公开(公告)号：US08119774B2

公开(公告)日：2012-02-21

申请号：US10574885

申请日：2004-10-08

申请人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

发明人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

IPC分类号： C07K16/00 ,  C12N5/00

CPC分类号： C07K16/28 ,  A61K35/407 ,  C07K14/47 ,  C12N5/0672 ,  C12N2503/00 ,  G01N33/56966

摘要： The present invention provides a cell marker that is characterized by binding to a GCTM-5 antibody of active fragment. The cell marker identifies a unique sub-population of stem cells that show characteristics of hepatic or pancreatic stem cells or hepatic or pancreatic progenitor cells. More specifically the marker is an early liver marker, which could prove a useful tool for the isolation and identification of liver and pancreatic progenitors for both diseased adult liver and differentiating human embryonic stem cells.

摘要翻译： 本发明提供了特征在于结合活性片段的GCTM-5抗体的细胞标记物。 细胞标记鉴定出显示肝脏或胰腺干细胞或肝脏或胰腺祖细胞特征的干细胞的独特亚群。 更具体地说，标记物是早期肝脏标记物，其可以证明用于分离和鉴定患病成人肝脏和分化的人类胚胎干细胞的肝脏和胰腺祖细胞的有用工具。

公开(公告)号：US20070218059A1

公开(公告)日：2007-09-20

申请号：US10574885

申请日：2004-10-08

申请人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

发明人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

IPC分类号： A61K39/395 ,  G01N33/53

CPC分类号： C07K16/28 ,  A61K35/407 ,  C07K14/47 ,  C12N5/0672 ,  C12N2503/00 ,  G01N33/56966

摘要： The present invention provides a cell marker that is characterized by binding to a GCTM-5 antibody of active fragment. The cell marker identifies a unique sub-population of stem cells that show characteristics of hepatic or pancreatic stem cells or hepatic or pancreatic progenitor cells. More specifically the marker is an early liver marker, which could prove a useful tool for the isolation and identification of liver and pancreatic progenitors for both diseased adult liver and differentiating human embryonic stem cells.

摘要翻译： 本发明提供了特征在于结合活性片段的GCTM-5抗体的细胞标记物。 细胞标记鉴定出显示肝脏或胰腺干细胞或肝脏或胰腺祖细胞特征的干细胞的独特亚群。 更具体地说，标记物是早期肝脏标记物，其可以证明用于分离和鉴定患病成人肝脏和分化的人类胚胎干细胞的肝脏和胰腺祖细胞的有用工具。