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1.发明授权Metabolically enhanced photoautotrophic ethanol producing host cells, method for producing the host cells, constructs for the transformation of the host cells, and method of producing ethanol using the host cells 失效代谢增强的光自养乙醇生产宿主细胞，产生宿主细胞的方法，宿主细胞转化的构建体和使用宿主细胞产生乙醇的方法公开(公告)号：US08404466B2
公开(公告)日：2013-03-26
申请号：US13372456
申请日：2012-02-13
申请人： Kerstin Baier , Ulf Duhring , Christine Oesterhelt , Karl Ziegler , Heike Enke
发明人： Kerstin Baier , Ulf Duhring , Christine Oesterhelt , Karl Ziegler , Heike Enke
CPC分类号： C12P7/065 , C12N9/0006 , C12N9/1029 , C12N9/1217 , C12N9/88 , Y02E50/17
摘要： One embodiment of the invention provides a metabolically enhanced photoautotrophic, ethanol producing host cell comprising: at least two first metabolic enhancements reducing the enzymatic activity or affinity of at least two endogenous host cell enzymes involved in acetate and lactate fermentation, the first metabolic enhancements resulting in an enhanced level of biosynthesis of acetaldehyde, pyruvate, acetyl-CoA or precursors thereof compared to the respective wild type host cell, at least one second metabolic enhancement different from the first metabolic enhancement comprising an overexpressed enzyme for the formation of ethanol.
摘要翻译： 本发明的一个实施方案提供了代谢增强的光自养营养型乙醇生产宿主细胞，其包含：至少两种降低与参与乙酸盐和乳酸发酵的至少两种内源性宿主细胞酶的酶活性或亲和力的第一代谢增强，所述第一代谢增强导致 与相应的野生型宿主细胞相比，乙醛，丙酮酸，乙酰辅酶A或其前体的生物合成的增加水平与第一代谢增强不同的至少一种第二代谢增强包含用于形成乙醇的过表达酶。
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2.发明申请Metabolically Enhanced Photoautotrophic Ethanol Producing Host Cells, Method For Producing The Host Cells, Constructs For The Transformation Of The Host Cells, And Method Of Producing Ethanol Using The Host Cells 失效代谢增强的自营养型乙醇生产宿主细胞，产生宿主细胞的方法，用于宿主细胞转化的构建体和使用宿主细胞产生乙醇的方法公开(公告)号：US20120142066A1
公开(公告)日：2012-06-07
申请号：US13372456
申请日：2012-02-13
申请人： Kerstin BAIER , Ulf DUHRING , Christine OESTERHELT , Karl ZIEGLER , Heike ENKE
发明人： Kerstin BAIER , Ulf DUHRING , Christine OESTERHELT , Karl ZIEGLER , Heike ENKE
CPC分类号： C12P7/065 , C12N9/0006 , C12N9/1029 , C12N9/1217 , C12N9/88 , Y02E50/17
摘要： One embodiment of the invention provides a metabolically enhanced photoautotrophic, ethanol producing host cell comprising: at least two first metabolic enhancements reducing the enzymatic activity or affinity of at least two endogenous host cell enzymes involved in acetate and lactate fermentation, the first metabolic enhancements resulting in an enhanced level of biosynthesis of acetaldehyde, pyruvate, acetyl-CoA or precursors thereof compared to the respective wild type host cell, at least one second metabolic enhancement different from the first metabolic enhancement comprising an overexpressed enzyme for the formation of ethanol.
