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    Method of detecting anti-Chlamydia pneumoniae antibody using Chlamydia pneumoniae-specific antigens
    2.
    发明授权
    Method of detecting anti-Chlamydia pneumoniae antibody using Chlamydia pneumoniae-specific antigens 失效
    使用肺炎衣原体特异性抗原检测肺炎衣原体抗体的方法

    公开(公告)号：US06489122B1

    公开(公告)日：2002-12-03

    申请号：US09689913

    申请日：2000-10-12

    申请人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    发明人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    IPC分类号： G01N3353

    CPC分类号： C12N9/003 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K2319/00

    摘要： Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1, DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; a method for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; reagents for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, which comprise the antigenic polypeptide as an antigen; agents for diagnosis of Chlamydia pneumoniae infections, which comprise the antigenic polypeptide as an active ingredient; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrotolate reductase, in which polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1 is bound to the polypeptide of SEQ ID NO: 14 either directly or via an intervening amino acid or amino acid sequence; DNAs encoding the fused proteins, or DNAs complementary thereto.

    摘要翻译： 包含在SEQ ID NO：1的多肽中含有至少5个连续氨基酸的序列的多肽A，编码抗原性多肽的DNA或与其互补的DNA的肺炎衣原体抗原多肽; 用于检测和/或测量肺炎衣原体抗体的方法，其中所述抗原多肽用作抗原; 用于检测和/或测量抗肺炎衣原体抗体的试剂，其包含抗原多肽作为抗原; 用于诊断肺炎衣原体感染的药剂，其包含抗原多肽作为活性成分; 衣原体肺炎衣原体的抗原性多肽与二氢醇酸酯还原酶的融合蛋白，其中包含SEQ ID NO：1的多肽中至少5个连续氨基酸的序列的多肽A直接或者直接或者与SEQ ID NO：14的多肽结合 通过插入的氨基酸或氨基酸序列; 编码融合蛋白的DNA或与其互补的DNA。

    Chlamydia pneumoniae antigenic polypeptide
    4.
    发明授权
    Chlamydia pneumoniae antigenic polypeptide 失效
    肺炎衣原体抗原多肽

    公开(公告)号：US06491924B1

    公开(公告)日：2002-12-10

    申请号：US09689916

    申请日：2000-10-12

    申请人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    发明人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    IPC分类号： A61K39118

    CPC分类号： C12N9/003 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K2319/00

    摘要： Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; a method for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, which comprise the antigenic polypeptide as an antigen; agents for diagnosis of Chlamydia pneumoniae infections, which comprise the antigenic polypeptide as an active ingredient; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrofolate reudctase; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the fused protein is used as an antigen; reagents for detection and/or measurement of an anti-Chlamydia pneumoniae antibody, which comprise the fused protein as an antigen; agents for diagnosis of Chlamydia pneumoniae infections, which comprise the fused protein as an active ingredient.

    摘要翻译： 肺炎链球菌抗原多肽，其包含在SEQ ID NO：1的多肽中含有至少5个连续氨基酸的序列的多肽A. 编码抗原多肽的DNA或与其互补的DNA; 抗肺炎衣原体抗体的生产方法，其中抗原多肽用作抗原; 用于检测和/或测量抗肺炎衣原体抗体的方法，其包含抗原多肽作为抗原; 用于诊断肺炎衣原体感染的药剂，其包含抗原多肽作为活性成分; 肺炎衣原体的抗原多肽与二氢叶酸reudctase的融合蛋白; 制备抗肺炎衣原体抗体的方法，其中所述融合蛋白用作抗原; 用于检测和/或测量抗肺炎衣原体抗体的试剂，其包含融合蛋白作为抗原; 用于诊断肺炎衣原体感染的药剂，其包含融合蛋白作为活性成分。

    Method of detecting chlamydia pneumoniae gene using polynucleotides
    5.
    发明授权
    Method of detecting chlamydia pneumoniae gene using polynucleotides 失效
    使用多核苷酸检测肺炎衣原体基因的方法

    公开(公告)号：US06485914B1

    公开(公告)日：2002-11-26

    申请号：US09689914

    申请日：2000-10-12

    申请人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    发明人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    IPC分类号： C12Q168

    CPC分类号： C12N9/003 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K2319/00

    摘要： Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; DNAs encoding the probes and primers for detection and/or measurement of Chlamydia pneumoniae gene. The present invention further provides a method for detection and/or measurement of Chlamydia pneumoniae gene, wherein the probe or primer is used; reagents for detection and/or measurement of Chlamydia pneumoniae gene, which comprise the probe or primer; and agents for diagnosis of Chlamydia pneumoniae infections, which comprise the probe or primer as an active ingredient.

    摘要翻译： 肺炎链球菌抗原多肽，其包含在SEQ ID NO：1的多肽中含有至少5个连续氨基酸的序列的多肽A. 编码抗原多肽的DNA或与其互补的DNA; 编码用于检测和/或测量肺炎衣原体基因的探针和引物的DNA。 本发明还提供一种检测和/或测量肺炎衣原体基因的方法，其中使用探针或引物; 用于检测和/或测量肺炎衣原体基因的试剂，其包含探针或引物; 以及用于诊断肺炎衣原体感染的药剂，其包含探针或底物作为活性成分。

    DNA encoding Chlamydia pneumoniae antigenic polypeptide
    6.
    发明授权
    DNA encoding Chlamydia pneumoniae antigenic polypeptide 失效
    编码肺炎衣原体抗原多肽的DNA

    公开(公告)号：US6165478A

    公开(公告)日：2000-12-26

    申请号：US809326

    申请日：1997-03-19

    申请人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    发明人： Hiroshi Izutsu ,  Kazuhiko Obara ,  Akira Matsumoto

