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1.发明申请公开(公告)号：US20120053143A1
公开(公告)日：2012-03-01
申请号：US13255153
申请日：2009-03-10
IPC分类号： A61K31/7076 , C07H1/00 , A61P3/06 , C07H19/167
CPC分类号： A61K31/7076 , C07H19/167
摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.
摘要翻译： 本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。 特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。 使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。 本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。 所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。 用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。
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2.发明授权公开(公告)号：US08435962B2
公开(公告)日：2013-05-07
申请号：US13255153
申请日：2009-03-10
CPC分类号： A61K31/7076 , C07H19/167
摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.
摘要翻译： 本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。 特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。 使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。 本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。 所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。 用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。
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公开(公告)号：US20180081192A1
公开(公告)日：2018-03-22
申请号：US15233504
申请日：2016-09-20
申请人： Kevin Kai Qu
发明人： Kevin Kai Qu
摘要： The present invention creates a new way of arranging harsh marks on a reticle that is to have the 2/10th and the 4/10th hash mark placed either above or below the horizontal base sighting line (See FIG. 2. Line 26) or on the left or right side of the vertical sighting base line (See FIG. 2. Line 27) at any unit of measurement of a segment and have the 6/10th and the 8/10th hash mark placed at the opposite side of the horizontal base sighting line (See FIG. 2. Line 26) and the vertical sighting lines (See FIG. 2. Line 27) compared with the 2/10th and the 4/10th marks.This new way of placing hash marks at every 2/10th of the unit of measurement allows a user to quickly identify and discern which numerical value a hash mark represents on the horizontal base sighting line and vertical sighting line without physically counting the numerical value of a hash mark in a linear way. The said hash marks are being referred to the vertical or horizontal dividing lines that divide a segment at any unit of measurement of a generally horizontal base sighting line or a generally vertical sighting line into equal fractional parts of the segment.
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