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公开(公告)号：US09109112B2
公开(公告)日：2015-08-18
申请号：US13703059
申请日：2011-06-27
Applicant: Ramabhadra Ratnagiri , Henry Keith Chenault
Inventor： Ramabhadra Ratnagiri , Henry Keith Chenault
CPC classification number: C08L71/02 , C08G2650/30 , C08L59/00 , Y10T428/1397 , C08L65/00 , C08L59/04
Abstract: Polyoxymethylene compositions with polyoxymethylene polymers polymer/polyol additives having a core-link-arm structure. Upon molding, these compositions exhibit stable melt viscosity and simultaneous improvement in notched Izod impact strength and/or decreased relative apparent capillary melt viscosity, and/or increased elongation at break, relative to polyoxymethylene compositions lacking such core-link-arm structure additives.
Abstract translation: 具有聚甲醛聚合物的聚甲醛组合物具有核心 - 连接臂结构的聚合物/多元醇添加剂。 在成型时，相对于缺乏这种核 - 链 - 臂结构添加剂的聚甲醛组合物，这些组合物显示出稳定的熔体粘度和同时改进的缺口伊佐德冲击强度和/或降低的相对表观毛细管熔融粘度和/或增加的断裂伸长率。
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公开(公告)号：US08680200B2
公开(公告)日：2014-03-25
申请号：US13258662
申请日：2010-03-26
Applicant: Henry Keith Chenault
Inventor： Henry Keith Chenault
IPC: C08G65/32 , C08G65/324 , C08G65/48
Abstract: Novel polyglycerol aldehyde polymers are described. The polymers comprise glycerol monomers connected by ether linkages and have 3 to about 170 aldehyde groups per molecule. The polyglycerol aldehydes may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.
Abstract translation: 描述了新的聚甘油醛聚合物。 聚合物包括通过醚键连接并且每分子具有3至约170个醛基的甘油单体。 聚甘油醛可以与各种含胺聚合物反应以形成水凝胶组织粘合剂和密封剂，其可用于医疗应用，例如伤口闭合，补充或替换内部手术操作如缝合吻合和血管吻合的组织或缝合物，组织 修复，防止液体如血液，胆汁，胃肠液和脑脊液的渗漏，眼科手术，药物递送和预防手术后粘连。
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3.发明授权公开(公告)号：US08426528B2
公开(公告)日：2013-04-23
申请号：US11064192
申请日：2005-02-23
Applicant: Mark Allen Andrews , Garret D. Figuly , Henry Keith Chenault
Inventor： Mark Allen Andrews , Garret D. Figuly , Henry Keith Chenault
IPC: C08L77/00 , C08G69/00 , C08F271/00
CPC classification number: C08B37/003 , C08G73/02 , C08G73/0206 , C08G73/028
Abstract: Processes for preparing crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels.
Abstract translation: 提供了使用生物质衍生的材料（如阿拉德糖和衍生物）制备交联聚合物的方法。 聚合物可以用作水凝胶。
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公开(公告)号：US08202963B2
公开(公告)日：2012-06-19
申请号：US13102262
申请日：2011-05-06
Applicant: Henry Keith Chenault , Garret D. Figuly
Inventor： Henry Keith Chenault , Garret D. Figuly
CPC classification number: C08G73/024 , C08L79/02
Abstract: An embodiment of the invention is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether amine with a bifunctional crosslinker of the formula: X1—R—X2. Another embodiment is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether having at least three arms and three electrophilic endgroups with a primary diamine crosslinker of the formula: NH2—R2—NH2, followed by treating of the chain-extended product so as to convert the remaining electrophilic endgroups to amine endgroups. Crosslinking of the chain-extended polyamine products with an oxidized polysaccharide provides useful tissue adhesives with modified elasticity, that provides greater compliance to underlying tissue, and improved stability in aqueous environments.
Abstract translation: 本发明的一个实施方案是通过包括使多臂聚醚胺与下式的双功能交联剂反应的方法制备的水溶性延伸链多胺产物：X1-R-X2。 另一个实施方案是通过包括使具有至少三个臂的多臂聚醚和三个亲电端基与下式的二胺交联剂：NH2-R2-NH2反应的方法制备的水溶性延伸链多胺产物， 链延长产物，以便将剩余的亲电端基转化为胺端基。 链延长的多胺产物与氧化多糖的交联提供了具有改进的弹性的有用的组织粘合剂，其提供对潜在组织的更大的依从性以及在水性环境中改善的稳定性。
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公开(公告)号：US20120014909A1
公开(公告)日：2012-01-19
申请号：US13258745
申请日：2010-03-26
Applicant: Henry Keith Chenault
Inventor： Henry Keith Chenault
CPC classification number: C09J171/02 , A61L24/0031 , A61L24/043 , A61L24/046 , C08G65/323 , C08G65/329 , C08G65/33306 , C08G2650/50 , C08L71/02 , C08L2203/02 , C08L2666/22
Abstract: A tissue adhesives and sealant formed by reacting a polyglycerol aldehyde with a water-dispersible, multi-arm amine is described. The tissue adhesive and sealant may be useful for medical and veterinary applications, including, but not limited to, wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions.