    IPC分类号： C12N15/02 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/00 ,  C07K16/12 ,  C12N1/21 ,  C12N9/06 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/91 ,  G01N33/569 ,  A61K39/118

    CPC分类号： C12N9/003 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K2319/00

    摘要： Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding said antigenic polypeptides, or DNAs complementary thereto; recombinant vectors carrying said DNAs; transformants containing said recombinant vectors; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrofolate reductase, in which polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1 is bound to the polypeptide of SEQ ID NO: 14 either directly or via an intervening amino acid or amino acid sequence; DNAs encoding the fused proteins, or DNAs complementary thereto; recombinant vectors carrying the DNAs; transformants containing said recombinant vectors; a method for production of an anti-Chlamydia pneumoniae antibody; probes and primers for detection and/or measurement of Chlamydia pneumoniae gene; a method for detection and/or measurement of Chlamydia pneumoniae gene, wherein the probe or primer is used; reagents for detection and/or measurement of Chlamydia pneumoniae gene, which comprise the probe or primer; and agents for diagnosis of Chlamydia pneumoniae infections, which comprise the probe or primer as an active ingredient.

    摘要翻译： PCT No.PCT / JP95 / 01896 Sec。 371日期1997年3月19日 102（e）1997年3月19日PCT PCT 1995年9月20日PCT公布。 公开号WO96 / 09320 日期1996年3月28日肺炎衣原体抗原多肽，其包含在SEQ ID NO：1的多肽中含有至少5个连续氨基酸的序列的多肽A. 编码所述抗原多肽的DNA或与其互补的DNA; 携带所述DNA的重组载体; 含有所述重组载体的转化体; 抗肺炎衣原体抗体的生产方法，其中抗原多肽用作抗原; 肺炎衣原体的抗原性多肽与二氢叶酸还原酶的融合蛋白，其中包含SEQ ID NO：1的多肽中的至少5个连续氨基酸的序列的多肽A直接或者直接或者与SEQ ID NO：14的多肽结合 通过插入的氨基酸或氨基酸序列; 编码融合蛋白的DNA或与其互补的DNA; 载有DNA的重组载体; 含有所述重组载体的转化体; 生产抗肺炎衣原体抗体的方法; 用于检测和/或测量肺炎衣原体基因的探针和引物; 用于检测和/或测量肺炎衣原体基因的方法，其中使用所述探针或引物; 用于检测和/或测量肺炎衣原体基因的试剂，其包含探针或引物; 以及用于诊断肺炎衣原体感染的药剂，其包含探针或底物作为活性成分。

    Chlamydia pneumoniae antigens, method for production of the antigens, method and reagents for measurement of anti-Chlamydia pneumoniae antibodies using the antigens
    7.
    发明授权
    Chlamydia pneumoniae antigens, method for production of the antigens, method and reagents for measurement of anti-Chlamydia pneumoniae antibodies using the antigens 失效
    肺炎衣原体抗原，抗原产生方法，使用抗原测定抗肺炎衣原体抗体的方法和试剂

    公开(公告)号：US6146839A

    公开(公告)日：2000-11-14

    申请号：US930775

    申请日：1997-09-26

    申请人： Toshihide Morikawa ,  Kiyotaka Kawagoe ,  Hiroshi Izutsu ,  Akifumi Iguchi ,  Mitsuo Yamaki

    发明人： Toshihide Morikawa ,  Kiyotaka Kawagoe ,  Hiroshi Izutsu ,  Akifumi Iguchi ,  Mitsuo Yamaki

    IPC分类号： G01N33/569 ,  G01N33/571 ,  A61K35/14 ,  A61K39/118 ,  C12Q1/00

    CPC分类号： G01N33/56927

    摘要： The present invention relates to a Chlamydia pneumoniae antigen comprising protein derived from the outer membrane of Chlamydia pneumoniae, a method for producing a Chlamydia pneumoniae antigen which comprises solubilizing the cytosol and the cytoplasmic membrane of Chlamydia pneumoniae elementary body with an ionic detergent, and then removing the solubilized portion to obtain the residue, a method for measuring an anti-Chlamydia pneumoniae antibody which comprises using the Chlamydia pneumoniae antigen, and a reagent for measuring anti-Chlamydia pneumoniae antibody, said reagent comprising the Chlamydia pneumoniae antigen.In accordance with the present invention, there are provided a Chlamydia pneumoniae antigen which has a high species-specificity, very few clinically problematic false negatives, and few false positives, a method for producing said antigen, a method for measuring an anti-Chlamydia pneumoniae antibody, and a reagent for measuring an anti-Chlamydia pneumoniae antibody.

    摘要翻译： PCT No.PCT / JP96 / 00827 Sec。 371日期：1997年9月29日 102（e）1997年9月29日PCT PCT 1996年3月28日PCT公布。 WO96 / 30763 PCT出版物 日期：1996年10月3日本发明涉及包含肺炎衣原体外膜衍生物的肺炎衣原体抗原，本发明涉及肺炎衣原体抗原的制备方法，其特征在于，将肺炎衣原体的细胞溶质和胞质膜与离子性 洗涤剂，然后除去溶解部分以获得残留物，测定包含使用肺炎衣原体抗原的抗肺炎衣原体抗体的方法和用于测量抗肺炎衣原体抗体的试剂，所述试剂包含肺炎衣原体抗原。 根据本发明，提供了肺炎衣原体抗原，其具有高物种特异性，非常少的临床有问题的假阴性，少量假阳性，产生所述抗原的方法，测定抗肺炎衣原体的方法 抗体和用于测量抗肺炎衣原体抗体的试剂。