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18 条记录 (耗时 0.035 秒)

    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD
    1.
    发明申请
    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
    用于医疗铅和药物的药物涂覆涂料

    公开(公告)号：US20120052184A1

    公开(公告)日：2012-03-01

    申请号：US13288487

    申请日：2011-11-03

    申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    IPC分类号： B05D5/00 ,  B05D3/00 ,  B05D7/00

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

    摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并与位于引线主体上的至少一个电极相邻。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD
    2.
    发明申请
    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
    用于医疗铅和药物的药物涂覆涂料

    公开(公告)号：US20090054961A1

    公开(公告)日：2009-02-26

    申请号：US12234081

    申请日：2008-09-19

    申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

    摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并且邻近位于引线主体上的至少一个电极。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

    Lead with fibrous matrix coating and methods related thereto
    5.
    发明授权
    Lead with fibrous matrix coating and methods related thereto 有权
    带有纤维基质涂层及其相关方法

    公开(公告)号：US07689291B2

    公开(公告)日：2010-03-30

    申请号：US11381018

    申请日：2006-05-01

    申请人： Jeannette C. Polkinghorne ,  Xiangchun Jiang ,  Daniel J. Cooke

    发明人： Jeannette C. Polkinghorne ,  Xiangchun Jiang ,  Daniel J. Cooke

    IPC分类号： A61N1/00

    CPC分类号： A61N1/056 ,  A61N1/0568 ,  A61N2001/0585 ,  D01D5/0084 ,  Y10S977/904 ,  Y10S977/931

    摘要： A lead includes a lead body extending from a lead proximal end portion to a lead distal end portion and having an intermediate portion therebetween, one or more tissue sensing/stimulation electrodes disposed along the lead body, one or more terminal connections disposed along the lead proximal end portion. The lead further includes one or more conductors contained within the lead body extending between the tissue sensing/stimulation electrodes and the terminal connections, and a fibrous matrix coating is disposed onto at least a portion of the lead body and/or sensing/stimulation electrodes.

    摘要翻译： 引线包括从引线近端部分延伸到引线远端部分并且在其间具有中间部分的引线体，沿着引线主体设置的一个或多个组织感测/刺激电极，沿着引线近端设置的一个或多个端子连接 端部。 引线还包括一个或多个导体，其包含在组织感测/刺激电极和端子连接之间延伸的引线体内，并且纤维基质涂层设置在引线体和/或感测/刺激电极的至少一部分上。

    Conductive polymer patterned electrode for pacing
    8.
    发明授权
    Conductive polymer patterned electrode for pacing 有权
    用于起搏的导电聚合物图案电极

    公开(公告)号：US08311606B2

    公开(公告)日：2012-11-13

    申请号：US11533644

    申请日：2006-09-20

    申请人： Xiangchun Jiang ,  Kevin J. Ely ,  Jeannette C. Polkinghorne

    发明人： Xiangchun Jiang ,  Kevin J. Ely ,  Jeannette C. Polkinghorne

    IPC分类号： A61B5/04

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： The present invention is an apparatus and method for making a polymer patterned electrode for cardiac pacing and sensing. The electrode surface includes a polymer overlayed on an electrode. The polymer layer is patterned to form an electrode surface consisting of a polymer and a conductive metal surface. The electrode can be made of a high or low impedance electrode by changing the conductivity of the polymer. Furthermore, the electrode surface texture can be optimized with a micro pattern that may enhance the biocompatibility. The polymer may be conductive or insulative.

    摘要翻译： 本发明是用于制造用于心脏起搏和感测的聚合物图案化电极的装置和方法。 电极表面包括覆盖在电极上的聚合物。 将聚合物层图案化以形成由聚合物和导电金属表面组成的电极表面。 通过改变聚合物的导电性，电极可以由高阻抗或低阻抗电极制成。 此外，电极表面纹理可以用可以增强生物相容性的微观图案来优化。 聚合物可以是导电的或绝缘的。

    METHOD AND APPARATUS FOR INTERCONNECTING ELECTRODES WITH PARTIAL TITANIUM COATING
    9.
    发明申请
    METHOD AND APPARATUS FOR INTERCONNECTING ELECTRODES WITH PARTIAL TITANIUM COATING 失效
    用于互连部分镀钛电极的方法和装置

    公开(公告)号：US20100155362A1

    公开(公告)日：2010-06-24

    申请号：US12716610

    申请日：2010-03-03

    申请人： James M. Poplett ,  Jeannette C. Polkinghorne ,  Gregory J. Sherwood

    发明人： James M. Poplett ,  Jeannette C. Polkinghorne ,  Gregory J. Sherwood

    IPC分类号： C23F1/00

    CPC分类号： H01G9/008 ,  H01G9/055 ,  H01G9/14 ,  Y10T29/417

    摘要： The present subject matter includes a capacitor stack having a plurality of anode layers, and a plurality of cathodic metal substrates partially coated in a titanium coating. Cathode portions lacking titanium enable weld interconnections which are substantially free of titanium, improving capacitor properties. In some embodiments, anodes are interspersed among cathodes, and are electrically separated from the cathodes, with portions of cathode material attached to the welding area of the anode. These portions of the cathode material are no longer electrically connected to the cathode. As the anode and these cathode portions are welded and aged, leakage current is reduced due to improved oxide growth in the welding area due to the absence of titanium.

    摘要翻译： 本主题包括具有多个阳极层的电容器堆叠和部分涂覆在钛涂层中的多个阴极金属衬底。 缺乏钛的阴极部分能够实现基本上不含钛的焊接互连，从而改善电容器性能。 在一些实施例中，阳极散布在阴极之间，并且与阴极电分离，阴极材料的部分附着到阳极的焊接区域。 阴极材料的这些部分不再与阴极电连接。 由于阳极和这些阴极部分被焊接和老化，由于不存在钛而导致焊接区域的氧化物生长增加，泄漏电流降低。

    FIBROUS ELECTRODE MATERIAL
    10.
    发明申请
    FIBROUS ELECTRODE MATERIAL 有权
    纤维电极材料

    公开(公告)号：US20110137389A1

    公开(公告)日：2011-06-09

    申请号：US13009655

    申请日：2011-01-19

    申请人： Jeannette C. Polkinghorne ,  Robert W. Warner ,  James Q. Feng ,  J. Lee Shippy, III ,  L. Liliana Atanasoska

    发明人： Jeannette C. Polkinghorne ,  Robert W. Warner ,  James Q. Feng ,  J. Lee Shippy, III ,  L. Liliana Atanasoska

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0565

    摘要： A biomimetic electrode material including a fibrous matrix including a conductive polymer and an ion conducting polymeric material is described. The biomimetic electrode material may be used in a number of body-implantable applications including cardiac and neuro-stimulation applications. The biomimetic electrode material can be formed using electrospinning and other related processes. The biomimetic electrode may facilitate efficient charge transport from ionically conductive tissue to the electronically conductive electrode, and may induce surrounding tissue to attach or interface directly to the implanted device, increasing the biocompatibility of the device.

    摘要翻译： 描述了包括包含导电聚合物和离子导电聚合材料的纤维基质的仿生电极材料。 仿生电极材料可用于许多可植入人体的应用，包括心脏和神经刺激应用。 仿生电极材料可以使用静电纺丝和其它相关工艺形成。 仿生电极可以促进从离子导电组织到电子导电电极的有效电荷输送，并且可以诱导周围组织附着或直接连接到植入装置，增加装置的生物相容性。