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    Polyvalent multimeric composition containing active polypeptides, pharmaceutical compositions and methods of using the same
    4.
    发明申请
    Polyvalent multimeric composition containing active polypeptides, pharmaceutical compositions and methods of using the same 审中-公开
    含有活性多肽的多价多聚体组合物，药物组合物及其使用方法

    公开(公告)号：US20070053934A1

    公开(公告)日：2007-03-08

    申请号：US11510493

    申请日：2006-08-25

    申请人： Neville Kallenbach ,  Daniel Malamud ,  Zhigang Liu ,  William Abrams ,  Paramjit Arora

    发明人： Neville Kallenbach ,  Daniel Malamud ,  Zhigang Liu ,  William Abrams ,  Paramjit Arora

    IPC分类号： A61K31/70 ,  A61K39/12 ,  A01N43/04

    CPC分类号： C12N7/00 ,  A61K38/1709 ,  A61K47/58 ,  A61K47/595 ,  C07K14/47 ,  C07K14/4723 ,  C07K14/705 ,  C12N2740/16061

    摘要： The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents. The invention is also directed to the use of such complexes for delivery of anti-viral peptides, in particular, peptides and peptide fragments obtained from salivary agglutinin protein (gp-340) for use in treating or preventing infection with HIV.

    摘要翻译： 本发明涉及包含含有多个单体抗微生物肽的生物相容性聚合物骨架的多价复合物的组合物，以及使用这些复合物来稳定抗微生物肽以治疗或预防感染引起的疾病或病症的方法 用微生物。 已经研究了几种肽共价连接的现有抗微生物肽的多价衍生物。 所得构建体可以含有多达30个或更多个单元，并且相对于游离肽显示出显着增强的抗微生物效应：有效性提高十倍，这表明更高的多聚化确实会导致更有效的试剂 。 本发明还涉及这种复合物用于递送抗病毒肽，特别是从用于治疗或预防HIV感染的唾液凝集素蛋白（gp-340）获得的肽和肽片段的用途。

    Remote control drug delivery device
    7.
    发明授权
    Remote control drug delivery device 失效
    远程控制药物输送装置

    公开(公告)号：US5928195A

    公开(公告)日：1999-07-27

    申请号：US123299

    申请日：1998-07-28

    申请人： Daniel Malamud ,  Mitchell Litt ,  Benjamin L. Lewis

    发明人： Daniel Malamud ,  Mitchell Litt ,  Benjamin L. Lewis

    IPC分类号： A61M5/145 ,  A61M5/155

    CPC分类号： A61M5/14593

    摘要： A remotely controlled drug delivery device administers a dose of a drug, agent or microbicide using a gas pressure delivery system. The device stores multiple doses of the drug or agent. A toroid shaped housing includes three chambers, a gas chamber containing a pressurized gas, a drug storage chamber containing the drug or agent, and an expandable chamber for delivering the drug from the drug storage. The device includes an electronic controller for opening a valve connecting the gas chamber to the expandable chamber for a predetermined period of time in order to deliver a predetermined dose of the drug. The controller communicates with a remote control device via radio frequency. The remote control device sends a signal to the controller, which causes a dose to be delivered. The controller returns a signal to the remote control device indicating that the dose has been delivered and a signal indicating when the device needs to be removed for maintenance. The device may be used in any body cavity to deliver any desired type of drug.

    摘要翻译： 远程控制的药物递送装置使用气体压力输送系统施用一定剂量的药物，药剂或杀微生物剂。 该装置储存多剂量的药物或药剂。 环形壳体包括三个室，包含加压气体的气室，容纳药物或试剂的药物储存室，以及用于从药物储存器输送药物的可扩张室。 该装置包括电子控制器，用于打开将气体室连接到可膨胀腔室一段预定时间段的阀门，以便递送预定剂量的药物。 控制器通过无线电频率与遥控设备进行通信。 遥控装置向控制器发送一个信号，这导致一个剂量被传送。 控制器向远程控制装置返回一个信号，指示已经发送了剂量，并且指示何时需要将设备移除以进行维护的信号。 该装置可以用于任何体腔以递送任何所需类型的药物。