公开(公告)号：US09119834B2

公开(公告)日：2015-09-01

申请号：US14005380

申请日：2012-03-16

申请人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

发明人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

IPC分类号： A61K39/235 ,  C12N7/02 ,  C12N15/861 ,  A61K39/00

CPC分类号： A61K39/235 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10221 ,  C12N2710/10234 ,  C12N2710/10243

摘要： A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.

摘要翻译： 描述了能够达到至少3log 10的病毒滴度的高水平复制禽腺病毒（FAdV）分离物。 所述FAdV是家禽腺病毒血清型4的非致病菌株，鉴定为FAdV-4 ON1。 此外，本公开还提供了包含家禽腺病毒的病毒载体，其插入了编码所关注疾病的至少一个抗原部位的外源核苷酸序列，以及获得所述病毒载体的方法和包含 一样。

公开(公告)号：US20140010834A1

公开(公告)日：2014-01-09

申请号：US14005380

申请日：2012-03-16

申请人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

发明人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

IPC分类号： A61K39/235

CPC分类号： A61K39/235 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10221 ,  C12N2710/10234 ,  C12N2710/10243

摘要： A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.

摘要翻译： 描述了能够达到至少3log 10的病毒滴度的高水平复制禽腺病毒（FAdV）分离物。 所述FAdV是家禽腺病毒血清型4的非致病菌株，鉴定为FAdV-4 ON1。 此外，本公开还提供了包含家禽腺病毒的病毒载体，其插入了编码所关注疾病的至少一个抗原部位的外源核苷酸序列，以及获得所述病毒载体的方法和包含 一样。