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公开(公告)号：US09175315B2
公开(公告)日：2015-11-03
申请号：US13162868
申请日：2011-06-17
申请人： Douglas Robert Anton , Stephane Francois Bazzana , Keith H Burlew , Jelena Cirakovic , Robert Dicosimo , Bruce A Diner , Michael Charles Grady , Brian Michael Roesch , Francis J Woerner
发明人： Douglas Robert Anton , Stephane Francois Bazzana , Keith H Burlew , Jelena Cirakovic , Robert Dicosimo , Bruce A Diner , Michael Charles Grady , Brian Michael Roesch , Francis J Woerner
IPC分类号： C12P7/62 , C12P7/22 , C12P7/16 , C12N1/00 , C12N1/12 , C07H21/04 , B01D3/00 , B01D21/26 , C07C29/86 , C11B1/02 , C11B13/00 , C12M1/00 , C12P7/64 , C12P7/18
CPC分类号： C12P7/16 , A23K10/38 , B01D3/002 , B01D11/0492 , B01D21/26 , B01D21/262 , C07C29/86 , C11B1/025 , C11B13/00 , C12F3/10 , C12M1/00 , C12M21/12 , C12M45/04 , C12M45/09 , C12N1/14 , C12N15/00 , C12P7/18 , C12P7/6418 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02W30/74
摘要： An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol esters. The alcohol esters can be extracted from the fermentation medium, and the product alcohol recovered from the alcohol esters. The carboxylic acid can also serve as an extractant for removal of the alcohol esters from the fermentation medium.
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公开(公告)号：US08652455B2
公开(公告)日：2014-02-18
申请号：US13330171
申请日：2011-12-19
申请人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
发明人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
CPC分类号： C12N9/18 , C07K16/16 , C07K19/00 , C07K2319/01 , C11D3/38636 , C11D3/38681 , C12N9/14 , C12N9/2437 , C12P7/40 , C12P7/54
摘要： Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
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公开(公告)号：US08445247B2
公开(公告)日：2013-05-21
申请号：US13547583
申请日：2012-07-12
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein are enzyme powders comprising a spray-dried formulation of at least one CE-7 esterase, at least one oligosaccharide excipient, and optionally at least one surfactant. Also disclosed herein is a process for producing peroxycarboxylic acids from carboxylic acid esters using the aforementioned enzyme powders. Further, disinfectant and laundry care formulations comprising the peracids produced by the processes described herein are provided.
摘要翻译： 本文公开了包含至少一种CE-7酯酶，至少一种寡糖赋形剂和任选的至少一种表面活性剂的喷雾干燥制剂的酶粉末。 本文还公开了使用上述酶粉末从羧酸酯制备过氧羧酸的方法。 此外，提供包含通过本文所述方法生产的过酸的消毒剂和衣物护理制剂。
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公开(公告)号：US08399234B2
公开(公告)日：2013-03-19
申请号：US13328364
申请日：2011-12-16
CPC分类号： C11D3/2093 , A61L2/186 , C11D3/38627 , C11D3/38636 , C11D3/3942 , C11D3/3947 , C12N9/18 , C12P7/40 , C12P7/54 , C12Y301/01
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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公开(公告)号：US08389260B2
公开(公告)日：2013-03-05
申请号：US13328418
申请日：2011-12-16
CPC分类号： C12N9/18 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritime acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
摘要翻译： 提供具有过水解活性的乙酰木聚糖酯酶变体，用于从羧酸酯和过氧源产生过氧羧酸。 更具体地，使用易错PCR和定点诱变来修饰Thermotoga海洋乙酰木聚糖酯酶基因，以产生特征在于比活性增加的酶催化剂。 变体乙酰木聚糖酯酶可用于制备适用于各种用途的过氧羧酸，例如清洁，消毒，消毒，漂白，木浆加工和纸浆加工应用。
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公开(公告)号：US08389258B2
公开(公告)日：2013-03-05
申请号：US13328336
申请日：2011-12-16
CPC分类号： C11D3/38636 , C11D3/3945 , C12N9/18 , C12P7/40 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
