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Patent Agency Ranking
公开(公告)号：US20120316071A1
公开(公告)日：2012-12-13
申请号：US13508353
申请日：2010-11-04
Applicant: Vaughn Smider , Helen Hongyuan Mao
Inventor： Vaughn Smider , Helen Hongyuan Mao
CPC classification number: G01N33/6845 , C07K16/00 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C12N15/1058 , C40B30/04
Abstract: Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen.
Abstract translation: 本文提供了一种合成亲和力成熟方法，以基于抗体的结构/亲和力或活性关系演变抗体或其部分的活性。 所得的亲和力成熟抗体表现出针对靶抗原的改善或优化的结合亲和力。
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公开(公告)号：US20120058906A1
公开(公告)日：2012-03-08
申请号：US13128219
申请日：2009-11-04
Applicant: Vaughn Smider , James Graziano , Helen Hongyuan Mao , Byeong Doo Song , Tyson Case , Omar Bazirgan
Inventor： Vaughn Smider , James Graziano , Helen Hongyuan Mao , Byeong Doo Song , Tyson Case , Omar Bazirgan
CPC classification number: C07K16/22 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/2869 , C07K16/2884 , C07K16/2887 , C07K16/32 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C12N15/1037 , C40B40/08 , C40B50/08 , G01N33/6845
Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
Abstract translation: 提供了从人种系分段制备组合抗体文库的方法。 还提供了从编码VL链的种系节段编码的核酸分子的文库，以及编码VH链的核酸分子的文库以及所得的抗体文库。 这些库作为可寻址库提供。 提供了针对靶蛋白抗原筛选抗体文库的方法，以及鉴定或选择的抗体。
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公开(公告)号：US09403904B2
公开(公告)日：2016-08-02
申请号：US13128236
申请日：2009-11-04
Applicant: Vaughn Smider , Helen Hongyuan Mao , Cornelia Bentley , Tyson Chase
Inventor： Vaughn Smider , Helen Hongyuan Mao , Cornelia Bentley , Tyson Chase
CPC classification number: C07K16/22 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/2869 , C07K16/2884 , C07K16/2887 , C07K16/32 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C12N15/1037 , C40B40/08 , C40B50/08 , G01N33/6845
Abstract: Provided herein are anti-DLL4 antibodies and methods of using anti-DLL4 antibodies as therapeutic agents in diseases or disorders associated with DLL4.
Abstract translation: 本文提供了抗DLL4抗体和使用抗DLL4抗体作为与DLL4相关的疾病或病症中的治疗剂的方法。
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公开(公告)号：US09221902B2
公开(公告)日：2015-12-29
申请号：US13128219
申请日：2009-11-04
Applicant: Vaughn Smider , James Graziano , Helen Hongyuan Mao , Byeong Doo Song , Tyson Chase , Omar Bazirgan
Inventor： Vaughn Smider , James Graziano , Helen Hongyuan Mao , Byeong Doo Song , Tyson Chase , Omar Bazirgan
CPC classification number: C07K16/22 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/2869 , C07K16/2884 , C07K16/2887 , C07K16/32 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C12N15/1037 , C40B40/08 , C40B50/08 , G01N33/6845
Abstract: Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.
Abstract translation: 提供了从人种系分段制备组合抗体文库的方法。 还提供了从编码VL链的种系节段编码的核酸分子的文库，以及编码VH链的核酸分子的文库以及所得的抗体文库。 这些库作为可寻址库提供。 提供了针对靶蛋白抗原筛选抗体文库的方法，以及鉴定或选择的抗体。
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公开(公告)号：US20110318339A1
公开(公告)日：2011-12-29
申请号：US13128236
申请日：2009-11-04
Applicant: Vaughn Smider , Helen Hongyuan Mao , Cornelia Bentley , Tyson Chase
Inventor： Vaughn Smider , Helen Hongyuan Mao , Cornelia Bentley , Tyson Chase
IPC: A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , C12N1/21 , A61P19/02 , C12N1/19 , C12N1/00 , C12P21/02 , A61P35/00 , A61P9/10 , C07K16/18 , C12N1/15
CPC classification number: C07K16/22 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/2869 , C07K16/2884 , C07K16/2887 , C07K16/32 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C12N15/1037 , C40B40/08 , C40B50/08 , G01N33/6845
Abstract: Provided herein are anti-DLL4 antibodies and methods of using anti-DLL4 antibodies as therapeutic agents in diseases or disorders associated with DLL4.
Abstract translation: 本文提供了抗DLL4抗体和使用抗DLL4抗体作为与DLL4相关的疾病或病症中的治疗剂的方法。
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