公开(公告)号：US08435962B2

公开(公告)日：2013-05-07

申请号：US13255153

申请日：2009-03-10

申请人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

发明人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/20

CPC分类号： A61K31/7076 ,  C07H19/167

摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

摘要翻译： 本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。 特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。 使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。 本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。 所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。 用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。

公开(公告)号：US20120053143A1

公开(公告)日：2012-03-01

申请号：US13255153

申请日：2009-03-10

申请人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

发明人： Haibo Zhu ,  Song Wu ,  Linghua Hao ,  Kai Qu ,  Ping Zhu ,  Xing Wang ,  Wei Li

IPC分类号： A61K31/7076 ,  C07H1/00 ,  A61P3/06 ,  C07H19/167

CPC分类号： A61K31/7076 ,  C07H19/167

摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

摘要翻译： 本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。 特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。 使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。 本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。 所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。 用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。

公开(公告)号：US08293718B2

公开(公告)日：2012-10-23

申请号：US12970268

申请日：2010-12-16

申请人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/11

CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2320/31 ,  C12N2320/51 ,  C12N2320/53 ,  Y02A50/467 ,  C12N2310/3521

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

摘要翻译： 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。

公开(公告)号：US20050249293A1

公开(公告)日：2005-11-10

申请号：US10959333

申请日：2004-10-05

申请人： Weimin Zeng ,  Li Alpha ,  Ping Zhu

发明人： Weimin Zeng ,  Li Alpha ,  Ping Zhu

IPC分类号： H04N5/21 ,  H04N7/26 ,  H04N5/217

CPC分类号： H04N5/21 ,  H04N19/117 ,  H04N19/14

摘要： A noise filter for a video processing system includes a block selector, a cost calculator, a cost table, a cost comparator, and a coefficient filter. The block selector is coupled to receive data from the quantization unit and selects blocks for additional filtering. The selected blocks are provided to the cost calculator determines a cost for each of the coefficients in the block using the cost table and the costs are summed. The cost comparator compares the total to a threshold, and filters the coefficients using the coefficient filter if the total is greater a preset threshold. The noise filter to the VLC unit then outputs the filter data.

摘要翻译： 用于视频处理系统的噪声滤波器包括块选择器，成本计算器，成本表，成本比较器和系数滤波器。 块选择器被耦合以从量化单元接收数据并且选择用于额外滤波的块。 所选择的块被提供给成本计算器使用成本表确定块中的每个系数的成本，并且将成本相加。 成本比较器将总和比较为阈值，并且如果总数大于预设阈值，则使用系数滤波器对系数进行滤波。 然后，VLC单元的噪声滤波器输出滤波器数据。

公开(公告)号：US20050249292A1

公开(公告)日：2005-11-10

申请号：US11065637

申请日：2005-02-23

申请人： Ping Zhu

发明人： Ping Zhu

IPC分类号： H04N7/12

CPC分类号： H04N19/1887 ,  H04N19/436 ,  H04N19/61 ,  H04N19/91 ,  H04N19/93

摘要： Video data compression requires several calculations to be made repeatedly on pixel data from the video. Some of those calculations are used to determine which way to encode portions of the video data, either to provide the best compression results or simply to comply with the MPEG specification. The present invention presents a set of calculations and logic that can be performed in parallel so that the delay is minimized in order to speed up the compression of digital video data. The present invention provides a third escape mode for use when in performing variable length coding.

摘要翻译： 视频数据压缩需要对来自视频的像素数据重复进行多次计算。 其中一些计算用于确定编码视频数据部分的方式，以提供最佳压缩结果或简单地符合MPEG规范。 本发明提出了可以并行执行的一组计算和逻辑，使得延迟最小化以便加速数字视频数据的压缩。 本发明提供了在执行可变长度编码时使用的第三逃逸模式。

公开(公告)号：US09009710B2

公开(公告)日：2015-04-14

申请号：US13258312

申请日：2010-05-25

申请人： Xingfeng Xie ,  Sujian Liu ,  Hua Chen ,  Ping Zhu

发明人： Xingfeng Xie ,  Sujian Liu ,  Hua Chen ,  Ping Zhu

IPC分类号： G06F11/00 ,  G06F11/07 ,  G06F11/30 ,  H04L12/26 ,  H04L29/08 ,  H04L29/14 ,  H04L29/06

CPC分类号： H04L67/06 ,  G06F11/07 ,  H04L43/00 ,  H04L43/08 ,  H04L43/0811 ,  H04L65/1066 ,  H04L67/00 ,  H04L69/40

摘要： A method and a device for file transfer protocol (FTP) deadlock detection and self recovery are provided by the disclosure in order to solve the sudden deadlock problem in the FTP upload task. The method includes: if a daemon determines that a deadlock occurs in an FTP upload task by a heartbeat detection mechanism, the socket resources used by the FTP upload task is recorded at the storage location in a socket resource cycle queue, and a process of ending the FTP upload task is started; determining whether the socket resource cycle queue is full, if it is not full, the socket resources used by the FTP upload task in the current deadlock is put into the socket resource cycle queue, otherwise, the earliest socket resources in the socket resource cycle queue are released, and the socket resources used by the FTP upload task in the current deadlock is put into the socket resource cycle queue.

