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    IMPLANTABLE LEAD WITH FLEXIBLE TIP FEATURES
    1.
    发明申请
    IMPLANTABLE LEAD WITH FLEXIBLE TIP FEATURES 有权
    具有灵活提示功能的可伸缩引线

    公开(公告)号：US20100042195A1

    公开(公告)日：2010-02-18

    申请号：US12508322

    申请日：2009-07-23

    申请人： Daniel J. Cooke ,  Leslie L. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, JR. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

    发明人： Daniel J. Cooke ,  Leslie L. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, JR. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

    IPC分类号： A61N1/05

    CPC分类号： A61N1/057 ,  A61N1/0568

    摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

    摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD
    2.
    发明申请
    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
    用于医疗铅和药物的药物涂覆涂料

    公开(公告)号：US20120052184A1

    公开(公告)日：2012-03-01

    申请号：US13288487

    申请日：2011-11-03

    申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    IPC分类号： B05D5/00 ,  B05D3/00 ,  B05D7/00

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

    摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并与位于引线主体上的至少一个电极相邻。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD
    3.
    发明申请
    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
    用于医疗铅和药物的药物涂覆涂料

    公开(公告)号：US20090054961A1

    公开(公告)日：2009-02-26

    申请号：US12234081

    申请日：2008-09-19

    申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

    摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并且邻近位于引线主体上的至少一个电极。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

    Implantable lead with flexible tip features
    6.
    发明授权
    Implantable lead with flexible tip features 有权
    可植入导线，具有灵活的尖端特征

    公开(公告)号：US08160721B2

    公开(公告)日：2012-04-17

    申请号：US12508322

    申请日：2009-07-23

    申请人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

    发明人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

    IPC分类号： A61N1/00

    CPC分类号： A61N1/057 ,  A61N1/0568

    摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

    摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

    Deionized water spray on loss of fluid processing tank exhaust
    7.
    发明授权
    Deionized water spray on loss of fluid processing tank exhaust 失效
    去离子水喷雾失去流体处理罐排气

    公开(公告)号：US06865937B2

    公开(公告)日：2005-03-15

    申请号：US10144684

    申请日：2002-05-13

    申请人： Alexander N Lerner ,  Harshad M Borgaonkar

    发明人： Alexander N Lerner ,  Harshad M Borgaonkar

    IPC分类号： B08B15/02 ,  G01F22/00

    CPC分类号： B08B15/02

    摘要： Methods and apparatus are provided for increasing the safety of a clogged or failed exhaust system. In accordance with a first embodiment, an apparatus is provided that includes (1) a tank adapted to contain a processing fluid; (2) an exhaust system coupled to the tank and adapted to exhaust a gas from the tank, the gas including a hazardous vapor of the processing fluid; (3) a sensor coupled to the exhaust system and adapted to detect a rate at which gas is exhausted from the tank; and (4) a fluid supply mechanism adapted to supply a diluting fluid to the tank so as to dilute the processing fluid contained by the tank if the rate at which gas is exhausted from the tank is less than a predetermined rate. Systems, methods and computer program products are provided in accordance with this and other embodiments.

    摘要翻译： 提供了提高堵塞或故障排气系统安全性的方法和装置。 根据第一实施例，提供了一种装置，其包括：（1）适于容纳处理流体的罐; （2）排气系统，其耦合到所述罐并且适于从所述罐排出气体，所述气体包括所述处理流体的危险蒸汽; （3）耦合到排气系统并适于检测气体从罐排出的速率的传感器; 以及（4）如果从罐中排出气体的速率小于预定速率，则适于向罐提供稀释流体以便稀释由罐所容纳的处理流体的流体供应机构。 根据本实施例和其他实施例提供了系统，方法和计算机程序产品。