公开(公告)号：US20140010834A1

公开(公告)日：2014-01-09

申请号：US14005380

申请日：2012-03-16

申请人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

发明人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

IPC分类号： A61K39/235

CPC分类号： A61K39/235 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10221 ,  C12N2710/10234 ,  C12N2710/10243

摘要： A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.

摘要翻译： 描述了能够达到至少3log 10的病毒滴度的高水平复制禽腺病毒（FAdV）分离物。 所述FAdV是家禽腺病毒血清型4的非致病菌株，鉴定为FAdV-4 ON1。 此外，本公开还提供了包含家禽腺病毒的病毒载体，其插入了编码所关注疾病的至少一个抗原部位的外源核苷酸序列，以及获得所述病毒载体的方法和包含 一样。

公开(公告)号：US20110145836A1

公开(公告)日：2011-06-16

申请号：US12636712

申请日：2009-12-12

申请人： Bradley WHEELER ,  Bryan GRIFFIN

发明人： Bradley WHEELER ,  Bryan GRIFFIN

IPC分类号： G06F13/00 ,  G06F9/46

CPC分类号： G06F9/542 ,  G06F9/546

摘要： A cloud computing monitoring system has an alert capturing system and a message transfer system that provides performance tracking and alert management to a local monitoring system. The alert capturing system may operate as part of a managed code framework and may capture and route alerts that may be transmitted to an operating system, as well as application exceptions and debugging information. A message queuing system may transmit the alerts to a local monitoring system, which may have a connector that subscribes to the cloud system's message queuing system.

摘要翻译： 云计算监控系统具有警报捕获系统和消息传输系统，其向本地监控系统提供性能跟踪和警报管理。 警报捕获系统可以作为托管代码框架的一部分来操作，并且可以捕获和路由可以传送到操作系统的警报，以及应用程序异常和调试信息。 消息队列系统可以将警报发送到本地监视系统，该系统可以具有订阅云系统的消息队列系统的连接器。

公开(公告)号：US20060000092A1

公开(公告)日：2006-01-05

申请号：US11125803

申请日：2005-05-10

申请人： Todd Ingalls ,  Kevin Wright ,  Bryan Griffin ,  Richard Brooks

发明人： Todd Ingalls ,  Kevin Wright ,  Bryan Griffin ,  Richard Brooks

IPC分类号： B21D53/10 ,  E03B9/02

CPC分类号： F16K1/422 ,  E03B9/04 ,  Y10T29/49409 ,  Y10T137/5327 ,  Y10T137/5392

摘要： A fire hydrant having a valve seat flange with an integral liner. In one embodiment, the fire hydrant includes a valve seat flange disposed between a standpipe and a hydrant shoe. The valve seat flange includes a standpipe neck defining internal threads to directly connect to the standpipe and a base flange to directly connect to the hydrant shoe. The liner includes an outer peripheral edge that is entrapped within the valve seat flange and an inner circumferential surface defining threads for receiving the valve seat of a valve assembly. The present invention also discloses a process of manufacturing a valve seat flange, including the steps of: (a) manufacturing the liner, (b) incorporating the liner into a core with the outer peripheral region of the liner exposed, (c) placing the integral core/liner into the valve seat flange mold and (d) forming the valve seat flange around the liner with the valve seat flange entrapping the outer peripheral region of the liner.

摘要翻译： 消防栓具有带一体式衬垫的阀座法兰。 在一个实施例中，消防栓包括设置在立管和消防栓鞋之间的阀座凸缘。 阀座法兰包括一个竖管颈，其定义内螺纹以直接连接到立管，以及一个底部法兰，以直接连接到消火栓鞋。 衬套包括被截留在阀座凸缘内的外周边缘和限定用于接纳阀组件的阀座的螺纹的内圆周表面。 本发明还公开了一种制造阀座凸缘的方法，包括以下步骤：（a）制造衬套，（b）将衬套结合到芯体中，其中衬垫的外围区域暴露，（c） 整体式的内芯/内衬到阀座法兰模具中，（d）围绕衬套形成阀座法兰，阀座法兰截留衬套的外围区域。

公开(公告)号：US09119834B2

公开(公告)日：2015-09-01

申请号：US14005380

申请日：2012-03-16

申请人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

发明人： Éva Nagy ,  Bryan Griffin ,  Helena Grgic ,  Davor Ojkic

IPC分类号： A61K39/235 ,  C12N7/02 ,  C12N15/861 ,  A61K39/00

CPC分类号： A61K39/235 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10221 ,  C12N2710/10234 ,  C12N2710/10243

摘要： A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.

摘要翻译： 描述了能够达到至少3log 10的病毒滴度的高水平复制禽腺病毒（FAdV）分离物。 所述FAdV是家禽腺病毒血清型4的非致病菌株，鉴定为FAdV-4 ON1。 此外，本公开还提供了包含家禽腺病毒的病毒载体，其插入了编码所关注疾病的至少一个抗原部位的外源核苷酸序列，以及获得所述病毒载体的方法和包含 一样。

公开(公告)号：US08819701B2

公开(公告)日：2014-08-26

申请号：US12636712

申请日：2009-12-12

申请人： Bradley Wheeler ,  Bryan Griffin

发明人： Bradley Wheeler ,  Bryan Griffin

IPC分类号： G06F3/00 ,  G06F9/44 ,  G06F9/46 ,  G06F13/00 ,  G06F9/54

CPC分类号： G06F9/542 ,  G06F9/546

摘要： A cloud computing monitoring system has an alert capturing system and a message transfer system that provides performance tracking and alert management to a local monitoring system. The alert capturing system may operate as part of a managed code framework and may capture and route alerts that may be transmitted to an operating system, as well as application exceptions and debugging information. A message queuing system may transmit the alerts to a local monitoring system, which may have a connector that subscribes to the cloud system's message queuing system.

摘要翻译： 云计算监控系统具有警报捕获系统和消息传输系统，其向本地监控系统提供性能跟踪和警报管理。 警报捕获系统可以作为托管代码框架的一部分来操作，并且可以捕获和路由可以传送到操作系统的警报，以及应用程序异常和调试信息。 消息队列系统可以将警报发送到本地监视系统，该系统可以具有订阅云系统的消息队列系统的连接器。