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1.发明授权Non-pathogenic serotype 4 fowl adenovirus (fadv-4) and viral vector thereof 有权非致病性血清型4家禽腺病毒（fadv-4）及其病毒载体公开(公告)号：US09119834B2
公开(公告)日：2015-09-01
申请号：US14005380
申请日：2012-03-16
申请人： Éva Nagy , Bryan Griffin , Helena Grgic , Davor Ojkic
发明人： Éva Nagy , Bryan Griffin , Helena Grgic , Davor Ojkic
IPC分类号： A61K39/235 , C12N7/02 , C12N15/861 , A61K39/00
CPC分类号： A61K39/235 , A61K39/12 , A61K2039/552 , C12N7/00 , C12N7/02 , C12N15/86 , C12N15/861 , C12N2710/10221 , C12N2710/10234 , C12N2710/10243
摘要： A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.
摘要翻译： 描述了能够达到至少3log 10的病毒滴度的高水平复制禽腺病毒（FAdV）分离物。 所述FAdV是家禽腺病毒血清型4的非致病菌株，鉴定为FAdV-4 ON1。 此外，本公开还提供了包含家禽腺病毒的病毒载体，其插入了编码所关注疾病的至少一个抗原部位的外源核苷酸序列，以及获得所述病毒载体的方法和包含 一样。
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公开(公告)号：US20110165224A1
公开(公告)日：2011-07-07
申请号：US12969444
申请日：2010-12-15
申请人： Susantha Gomis , Suresh Tikoo , Davor Ojkic
发明人： Susantha Gomis , Suresh Tikoo , Davor Ojkic
CPC分类号： A61K39/235 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , A61K2039/55561 , A61K2039/55566 , C12N7/00 , C12N2710/10034 , C12N2710/10234 , C12N2710/10251
摘要： A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.
摘要翻译： 一种包含分离的禽腺病毒（FAdV）的组合物，其中所述FAdV是选自FAdV-2，FAdV-7，FAdv-8a，FAdV-8b，FAdV-8a / 8b或FAdV-11血清型毒株的菌株; 以及在受试者和/或其后代中诱导保护性免疫的合适的载体和方法。
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3.发明申请NON-PATHOGENIC SEROTYPE 4 FOWL ADENOVIRUS (FADV-4) AND VIRAL VECTOR THEREOF 有权非致病性血清型4型腺病毒（FADV-4）及其病毒载体公开(公告)号：US20140010834A1
公开(公告)日：2014-01-09
申请号：US14005380
申请日：2012-03-16
申请人： Éva Nagy , Bryan Griffin , Helena Grgic , Davor Ojkic
发明人： Éva Nagy , Bryan Griffin , Helena Grgic , Davor Ojkic
IPC分类号： A61K39/235
CPC分类号： A61K39/235 , A61K39/12 , A61K2039/552 , C12N7/00 , C12N7/02 , C12N15/86 , C12N15/861 , C12N2710/10221 , C12N2710/10234 , C12N2710/10243
摘要： A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.
摘要翻译： 描述了能够达到至少3log 10的病毒滴度的高水平复制禽腺病毒（FAdV）分离物。 所述FAdV是家禽腺病毒血清型4的非致病菌株，鉴定为FAdV-4 ON1。 此外，本公开还提供了包含家禽腺病毒的病毒载体，其插入了编码所关注疾病的至少一个抗原部位的外源核苷酸序列，以及获得所述病毒载体的方法和包含 一样。
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公开(公告)号：US20130295126A1
公开(公告)日：2013-11-07
申请号：US13943990
申请日：2013-07-17
申请人： Susantha Gomis , Suresh Kumar Tikoo , Davor Ojkic
发明人： Susantha Gomis , Suresh Kumar Tikoo , Davor Ojkic
IPC分类号： A61K39/235
CPC分类号： A61K39/235 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , A61K2039/55561 , A61K2039/55566 , C12N7/00 , C12N2710/10034 , C12N2710/10234 , C12N2710/10251
摘要： A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.
摘要翻译： 一种包含分离的禽腺病毒（FAdV）的组合物，其中所述FAdV是选自FAdV-2，FAdV-7，FAdv-8a，FAdV-8b，FAdV-8a / 8b或FAdV-11血清型毒株的菌株; 以及在受试者和/或其后代中诱导保护性免疫的合适的载体和方法。
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公开(公告)号：US08524249B2
公开(公告)日：2013-09-03
申请号：US12969444
申请日：2010-12-15
申请人： Susantha Gomis , Suresh Kumar Tikoo , Davor Ojkic
发明人： Susantha Gomis , Suresh Kumar Tikoo , Davor Ojkic
IPC分类号： A61K39/295 , A61K39/235
CPC分类号： A61K39/235 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , A61K2039/55561 , A61K2039/55566 , C12N7/00 , C12N2710/10034 , C12N2710/10234 , C12N2710/10251
摘要： A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.
摘要翻译： 一种包含分离的禽腺病毒（FAdV）的组合物，其中所述FAdV是选自FAdV-2，FAdV-7，FAdv-8a，FAdV-8b，FAdV-8a / 8b或FAdV-11血清型毒株的菌株; 以及在受试者和/或其后代中诱导保护性免疫的合适的载体和方法。
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