摘要翻译： 本文提供了一种文件传输协议（FTP）死锁检测和自恢复的方法和装置，以解决FTP上传任务中突然的死锁问题。 该方法包括：如果守护程序通过心跳检测机制确定FTP上传任务中发生死锁，则FTP上传任务使用的套接字资源将记录在套接字资源周期队列中的存储位置，并且结束 FTP上传任务启动; 确定套接字资源周期队列是否满，如果未满，则将FTP当前死锁中的FTP上传任务使用的套接字资源放入套接字资源周期队列中，否则，套接字资源周期队列中的最早套接字资源 被释放，并且当前死锁中的FTP上传任务使用的套接字资源被放入套接字资源周期队列中。

公开(公告)号：US20110119830A1

公开(公告)日：2011-05-26

申请号：US12953156

申请日：2010-11-23

申请人： Hong Shang ,  Ning Tao Yang ,  Xiang Zhang ,  Ping Zhu

发明人： Hong Shang ,  Ning Tao Yang ,  Xiang Zhang ,  Ping Zhu

IPC分类号： A61G13/00

CPC分类号： A61B5/0555 ,  A61B6/0407 ,  G01R33/288

摘要： A gap protection device for an examining table includes a guide rail, a protecting chain and a rigid rope. The guide rail is fixed onto the non-moving part of the examining table. One end of the protecting chain is fixed onto the body of the examining table and is movable along the guide rail so as to cover the gap between the body and the non-moving part of the examining table. The two ends of the rigid rope are respectively connected to the two ends of the protecting chain. When the examining table is moved, the closed loop formed by the protecting chain and the rigid rope circulates synchronously under the drive of the examining table, such that the protecting chain covers the gap between the body and the non-moving part of the examining table.

摘要翻译： 用于检查台的间隙保护装置包括导轨，保护链和刚性绳索。 导轨固定在检查台的不动部分上。 保护链的一端固定在检查台的主体上，并可沿导轨移动，以覆盖主体与检查台的不动部分之间的间隙。 刚性绳索的两端分别连接到保护链的两端。 当检查台移动时，由保护链和刚性绳形成的闭环在检查台的驱动下同步地循环，使得保护链覆盖主体与检查台的不移动部分之间的间隙 。

公开(公告)号：US20100156601A1

公开(公告)日：2010-06-24

申请号：US12341607

申请日：2008-12-22

申请人： Lang LIN ,  Hugo Molina ,  Ping Zhu

发明人： Lang LIN ,  Hugo Molina ,  Ping Zhu

IPC分类号： H04Q5/22

CPC分类号： H04L67/12 ,  H04L67/28

摘要： A system includes a host computing device, a first RFID transceiver, and at least one second RFID transceiver. The host computing device executes an application according to a predetermined RFID communication protocol. The predetermined RFID communication protocol supports communication only with a single RFID transceiver. The first RFID transceiver communicates with the host computing device according to the predetermined RFID communication protocol. The at least one second RFID transceiver communicates with the first RFID transceiver. The at least one second RFID transceiver provides data to the host computing device only via the first RFID transceiver.

摘要翻译： 一种系统包括主计算设备，第一RFID收发器和至少一个第二RFID收发器。 主计算设备根据预定的RFID通信协议执行应用。 预定的RFID通信协议仅支持与单个RFID收发器的通信。 第一RFID收发器根据预定的RFID通信协议与主机计算设备进行通信。 所述至少一个第二RFID收发器与所述第一RFID收发器通信。 至少一个第二RFID收发器仅通过第一RFID收发器向主计算设备提供数据。

公开(公告)号：US20050228970A1

公开(公告)日：2005-10-13

申请号：US10209109

申请日：2002-07-30

申请人： Shuhua Xiang ,  Li Sha ,  Ping Zhu ,  Hongjun Yuan ,  Wei Ni

发明人： Shuhua Xiang ,  Li Sha ,  Ping Zhu ,  Hongjun Yuan ,  Wei Ni

IPC分类号： G06F7/57 ,  G06F9/38 ,  G06F15/00

CPC分类号： G06F9/3867 ,  G06F7/57 ,  G06F9/3824 ,  G06F9/3826 ,  G06F9/3885

摘要： A processing system includes an arithmetic logic unit (ALU) sub-system that allows data associated with a prior instruction to be preserved for use with a next instruction or subsequent instruction without having to reload the value using an intermediate register. The ALU sub-system includes a pair of ALUs communicatively cross-coupled with a pair of accumulators. The processing system also includes a data selector coupled to the ALU sub-system for use with memory contention prediction. The data selector includes a constant generator that controls storage of data associated with a previous instruction in a bypass element, and a selector to choose between data from a databus element and data stored in the bypass element.

摘要翻译： 处理系统包括算术逻辑单元（ALU）子系统，其允许与先前指令相关联的数据被保留以用于下一个指令或后续指令，而不必使用中间寄存器重新加载该值。 ALU子系统包括与一对蓄能器通信地交叉耦合的一对ALU。 处理系统还包括耦合到ALU子系统以与存储器争用预测一起使用的数据选择器。 数据选择器包括恒定发生器，其控制与旁路元件中的先前指令相关联的数据的存储，以及选择器，用于在数据总线元件的数据和存储在旁路元件中的数据之间进行选择。

公开(公告)号：US06379918B1

公开(公告)日：2002-04-30

申请号：US09374560

申请日：1999-08-13

申请人： Philip T. Feldsine ,  David E. Kerr ,  Ping Zhu ,  Linda Mui

发明人： Philip T. Feldsine ,  David E. Kerr ,  Ping Zhu ,  Linda Mui

IPC分类号： C12Q104

CPC分类号： G01N33/56922 ,  C12Q1/04 ,  C12Q1/045 ,  G01N33/56916 ,  G01N2333/205 ,  G01N2333/245 ,  G01N2333/255

摘要： Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or similar detection technology, wherein detection requires the discrimination among closely related genera, species and strains of antigenically related microorganisms based on immunological reactivity of a highly conserved antigen epitopes with a reagent system comprised of an antibody linked to a detecting reagent. The invention permits a detectable event to occur by exposing inaccessible but highly conserved and specific antigen epitopes to the detecting reagent. Exposure of such antigen epitopes without inactivating microbial metabolism allows for specific detection.