公开(公告)号：US08877222B2

公开(公告)日：2014-11-04

申请号：US13321215

申请日：2010-05-19

申请人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

发明人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

IPC分类号： A61F2/00 ,  A61K33/42 ,  A61K33/38 ,  A61K33/06 ,  A61L31/16 ,  A61L27/54 ,  A61L31/02 ,  A61L29/02 ,  A61L29/16 ,  A61L27/12

CPC分类号： A61L27/12 ,  A61L27/54 ,  A61L29/02 ,  A61L29/16 ,  A61L31/026 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/112 ,  A61L2300/404 ,  A61L2300/606

摘要： An object of the present invention is to provide an antibacterial medical equipment which has sufficient antibacterial activity in vivo and is excellent in compatibility with living tissues, and also can maintain antibacterial activity over a long period and has high safety.An antibacterial medical equipment characterized in that inositol phosphate is bonded to a Ca compound of a medical equipment whose surface is at least coated with a layer of the Ca compound, or a medical equipment comprising the Ca compound. The antibacterial medical equipment as described above, wherein silver ions are bonded to the inositol phosphate. A method for producing an antibacterial medical equipment, which comprises bringing a medical equipment whose surface is at least coated with a layer of a Ca compound, or a medical equipment comprising a Ca compound into contact with an aqueous solution of inositol phosphate to obtain an antibacterial medical equipment in which inositol phosphate is bonded to the Ca compound. The method for producing an antibacterial medical equipment, wherein inositol phosphate is bonded to the Ca compound and then the Ca compound is brought into contact with an aqueous solution containing silver ions to obtain an antibacterial medical equipment in which silver ions are bonded to the inositol phosphate.

摘要翻译： 本发明的目的在于提供一种在体内具有足够的抗菌活性并且与活组织相容性优异的抗菌医疗设备，并且能够长时间保持抗菌活性且安全性高。 一种抗菌医疗设备，其特征在于磷酸肌醇与其表面至少涂覆有Ca化合物层的医疗设备的Ca化合物或包含Ca化合物的医疗设备结合。 如上所述的抗菌医疗设备，其中银离子与磷酸肌醇结合。 一种抗菌医疗设备的制造方法，其特征在于，将表面至少涂覆有Ca化合物的医疗器械，或包含Ca化合物的医疗器械与磷酸肌醇水溶液接触，得到抗菌剂 磷酸肌醇与Ca化合物结合的医疗设备。 生产抗菌医疗设备的方法，其中将磷酸肌醇与Ca化合物接合，然后使Ca化合物与含有银离子的水溶液接触，得到银离子与磷酸肌醇结合的抗菌医疗设备 。

公开(公告)号：US20120064132A1

公开(公告)日：2012-03-15

申请号：US13321215

申请日：2010-05-19

申请人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

发明人： Mamoru Aizawa ,  Tomoyuki Hoshikawa ,  Ken Ishii ,  Haruki Funao

IPC分类号： A61K9/00 ,  A61P31/04 ,  C07F1/10 ,  A61K31/6615 ,  C07F9/117

CPC分类号： A61L27/12 ,  A61L27/54 ,  A61L29/02 ,  A61L29/16 ,  A61L31/026 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/112 ,  A61L2300/404 ,  A61L2300/606

摘要： An object of the present invention is to provide an antibacterial medical equipment which has sufficient antibacterial activity in vivo and is excellent in compatibility with living tissues, and also can maintain antibacterial activity over a long period and has high safety.An antibacterial medical equipment characterized in that inositol phosphate is bonded to a Ca compound of a medical equipment whose surface is at least coated with a layer of the Ca compound, or a medical equipment comprising the Ca compound. The antibacterial medical equipment as described above, wherein silver ions are bonded to the inositol phosphate. A method for producing an antibacterial medical equipment, which comprises bringing a medical equipment whose surface is at least coated with a layer of a Ca compound, or a medical equipment comprising a Ca compound into contact with an aqueous solution of inositol phosphate to obtain an antibacterial medical equipment in which inositol phosphate is bonded to the Ca compound. The method for producing an antibacterial medical equipment, wherein inositol phosphate is bonded to the Ca compound and then the Ca compound is brought into contact with an aqueous solution containing silver ions to obtain an antibacterial medical equipment in which silver ions are bonded to the inositol phosphate.

摘要翻译： 本发明的目的在于提供一种在体内具有足够的抗菌活性并且与活组织相容性优异的抗菌医疗设备，并且能够长时间保持抗菌活性且安全性高。 一种抗菌医疗设备，其特征在于磷酸肌醇与其表面至少涂覆有Ca化合物层的医疗设备的Ca化合物或包含Ca化合物的医疗设备结合。 如上所述的抗菌医疗设备，其中银离子与磷酸肌醇结合。 一种抗菌医疗设备的制造方法，其特征在于，将表面至少涂覆有Ca化合物的医疗器械，或包含Ca化合物的医疗器械与磷酸肌醇水溶液接触，得到抗菌剂 磷酸肌醇与Ca化合物结合的医疗设备。 生产抗菌医疗设备的方法，其中将磷酸肌醇与Ca化合物接合，然后使Ca化合物与含有银离子的水溶液接触，得到银离子与磷酸肌醇结合的抗菌医疗设备 。