Abstract translation: 描述了通过使聚甘油醛与水分散性多臂胺反应形成的组织粘合剂和密封剂。 组织粘合剂和密封剂可用于医疗和兽医应用，包括但不限于在诸如肠内吻合和血管吻合的内部手术过程中的伤口闭合，补充或替换缝合线或缝钉，组织修复，防止流体渗漏 作为血液，胆汁，胃肠液和脑脊液，眼科手术，药物输送，并防止手术后粘连。
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Patent Agency Ranking
公开(公告)号：US07867738B2
公开(公告)日：2011-01-11
申请号：US12429509
申请日：2009-04-24
Applicant: Robert Dicosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
Inventor： Robert Dicosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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公开(公告)号：US20100240109A1
公开(公告)日：2010-09-23
申请号：US12429509
申请日：2009-04-24
Applicant: ROBERT DICOSIMO , Anna Panova , Henry Keith Chenault , Samuel David Arthur
Inventor： ROBERT DICOSIMO , Anna Panova , Henry Keith Chenault , Samuel David Arthur
IPC: C12P7/42
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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8.发明申请PROCESSES FOR PREPARING POLYMERS USING ALPHA,OMEGA-DIFUNCTIONAL ALDARAMIDES 审中-公开制备聚合物的方法，使用ALPHA，OMEGA-DIFUNCTIONAL ALDARAMIDES公开(公告)号：US20080146768A1
公开(公告)日：2008-06-19
申请号：US12014716
申请日：2008-01-15
Applicant: Mark Allen Andrews , Henry Keith Chenault , Garret D. Figuly
Inventor： Mark Allen Andrews , Henry Keith Chenault , Garret D. Figuly
CPC classification number: C08G69/02 , C07C231/02 , C08G69/08 , C08G69/10 , C08G69/26 , C07C235/08 , C07C235/10 , C07C235/12 , C07C235/16
Abstract: Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers are disclosed. The processes can be used to form polymers, particularly crosslinked polymers.
Abstract translation: 公开了使用α，ω-双官能的阿拉伯酰胺作为单体和交联剂的方法。 该方法可用于形成聚合物，特别是交联聚合物。
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公开(公告)号：US07351862B2
公开(公告)日：2008-04-01
申请号：US11360309
申请日：2006-02-23
Applicant: Mark Allen Andrews , Henry Keith Chenault , Garret D. Figuly
Inventor： Mark Allen Andrews , Henry Keith Chenault , Garret D. Figuly
IPC: C07C233/05
CPC classification number: C07C271/22 , C07C235/08 , C07C235/10 , C07C235/12 , C07C235/14
Abstract: Alpha, omega-difunctional aldaramides, in particular diaminoaldaramides, dihydroxyaldaramides, bis(alkoxycarbonylalkyl)aldaramides, and bis(carboxyalkyl)aldaramides, and processes for preparing the aldaramides are provided.
Abstract translation: α，ω-双官能的阿拉伯酰胺，特别是二氨基醛酰胺，二羟基芳酰胺，双（烷氧基羰基烷基）醛树脂和双（羧基烷基）醛树脂，以及制备醛缩酰胺的方法。
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公开(公告)号：US20130142978A1
公开(公告)日：2013-06-06
申请号：US13703059
申请日：2011-06-27
Applicant: Ramabhadra Ratnagiri , Henry Keith Chenault
Inventor： Ramabhadra Ratnagiri , Henry Keith Chenault
IPC: C08L71/02
CPC classification number: C08L71/02 , C08G2650/30 , C08L59/00 , Y10T428/1397 , C08L65/00 , C08L59/04
Abstract: Polyoxymethylene compositions with polyoxymethylene polymers polymer/polyol additives having a core-link-arm structure. Upon molding, these compositions exhibit stable melt viscosity and simultaneous improvement in notched Izod impact strength and/or decreased relative apparent capillary melt viscosity, and/or increased elongation at break, relative to polyoxymethylene compositions lacking such core-link-arm structure additives.
Abstract translation: 具有聚甲醛聚合物的聚甲醛组合物具有核心 - 连接臂结构的聚合物/多元醇添加剂。 在成型时，相对于缺乏这种核 - 链 - 臂结构添加剂的聚甲醛组合物，这些组合物显示出稳定的熔体粘度和同时改进的缺口伊佐德冲击强度和/或降低的相对表观毛细管熔融粘度和/或增加的断裂伸长率。
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