公开(公告)号：US08339599B2

公开(公告)日：2012-12-25

申请号：US12679614

申请日：2008-09-18

申请人： Oliver Reich ,  Hans-Gerd Löhmannsröben

发明人： Oliver Reich ,  Hans-Gerd Löhmannsröben

IPC分类号： G01J3/30

CPC分类号： G01J3/44 ,  A61B5/0059 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0297

摘要： The invention relates to a measuring arrangement for an optical spectrometer, in particular a photon density wave spectrometer, having a measuring chamber, which can be loaded with a sample to be measured, and a coupling-in/coupling-out device which is configured to receive excitation light from a light source and couple it into the sample to be measured in the measuring chamber and to receive measuring light formed in the sample to be measured on account of the excitation light which has been coupled in and to emit said measuring light to a detection device, wherein the coupling-in/coupling-out device has an optical switching device and a plurality of light guide elements which couple to the latter, have a respective optical waveguide and can be connected according to at least one selectable measuring configuration using the optical switching device in order to couple in the excitation light and receive the measuring light according to the at least one selectable measuring configuration, and wherein outputs of the plurality of light guide elements are positioned according to a spiral arrangement in the viewing direction of the outputs.

摘要翻译： 本发明涉及一种用于光谱仪，特别是光子密度波谱仪的测量装置，其具有可装载待测样品的测量室，以及耦合入/耦合输出装置，其被配置为 接收来自光源的激发光并将其耦合到测量室中要测量的样品中，并且由于已耦合并将所述测量光发射到所述测量光的激发光并接收待测样品中形成的测量光 一种检测装置，其中耦合输入/耦合输出装置具有光学开关装置和耦合到光开关装置的多个导光元件，其具有相应的光波导，并且可以根据至少一个可选择的测量配置连接，使用 所述光学开关装置为了耦合在所述激发光中并且根据所述至少一个可选择的测量配置接收所述测量光 并且其中多个导光元件的输出根据输出的观察方向上的螺旋排列而定位。

公开(公告)号：US20120094856A1

公开(公告)日：2012-04-19

申请号：US13143102

申请日：2010-01-22

申请人： Niko Hildebrandt ,  Daniel Geissler ,  Hans-Gerd Löhmannsröben ,  Emmanuel Bois ,  Loic Charbonniere ,  Raymond Ziessel

发明人： Niko Hildebrandt ,  Daniel Geissler ,  Hans-Gerd Löhmannsröben ,  Emmanuel Bois ,  Loic Charbonniere ,  Raymond Ziessel

IPC分类号： C40B30/04 ,  C40B40/00 ,  B82Y15/00

CPC分类号： G01N33/588 ,  B82Y15/00 ,  G01N33/542

摘要： The invention concerns a method for detecting an analyte in a sample by multiplexing FRET (Förster Resonance Energy Transfer) analysis, the method comprising the following steps: providing a sample containing an energy transfer donor, several spectrally different quantum dot species, and an analyte, wherein the analyte is configured to mediate an energy transfer within a first energy transfer donor-acceptor pair provided by the energy transfer donor and a first quantum dot specie, the energy transfer donor is configured to act as energy transfer donor in the first energy transfer donor-acceptor pair, and the first quantum dot specie is configured to act as energy transfer acceptor in the first energy transfer donor-acceptor pair, irradiating excitation light from an excitation light source to the sample, in the first energy transfer donor-acceptor pair, transferring excitation energy from the energy transfer donor excited by the excitation light to the first quantum dot specie, the energy transfer being mediated by the analyte, and detecting emission light emitted by the first quantum dot specie after receiving the excitation energy.

摘要翻译： 本发明涉及通过多路复用FRET（Förster共振能量转移）分析来检测样品中的分析物的方法，该方法包括以下步骤：提供含有能量转移供体，几个光谱不同的量子点物质和分析物的样品， 其中所述分析物被配置为介导由所述能量转移供体和第一量子点形式提供的第一能量转移供体 - 受体对内的能量转移，所述能量转移供体被配置为在所述第一能量转移供体 并且所述第一量子点形状被配置为在所述第一能量转移供体 - 受体对中作为所述第一能量转移供体 - 受体对中的能量转移受体，在激发光源中向所述样品照射激发光， 将由激发光激发的能量转移施主的激发能量转移到第一量子点物质， 能量转移由分析物介导，并且在接收到激发能量之后检测由第一量子点物质发射的发射光。