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公开(公告)号：US08389255B2
公开(公告)日：2013-03-05
申请号：US13070135
申请日：2011-03-23
IPC分类号： C12N9/18
CPC分类号： C12N9/18 , C11D3/38636 , C12P7/40 , C12P7/54
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
摘要翻译： 提供具有过水解活性的乙酰木聚糖酯酶变体，用于从羧酸酯和过氧源产生过氧羧酸。 更具体地，使用易错PCR和定点诱变来修饰热转录海马乙酰木聚糖酯酶基因，以产生特征在于比活性增加的酶催化剂。 变体乙酰木聚糖酯酶可用于制备适用于各种用途的过氧羧酸，例如清洁，消毒，消毒，漂白，木浆加工和纸浆加工应用。
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公开(公告)号：US20120317733A1
公开(公告)日：2012-12-20
申请号：US13330105
申请日：2011-12-19
申请人： Dexter A. Chisholm , Xiumin Cui , Scott D. Cunningham , Robert DiCosimo , Stephen R. Fahnestock , Tanja Maria Gruber , Yongqing Huang , Xueping Jiang , Anju Parthasarathy , Mark S. Payne , Pierre E. Rouviere , Hong Wang
发明人： Dexter A. Chisholm , Xiumin Cui , Scott D. Cunningham , Robert DiCosimo , Stephen R. Fahnestock , Tanja Maria Gruber , Yongqing Huang , Xueping Jiang , Anju Parthasarathy , Mark S. Payne , Pierre E. Rouviere , Hong Wang
CPC分类号： A61K8/66 , A61K8/22 , A61K8/38 , A61K8/64 , A61K38/46 , A61K38/465 , A61Q5/08 , A61Q5/10 , A61Q9/04 , A61Q15/00 , A61Q19/00 , A61Q19/02
摘要： Disclosed herein are compositions and methods to treat hair with a peracid-based benefit agent. The peracid benefit agent can be used for hair bleaching, hair weakening, hair removal, hair waiving, hair straightening or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a hair-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the hair surface.
摘要翻译： 本文公开了用基于过酸的有益试剂治疗毛发的组合物和方法。 过酸有益剂可用于头发漂白，头发削弱，脱毛，脱毛，头发矫直或其任何组合。 在过氧源的存在下，可以使用具有过水解活性的酶（过水解酶），由羧酸酯底物酶促产生过酸。 包含直接或通过任选的接头与毛发结合结构域偶联的过水解酶的融合蛋白可用于将头发表面的水解活性靶向。
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公开(公告)号：US20120156738A1
公开(公告)日：2012-06-21
申请号：US13162868
申请日：2011-06-17
申请人： Douglas Robert Anton , Stephane Francois Bazzana , Keith H. Burlew , Jelena Cirakovic , Robert Dicosimo , Bruce A. Diner , Michael Charles Grady , Brian Michael Roesch , Francis J. Woerner
发明人： Douglas Robert Anton , Stephane Francois Bazzana , Keith H. Burlew , Jelena Cirakovic , Robert Dicosimo , Bruce A. Diner , Michael Charles Grady , Brian Michael Roesch , Francis J. Woerner
CPC分类号： C12P7/16 , A23K10/38 , B01D3/002 , B01D11/0492 , B01D21/26 , B01D21/262 , C07C29/86 , C11B1/025 , C11B13/00 , C12F3/10 , C12M1/00 , C12M21/12 , C12M45/04 , C12M45/09 , C12N1/14 , C12N15/00 , C12P7/18 , C12P7/6418 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02W30/74
摘要： An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol esters. The alcohol esters can be extracted from the fermentation medium, and the product alcohol recovered from the alcohol esters. The carboxylic acid can also serve as an extractant for removal of the alcohol esters from the fermentation medium.
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公开(公告)号：US20120156162A1
公开(公告)日：2012-06-21
申请号：US13328418
申请日：2011-12-16
IPC分类号： A61L9/01 , C12N9/16 , C12N1/21 , D21H21/32 , A01N37/02 , C07H21/04 , D06L3/00 , C12P7/62 , C12N15/63
CPC分类号： C12N9/18 , C12Y301/01072
摘要： An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritime acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
摘要翻译： 提供具有过水解活性的乙酰木聚糖酯酶变体，用于从羧酸酯和过氧源产生过氧羧酸。 更具体地，使用易错PCR和定点诱变来修饰Thermotoga海洋乙酰木聚糖酯酶基因，以产生特征在于比活性增加的酶催化剂。 变体乙酰木聚糖酯酶可用于制备适用于各种用途的过氧羧酸，例如清洁，消毒，消毒，漂白，木浆加工和纸浆加工应用。
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