摘要翻译： 本发明的一个实施方案提供了代谢增强的光自养营养型乙醇生产宿主细胞，其包含：至少两种降低与参与乙酸盐和乳酸发酵的至少两种内源性宿主细胞酶的酶活性或亲和力的第一代谢增强，所述第一代谢增强导致 与相应的野生型宿主细胞相比，乙醛，丙酮酸，乙酰辅酶A或其前体的生物合成的增加水平与第一代谢增强不同的至少一种第二代谢增强包含用于形成乙醇的过表达酶。
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公开(公告)号：US09650642B2
公开(公告)日：2017-05-16
申请号：US12368060
申请日：2009-02-09
申请人： R. Paul Woods , Craig R. Smith , Dan Kramer , Heike Enke , Ulf Duhring , Kerstin Baier , Marianne Grundel , Wolfgang Lockau , Karl Ziegler , Christine Oesterhelt , John Coleman
发明人： R. Paul Woods , Craig R. Smith , Dan Kramer , Heike Enke , Ulf Duhring , Kerstin Baier , Marianne Grundel , Wolfgang Lockau , Karl Ziegler , Christine Oesterhelt , John Coleman
CPC分类号： C12N15/8243 , C12N15/74 , C12P7/065 , Y02E50/17
摘要： The invention provides novel compositions of matter for the production of ethanol from carbon dioxide and water. Particularly, the invention provides photoautotrophic organisms having a first and second genetic modification, wherein the first genetic modification improves the ethanol production from organisms having the second genetic modification.
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公开(公告)号：US20100068776A1
公开(公告)日：2010-03-18
申请号：US12368060
申请日：2009-02-09
申请人： R. Paul Woods , Craig R. Smith , Dan Kramer , Heike Enke , Kerstin Baier , Ulf Duhring , Karl Ziegler , Wolfgang Lockau , Marianne Grundel , John Coleman , Christine Oesterhelt
发明人： R. Paul Woods , Craig R. Smith , Dan Kramer , Heike Enke , Kerstin Baier , Ulf Duhring , Karl Ziegler , Wolfgang Lockau , Marianne Grundel , John Coleman , Christine Oesterhelt
CPC分类号： C12N15/8243 , C12N15/74 , C12P7/065 , Y02E50/17
摘要： The invention provides novel compositions of matter for the production of ethanol from carbon dioxide and water. Particularly, the invention provides photoautotrophic organisms having a first and second genetic modification, wherein the first genetic modification improves the ethanol production from organisms having the second genetic modification.
摘要翻译： 本发明提供了用于从二氧化碳和水生产乙醇的新型物质组合物。 特别地，本发明提供了具有第一和第二遗传修饰的光自养生物，其中第一遗传修饰改进了具有第二遗传修饰的生物体的乙醇产生。
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5.发明申请Genetically Modified Photoautotrophic Ethanol Producing Host Cells, Method For Producing The Host Cells, Constructs For The Transformation Of The Host Cells, Method For Testing A Photoautotrophic Strain For A Desired Growth Property And Method Of Producing Ethanol Using The Host Cells 审中-公开用于产生宿主细胞的遗传修饰的自营养型乙醇，用于产生宿主细胞的方法，用于宿主细胞转化的构建体，用于测试所需生长性质的自养营养型的方法和使用宿主细胞产生乙醇的方法公开(公告)号：US20100297736A1
公开(公告)日：2010-11-25
申请号：US12851712
申请日：2010-08-06
申请人： ULF DUHRING , HEIKE ENKE , DAN KRAMER , CRAIG R. SMITH , R. PAUL WOODS , KERSTIN BAIER , CHRISTINE OESTERHELT
发明人： ULF DUHRING , HEIKE ENKE , DAN KRAMER , CRAIG R. SMITH , R. PAUL WOODS , KERSTIN BAIER , CHRISTINE OESTERHELT
CPC分类号： C12N15/8243 , C12N15/74 , C12P7/065 , Y02E50/17
摘要： The invention provides genetically modified photoautotrophic ethanol producing host cells. Ethanol production is controlled by an inducible promoter. Promoters utilized may be endogenous or heterologous, and genetic modification may be obtained by extrachromosomal means or chromosomal insertion.
摘要翻译： 本发明提供了遗传修饰的光自养乙醇生产宿主细胞。 乙醇生产由诱导型启动子控制。 使用的启动子可以是内源的或异源的，并且可以通过染色体外的手段或染色体插入获得遗传修饰。
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