl. The liquid crystal alignment film has a tactic spatial configuration, decreases the π-π attractive interaction between the polyimide backbones, allows the directional and homogenous alignment of the liquid crystal molecules on the surface of the polyimide, and thereby increases the contrast of the liquid crystal display.

摘要翻译： 本发明提供一种液晶取向膜，其制备方法和包含该液晶取向膜的液晶显示装置。 取向膜包括通过如式2或式3所示的化合物与式1所示的芳族二胺反应得到的聚酰亚胺，其中R1，R2，R3，R4，R5，R6，R7，R1'，R2' ，R 3'，R 4'，R 5'，R 6'，R 7'或R 8'为H，烷基，芳烷基或卤代烷基，Ar为芳基。 液晶取向膜具有策略空间结构，减少了＆pgr。 聚酰亚胺骨架之间的有吸引力的相互作用允许液晶分子在聚酰亚胺表面上的定向和均匀取向，从而增加了液晶显示器的对比度。

公开(公告)号：US20120053143A1

公开(公告)日：2012-03-01

申请号：US13255153

申请日：2009-03-10

申请人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

发明人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

IPC分类号： A61K31/7076 ,  C07H1/00 ,  A61P3/06 ,  C07H19/167

CPC分类号： A61K31/7076 ,  C07H19/167

摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

摘要翻译： 本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。 特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。 使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。 本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。 所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。 用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。